scholarly journals Effect of Vitamin C Supplementation on Blood Lead Level, Oxidative Stress and Antioxidant Status of Battery Manufacturing Workers of Western Maharashtra, India

2016 ◽  
Author(s):  
Ganesh Ghanwat
Keyword(s):  
Oxidative Stress ◽  
Vitamin C ◽  
Blood Lead Level ◽  
Antioxidant Status ◽  
Lead Level ◽  
Blood Lead ◽  
Vitamin C Supplementation

scholarly journals Activated Carbon Fabric Respiratory Mask reduces Blood Lead, Oxidative Stress and Improves the Antioxidant Status and Liver Functions in Unorganised Battery Workers

2020 ◽  
Vol 11 (4) ◽  
pp. 7247-7253
Author(s):  
Jyotsna A Patil ◽  
Mandakini S Kshirsagar ◽  
Arun J Patil
Keyword(s):  
Oxidative Stress ◽  
Superoxide Dismutase ◽  
Activated Carbon ◽  
Blood Lead Level ◽  
Antioxidant Status ◽  
Lead Level ◽  
Lipid Peroxide ◽  
Blood Lead ◽  
Carbon Fabric ◽  
Liver Functions

Effect of use of Activated Carbon Fabric (ACF) mask on blood lead (PbB), lipid peroxide, erythrocytes-Superoxide Dismutase (SOD), Catalase, Ceruloplasmin, and liver functions tests of battery manufacturing workers (BMW) were studied. For this study, 36 male battery manufacturing workers, those who are regularly using ACF mask for two months were included. A blood sample was collected before and after using ACF masks from battery manufacturing workers and estimated the blood lead level, liver function tests, oxidative stress, and antioxidant status parameters by using the standard method. After two months use of ACF mask by BMW, the blood lead level (P<0.01, -15.76%), total serum bilirubin (P<0.05, -28.09%), alanine transaminase (P<0.05, -20.84%), lipid peroxide (P<0.001, -33.33%) were significantly decreased and erythrocytes-superoxide dismutase (P<0.05, 22.38%), catalase (P<0.05, 38.39%), ceruloplasmin (P<0.05, 13.13%) were significantly increased in battery manufacturing workers as compared to before using the mask. This study reflects the use of two months ACF mask of high lead-exposed workers are useful to decrease lead absorption, which results in decreases oxidative stress and improves the antioxidant status and prevents liver toxicity.

scholarly journals Environmental Lead Exposure, Catalase Gene, and Markers of Antioxidant and Oxidative Stress Relation to Hypertension: An Analysis Based on the EGAT Study

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Jintana Sirivarasai ◽  
Sukhumpun Kaojarern ◽  
Suwannee Chanprasertyothin ◽  
Pachara Panpunuan ◽  
Krittaya Petchpoung ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lead Exposure ◽  
Blood Lead Level ◽  
Lead Level ◽  
Blood Lead ◽  
Cross Sectional Study ◽  
Oxidative Stress Marker ◽  
Blood Levels ◽  
Cross Sectional ◽  
Cat Gene

Lead has been linked to the development of hypertension via oxidative stress. Catalase plays an important role in the disposal of hydrogen peroxide in erythrocyte and its activity was determined by CAT gene. The aims of this study were to investigate (1) the association between blood levels of antioxidant markers such as catalase, superoxide dismutase, glutathione, glutathione peroxidase, oxidative stress-marker (malondialdehyde), and blood lead level and (2) the influence of genetic polymorphism of CAT gene (rs769217) on change in blood pressure in general population of EGAT study project. This is a cross-sectional study of 332 normotensive, 432 prehypertensive, and 222 hypertensive male subjects. Hypertensive subjects had significantly higher blood lead level (5.28 μg/dL) compared to normotensive (4.41 μg/dL) and prehypertensive (4.55 μg/dL) subjects (P<0.05). These significant findings are also found in MDA levels. Moreover, individuals with TT genotype in hypertensive group had significantly higher blood lead and MDA levels (6.06 μg/dL and 9.67 μmol/L) than those with CC genotype (5.32 μg/dL and 8.31 μmol/L,P<0.05). Our findings suggested that decreased blood catalase activity in this polymorphism together with low level lead exposure induced lipid peroxidation may be responsible for hypertension.

