scholarly journals Activated Carbon Fabric Respiratory Mask reduces Blood Lead, Oxidative Stress and Improves the Antioxidant Status and Liver Functions in Unorganised Battery Workers

2020 ◽  
Vol 11 (4) ◽  
pp. 7247-7253
Author(s):  
Jyotsna A Patil ◽  
Mandakini S Kshirsagar ◽  
Arun J Patil
Keyword(s):  
Oxidative Stress ◽  
Superoxide Dismutase ◽  
Activated Carbon ◽  
Blood Lead Level ◽  
Antioxidant Status ◽  
Lead Level ◽  
Lipid Peroxide ◽  
Blood Lead ◽  
Carbon Fabric ◽  
Liver Functions

Effect of use of Activated Carbon Fabric (ACF) mask on blood lead (PbB), lipid peroxide, erythrocytes-Superoxide Dismutase (SOD), Catalase, Ceruloplasmin, and liver functions tests of battery manufacturing workers (BMW) were studied. For this study, 36 male battery manufacturing workers, those who are regularly using ACF mask for two months were included. A blood sample was collected before and after using ACF masks from battery manufacturing workers and estimated the blood lead level, liver function tests, oxidative stress, and antioxidant status parameters by using the standard method. After two months use of ACF mask by BMW, the blood lead level (P<0.01, -15.76%), total serum bilirubin (P<0.05, -28.09%), alanine transaminase (P<0.05, -20.84%), lipid peroxide (P<0.001, -33.33%) were significantly decreased and erythrocytes-superoxide dismutase (P<0.05, 22.38%), catalase (P<0.05, 38.39%), ceruloplasmin (P<0.05, 13.13%) were significantly increased in battery manufacturing workers as compared to before using the mask. This study reflects the use of two months ACF mask of high lead-exposed workers are useful to decrease lead absorption, which results in decreases oxidative stress and improves the antioxidant status and prevents liver toxicity.

scholarly journals Elevated Blood Lead Results in oxidative stress and Alters the Antioxidants of Silver Jewellery labors

2020 ◽  
Vol 11 (4) ◽  
pp. 7254-7258
Author(s):  
Mandakini S. Kshirsagar ◽  
Arun J. Patil ◽  
Jyotsna A. Patil
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Superoxide Dismutase ◽  
Antioxidant Enzymes ◽  
Lead Level ◽  
Lipid Peroxide ◽  
Blood Lead ◽  
Carbon Fabric ◽  
Age Range ◽  
Male Subjects

This study is designed to find out the present status of PbB level and its adverse effect on oxidative stress and antioxidant  of Silver Jewellery Workers (SJW). Forty-two SJW of having an age range of 20-45 years were included for this study and compared with 50 healthy male subjects of the same age-matched. All biochemical investigations were determined by using standard methods. In this study, we found significantly increased PbB level (325%), serum lipid peroxide (191%) and significantly decreased antioxidant enzymes like superoxide dismutase (-37.83%), Catalase (-27.64%), Ceruloplasmin (-10.2%), Nitric oxide (-36.54%) in silver jewellery workers as compared to control subjects. PbB level positively correlated with lipid peroxide (0.46) and negatively correlated with superoxide dismutase (-0.31), Catalase (-0.30), Ceruloplasmin (-0.20) and Nitric oxide (-0.28) were observed in study subjects.  Therefore we have planned this study to know the oxidative stress and antioxidant status of silver jewellery workers and we found that blood lead level results in oxidative stress and alters antioxidant enzymes of silver jewellery workers and to reduce this oxidative stress it is indispensable to decrease PbB level of silver jewellery workers by taking vitamins, minerals and using activated carbon fabric mask which can prevent the health hazards of lead.

Role of activated carbon fabric mask to prevent lead absorption – a short report

2008 ◽  
Vol 24 (9) ◽  
pp. 569-572 ◽  
Author(s):  
A Kuruvilla ◽  
VV Pillay ◽  
P Adhikari ◽  
T Venkatesh ◽  
M Chakrapani ◽  
...  
Keyword(s):  
Activated Carbon ◽  
Blood Lead Level ◽  
Lead Level ◽  
Blood Lead ◽  
Blood Lead Levels ◽  
Short Report ◽  
Carbon Fabric ◽  
Lead Absorption ◽  
Before And After ◽  
Lead Levels