scholarly journals Oxidative Stress in Painters Exposed to Low Lead Levels

2008 ◽  
Vol 59 (3) ◽  
pp. 161-169 ◽  
Author(s):  
Imran Mohammad ◽  
Abbas Mahdi ◽  
Aryapu Raviraja ◽  
Islam Najmul ◽  
Ahmad Iqbal ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Status ◽  
Aminolevulinic Acid ◽  
Lead Level ◽  
Lead Toxicity ◽  
Blood Lead ◽  
Blood Lead Levels ◽  
Control Group ◽  
Zinc Protoporphyrin ◽  
Lead Levels

Oxidative Stress in Painters Exposed to Low Lead LevelsLead toxicity is a public health problem particularly to the children and to occupationally exposed adults. Evidence is mounting successively regarding the adverse health effects of lead at low levels. This study was undertaken to assess the antioxidant status of lead-exposed residential and commercial painters of Lucknow city in Uttar Pradesh, India.Thirty-five painters aged 20 to 50 years who had blood lead levels ≤400 μg L-1were selected for the study from a population of 56 male painters initially screened for blood lead. The control group included an equal number of subjects of the same age group without any occupational exposure to lead.We studied the association between low lead level exposure and antioxidant status and found that blood lead levels in painters were approximately seven times as high as in controls [(219.2 ± 61.9) μg L-1vs. (30.6±10.1) μg L-1, respectively]. Among the biomarkers of lead toxicity a significant decrease in the level of delta-aminolevulinic acid dehydratase [(9.13±4.62) UL-1vs. (39.38±5.05) UL-1] and an increase in the level of zinc protoporphyrin [(187.9±49.8) μg L-1vs. (26.4±5.5) μg L-1] were observed in painters compared to controls. Among antioxidant enzymes, painters showed a significant decrease in catalase [(56.77±11.11) UL-1vs. (230.30±42.55) UL-1] and superoxide dismutase [(0.64±0.19) UL-1 vs. (2.68±0.62) UL-1] compared to controls. Lipid peroxidation was monitored by measuring thiobarbituric acid reactive substances (TBARS) that were expressed in terms of malondialdehyde (MDA) equivalents. Concentration of MDA in plasma was higher in painters than in controls [(7.48±1.31) nmol mL-1vs. (3.08±0.56) nmol mL-1]. Significant changes were also observed in reduced and oxidised glutathione levels. The strong association between blood lead levels and oxidative stress markers in this population suggests that oxidative stress should be considered in the pathogenesis of lead-related diseases among people with low level environmental exposure to lead.

scholarly journals Effects of oxidative stress on blood pressure and electrocardiogram findings in workers with occupational exposure to lead

2019 ◽  
Vol 47 (6) ◽  
pp. 2461-2470 ◽  
Author(s):  
Wei Qu ◽  
Guo-Li Du ◽  
Bin Feng ◽  
Hua Shao
Keyword(s):  
Oxidative Stress ◽  
Blood Pressure ◽  
Lead Exposure ◽  
Blood Lead Level ◽  
Lead Level ◽  
Blood Lead ◽  
Stress Index ◽  
High Dose ◽  
Oxidative Stress Index ◽  
Two Populations

Objective To observe the correlation between the oxidative stress index and cardiovascular system damage in a population with lead exposure. Methods Two populations (144 manufacturing workers and 94 administrators) from a lead–acid battery manufacturer in Shandong Province in China were recruited. The blood lead level, oxidative stress index, blood pressure, electrocardiogram findings, and their correlations were analyzed in both groups. Results The blood lead level was significantly higher in manufacturing workers than administrators (254.34 vs. 65.32 µg/L, respectively). The differences in the oxidative stress index, serum total superoxide dismutase (T-SOD) concentration, and malondialdehyde (MDA) concentration between the two populations were statistically significant. The rates of abnormal blood pressure and electrocardiogram findings were significantly higher in manufacturing workers than administrators. Workers with middle- and high-dose lead exposure had lower T-SOD and higher MDA concentrations than those with low-dose lead exposure. Significant correlations were found between the blood lead level and the MDA concentration, systolic pressure, diastolic pressure, and electrocardiogram findings. Linear multiple regression analysis showed that T-SOD was negatively associated with blood lead, electrocardiogram findings, and MDA. Conclusion Lead exposure can lead to oxidative stress, increased blood pressure, and abnormal electrocardiogram findings and may impact cardiovascular diseases through oxidative stress.

scholarly journals Blood lead level and risk of hypertension in the United States National Health and Nutrition Examination Survey 1999–2016