An attempt was made to study the usefulness of activated carbon fabric (ACF) mask to prevent lead absorption. Indigenous ACF masks were provided to eight workers involved in the manufacture of batteries. Their blood lead levels were determined before and after using these masks. There was a substantial decrease in blood lead level after using the mask among those who were under treatment for high blood lead levels. Three workers who were not under treatment for lead also showed a decrease in blood lead level, after using this ACF mask, suggesting the usefulness of ACF in preventing further exposure. Such a study has not been reported anywhere in the available literature and similar such studies with more number of masks is necessary to evaluate its effectiveness.

scholarly journals Environmental Lead Exposure, Catalase Gene, and Markers of Antioxidant and Oxidative Stress Relation to Hypertension: An Analysis Based on the EGAT Study

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Jintana Sirivarasai ◽  
Sukhumpun Kaojarern ◽  
Suwannee Chanprasertyothin ◽  
Pachara Panpunuan ◽  
Krittaya Petchpoung ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lead Exposure ◽  
Blood Lead Level ◽  
Lead Level ◽  
Blood Lead ◽  
Cross Sectional Study ◽  
Oxidative Stress Marker ◽  
Blood Levels ◽  
Cross Sectional ◽  
Cat Gene

Lead has been linked to the development of hypertension via oxidative stress. Catalase plays an important role in the disposal of hydrogen peroxide in erythrocyte and its activity was determined by CAT gene. The aims of this study were to investigate (1) the association between blood levels of antioxidant markers such as catalase, superoxide dismutase, glutathione, glutathione peroxidase, oxidative stress-marker (malondialdehyde), and blood lead level and (2) the influence of genetic polymorphism of CAT gene (rs769217) on change in blood pressure in general population of EGAT study project. This is a cross-sectional study of 332 normotensive, 432 prehypertensive, and 222 hypertensive male subjects. Hypertensive subjects had significantly higher blood lead level (5.28 μg/dL) compared to normotensive (4.41 μg/dL) and prehypertensive (4.55 μg/dL) subjects (P<0.05). These significant findings are also found in MDA levels. Moreover, individuals with TT genotype in hypertensive group had significantly higher blood lead and MDA levels (6.06 μg/dL and 9.67 μmol/L) than those with CC genotype (5.32 μg/dL and 8.31 μmol/L,P<0.05). Our findings suggested that decreased blood catalase activity in this polymorphism together with low level lead exposure induced lipid peroxidation may be responsible for hypertension.

Biochemical effects of lead exposure on oxidative stress and antioxidant status of battery manufacturing workers of Western Maharashtra, India

2016 ◽  
Vol 27 (2) ◽  
Author(s):  
Ganesh Haribhau Ghanwat ◽  
Arun Jalindar Patil ◽  
Jyotsna A. Patil ◽  
Mandakini S. Kshirsagar ◽  
Ajit Sontakke ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lead Exposure ◽  
Antioxidant Status ◽  
Lipid Peroxide ◽  
Blood Lead ◽  
Control Group ◽  
Oxidative Stress Parameter ◽  
Control Subjects ◽  
Antioxidant Parameters ◽  
Current Scenario

AbstractLead induces oxidative stress and alters the antioxidant status of population exposed to high lead levels, i.e. battery manufacturing workers. The aim of this study was to know the current scenario of blood lead (PbB) levels and their effect on the oxidative stress parameter, i.e. serum lipid peroxide (LP), and antioxidant parameters, such as red blood cell (RBC)-superoxide dismutase (SOD), RBC-catalase (CAT), plasma ceruloplasmin (CP), and serum nitrite, of battery manufacturing workers.Forty-three battery manufacturing workers from Western Maharashtra, India, with ages between 19 and 42 years, were selected as study group and compared with 38 age-matched, healthy male subjects (control group). From both group subjects, 10 mL of blood sample was drawn by puncturing the antecubital vein, and PbB, serum LP, RBC-SOD, RBC-CAT, plasma CP, and serum nitrite were estimated using standard methods.The PbB levels of the battery manufacturing workers were significantly higher (p<0.001, 1050%) as compared with the control subjects. The serum LP levels were significantly increased (p<0.001, 96.86%); all antioxidant status parameters such as RBC-SOD (p<0.001, –26.32%), RBC-CAT (p<0.001, –51.57%), and plasma CP (p<0.001, –35.13%) were significantly decreased; and serum nitrite levels (p<0.001, 154%) were significantly increased in the battery manufacturing workers as compared with the control subjects.Despite modern techniques used to reduce lead exposure in battery manufacturing workers, PbB levels remain high, inducing oxidative stress and altering the antioxidant status of battery manufacturing workers.