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Man Fung Tsoi ◽  
Chris Wai Hang Lo ◽  
Tommy Tsang Cheung ◽  
Bernard Man Yung Cheung
Keyword(s):  
Blood Pressure ◽  
Lead Exposure ◽  
Blood Lead Level ◽  
Lead Level ◽  
Blood Lead ◽  
The United States ◽  
Study Data ◽  
Blood Lead Levels ◽  
Environmental Lead ◽  
Lead Levels

AbstractLead is a heavy metal without a biological role. High level of lead exposure is known to be associated with hypertension, but the risk at low levels of exposure is uncertain. In this study, data from US NHANES 1999–2016 were analyzed. Adults with blood lead and blood pressure measurements, or self-reported hypertension diagnosis, were included. If not already diagnosed, hypertension was defined according to the AHA/ACC 2017 hypertension guideline. Results were analyzed using R statistics version 3.5.1 with sample weight adjustment. Logistic regression was used to study the association between blood lead level and hypertension. Odds ratio (OR) and 95% confidence interval (95% CI) were estimated. Altogether, 39,477 participants were included. Every doubling in blood lead level was associated with hypertension (OR [95%CI] 1.45 [1.40–1.50]), which remained significant after adjusting for demographics. Using quartile 1 as reference, higher blood lead levels were associated with increased adjusted odds of hypertension (Quartile 4 vs. Quartile 1: 1.22 [1.09–1.36]; Quartile 3 vs. Quartile 1: 1.15 [1.04–1.28]; Quartile 2 vs. Quartile 1: 1.14 [1.05–1.25]). In conclusion, blood lead level is associated with hypertension in the general population with blood lead levels below 5 µg/dL. Our findings suggest that reducing present levels of environmental lead exposure may bring cardiovascular benefits by reducing blood pressure.

Effect of High Dose Vitamin C Supplementation on Muscle Soreness, Damage, Function, and Oxidative Stress to Eccentric Exercise

2006 ◽  
Vol 16 (3) ◽  
pp. 270-280 ◽  
Author(s):  
S.C. Bryer ◽  
A.H. Goldfarb
Keyword(s):  
Oxidative Stress ◽  
Vitamin C ◽  
Eccentric Exercise ◽  
Muscle Function ◽  
Muscle Soreness ◽  
Damage Function ◽  
High Dose ◽  
Before And After ◽  
Vitamin C Supplementation ◽  
Glutathione Oxidation

This study investigated if vitamin C supplementation before and after eccentric exercise could reduce muscle soreness (MS), oxidative stress, and muscle function. Eighteen healthy men randomly assigned to either a placebo (P) or vitamin C (VC) (3 g/d) treatment group took pills for 2 wk prior and 4 d after performing 70 eccentric elbow extensions with their non-dominant arm. MS increased in both groups with significantly reduced MS for the first 24 h with VC. Range of motion was reduced equally in both groups after the exercise (P ≥ 0.05). Muscle force declined equally and was unaffected by treatment. VC attenuated the creatine kinase (CK) increase at 48 h after exercise with similar CK after this time. Gluta-thione ratio (oxidized glutathione/total glutathione) was significantly increased at 4 and 24 h with P but VC prevented this change. These data suggest that vitamin C pretreatment can reduce MS, delay CK increase, and prevent blood glutathione oxidation with little influence on muscle function loss.

Hardness of Domestic Water and Blood Lead Levels

1983 ◽  
Vol 2 (4) ◽  
pp. 645-648 ◽  
Author(s):  
P.C. Elwood ◽  
K.M. Phillips ◽  
N. Lowe ◽  
J.K. Phillips ◽  
C. Toothill
Keyword(s):  
Blood Lead Level ◽  
Lead Level ◽  
Blood Lead ◽  
Hard Water ◽  
Control Area ◽  
Blood Lead Levels ◽  
Domestic Water ◽  
Solvent Water ◽  
Small Rise ◽  
Lead Levels

1 The effect on the blood lead levels of residents in an area in which a soft plumbo-solvent water was hardened is examined. 2 Water lead levels fell after hardening was introduced whereas there was a small rise in water lead levels in a control area monitored over the same time. 3 The blood lead levels of residents fell after hardening and the fall was slightly greater than would have been predicted on the basis of the change in water lead levels. This suggests that lead is less well absorbed from hard water than from soft water. 4 Following hardening there was a significant fall in mean blood lead level of subjects living in houses which had initially had negligible amounts of lead in the water. This suggests that hard water may interfere with the absorption of lead from sources other than water.

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