Increased blood lead level induces oxidative stress and alters the antioxidant status of spray painters

2020 ◽  
Vol 31 (2) ◽  
Author(s):  
Mandakini S. Kshirsagar ◽  
Jyotsna A. Patil ◽  
Arun Patil
Keyword(s):  
Nitric Oxide ◽  
Uric Acid ◽  
Serum Lipid ◽  
Blood Lead Level ◽  
Lead Level ◽  
Lipid Peroxide ◽  
Blood Lead ◽  
Elevated Blood ◽  
Serum Lipid Peroxide ◽  
Antioxidant Parameters

AbstractBackgroundThe aim of this study was to know the present scenario of blood lead level and its effect on serum lipid peroxide and antioxidant parameters of spray painters.MethodsWe included 42 male spray painters and 50 control subjects with an age range of 20–45 years. Blood lead level, serum lipid peroxide and antioxidant parameters, i.e. erythrocyte catalase, superoxide dismutase (SOD), plasma ceruloplasmin, nitric oxide, uric acid and bilirubin, were quantified by standard methods.ResultsWe observed the significant elevated blood lead (p < 0.001, 458%), lipid peroxide (p < 0.001, 170%), uric acid (p < 0.001, 25.6%) and bilirubin (p < 0.01, 24.5%) and the significant decrease in antioxidant enzymes like SOD (p < 0.001, −50.4%), catalase (p < 0.001, −34.33%), ceruloplasmin (p < 0.001, −32.7%) and nitric oxide (p < 0.001, −39.58%) in the study group as compared to control. A significant positive correlation coefficient (r) of blood lead level with lipid peroxide (r = 0.44, p < 0.001), uric acid (r = 0.33 p < 0.05) and bilirubin (r = 0.35, p < 0.05) and a negative correlation with SOD (r = −0.32, p < 0.05), catalase (r = −0.33, p < 0.05), ceruloplasmin (r = −0.27, p < 0.05) and nitric oxide (r = 0.30, p < 0.05) were observed.ConclusionsElevated blood lead level induces serum lipid peroxide and alters the antioxidant enzymes of spray painters. Therefore, it is necessary to reduce the blood lead level by taking proper precautions while spraying the paints, and additional antioxidant supplementation like vitamin C, multivitamin and multiminerals will be useful in reducing oxidative stress.

scholarly journals Oxidative Stress in Painters Exposed to Low Lead Levels

2008 ◽  
Vol 59 (3) ◽  
pp. 161-169 ◽  
Author(s):  
Imran Mohammad ◽  
Abbas Mahdi ◽  
Aryapu Raviraja ◽  
Islam Najmul ◽  
Ahmad Iqbal ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Status ◽  
Aminolevulinic Acid ◽  
Lead Level ◽  
Lead Toxicity ◽  
Blood Lead ◽  
Blood Lead Levels ◽  
Control Group ◽  
Zinc Protoporphyrin ◽  
Lead Levels

Oxidative Stress in Painters Exposed to Low Lead LevelsLead toxicity is a public health problem particularly to the children and to occupationally exposed adults. Evidence is mounting successively regarding the adverse health effects of lead at low levels. This study was undertaken to assess the antioxidant status of lead-exposed residential and commercial painters of Lucknow city in Uttar Pradesh, India.Thirty-five painters aged 20 to 50 years who had blood lead levels ≤400 μg L-1were selected for the study from a population of 56 male painters initially screened for blood lead. The control group included an equal number of subjects of the same age group without any occupational exposure to lead.We studied the association between low lead level exposure and antioxidant status and found that blood lead levels in painters were approximately seven times as high as in controls [(219.2 ± 61.9) μg L-1vs. (30.6±10.1) μg L-1, respectively]. Among the biomarkers of lead toxicity a significant decrease in the level of delta-aminolevulinic acid dehydratase [(9.13±4.62) UL-1vs. (39.38±5.05) UL-1] and an increase in the level of zinc protoporphyrin [(187.9±49.8) μg L-1vs. (26.4±5.5) μg L-1] were observed in painters compared to controls. Among antioxidant enzymes, painters showed a significant decrease in catalase [(56.77±11.11) UL-1vs. (230.30±42.55) UL-1] and superoxide dismutase [(0.64±0.19) UL-1 vs. (2.68±0.62) UL-1] compared to controls. Lipid peroxidation was monitored by measuring thiobarbituric acid reactive substances (TBARS) that were expressed in terms of malondialdehyde (MDA) equivalents. Concentration of MDA in plasma was higher in painters than in controls [(7.48±1.31) nmol mL-1vs. (3.08±0.56) nmol mL-1]. Significant changes were also observed in reduced and oxidised glutathione levels. The strong association between blood lead levels and oxidative stress markers in this population suggests that oxidative stress should be considered in the pathogenesis of lead-related diseases among people with low level environmental exposure to lead.

scholarly journals Effects of oxidative stress on blood pressure and electrocardiogram findings in workers with occupational exposure to lead

2019 ◽  
Vol 47 (6) ◽  
pp. 2461-2470 ◽  
Author(s):  
Wei Qu ◽  
Guo-Li Du ◽  
Bin Feng ◽  
Hua Shao
Keyword(s):  
Oxidative Stress ◽  
Blood Pressure ◽  
Lead Exposure ◽  
Blood Lead Level ◽  
Lead Level ◽  
Blood Lead ◽  
Stress Index ◽  
High Dose ◽  
Oxidative Stress Index ◽  
Two Populations

Objective To observe the correlation between the oxidative stress index and cardiovascular system damage in a population with lead exposure. Methods Two populations (144 manufacturing workers and 94 administrators) from a lead–acid battery manufacturer in Shandong Province in China were recruited. The blood lead level, oxidative stress index, blood pressure, electrocardiogram findings, and their correlations were analyzed in both groups. Results The blood lead level was significantly higher in manufacturing workers than administrators (254.34 vs. 65.32 µg/L, respectively). The differences in the oxidative stress index, serum total superoxide dismutase (T-SOD) concentration, and malondialdehyde (MDA) concentration between the two populations were statistically significant. The rates of abnormal blood pressure and electrocardiogram findings were significantly higher in manufacturing workers than administrators. Workers with middle- and high-dose lead exposure had lower T-SOD and higher MDA concentrations than those with low-dose lead exposure. Significant correlations were found between the blood lead level and the MDA concentration, systolic pressure, diastolic pressure, and electrocardiogram findings. Linear multiple regression analysis showed that T-SOD was negatively associated with blood lead, electrocardiogram findings, and MDA. Conclusion Lead exposure can lead to oxidative stress, increased blood pressure, and abnormal electrocardiogram findings and may impact cardiovascular diseases through oxidative stress.

scholarly journals Blood lead level and risk of hypertension in the United States National Health and Nutrition Examination Survey 1999–2016

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Man Fung Tsoi ◽  
Chris Wai Hang Lo ◽  
Tommy Tsang Cheung ◽  
Bernard Man Yung Cheung
Keyword(s):  
Blood Pressure ◽  
Lead Exposure ◽  
Blood Lead Level ◽  
Lead Level ◽  
Blood Lead ◽  
The United States ◽  
Study Data ◽  
Blood Lead Levels ◽  
Environmental Lead ◽  
Lead Levels

AbstractLead is a heavy metal without a biological role. High level of lead exposure is known to be associated with hypertension, but the risk at low levels of exposure is uncertain. In this study, data from US NHANES 1999–2016 were analyzed. Adults with blood lead and blood pressure measurements, or self-reported hypertension diagnosis, were included. If not already diagnosed, hypertension was defined according to the AHA/ACC 2017 hypertension guideline. Results were analyzed using R statistics version 3.5.1 with sample weight adjustment. Logistic regression was used to study the association between blood lead level and hypertension. Odds ratio (OR) and 95% confidence interval (95% CI) were estimated. Altogether, 39,477 participants were included. Every doubling in blood lead level was associated with hypertension (OR [95%CI] 1.45 [1.40–1.50]), which remained significant after adjusting for demographics. Using quartile 1 as reference, higher blood lead levels were associated with increased adjusted odds of hypertension (Quartile 4 vs. Quartile 1: 1.22 [1.09–1.36]; Quartile 3 vs. Quartile 1: 1.15 [1.04–1.28]; Quartile 2 vs. Quartile 1: 1.14 [1.05–1.25]). In conclusion, blood lead level is associated with hypertension in the general population with blood lead levels below 5 µg/dL. Our findings suggest that reducing present levels of environmental lead exposure may bring cardiovascular benefits by reducing blood pressure.

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