scholarly journals Oxidative Stress Markers (8-Isoprostane and 8-Hydroxy-2-Deoxyguanosine) in Major Depression: A Case-control Study

2021 ◽  
Author(s):  
Parul Chopra ◽  
Rajesh Sagar ◽  
Asok Kumar Mukhopadhyay
Keyword(s):  
Oxidative Stress ◽  
Major Depression ◽  
Oxidative Damage ◽  
Case Control Study ◽  
Case Control ◽  
Clinical Severity ◽  
Healthy Controls ◽  
Oxidative Stress Markers ◽  
Stress Markers ◽  
Control Study

Introduction: Depression is associated with activation of innate immune response leading to oxidative damage. The 8-isoprostanes and 8-hydroxy-2-deoxyguanosine (8-OHdG) are biomarkers of oxidative damage to lipids and Deoxyribonucleic Acid (DNA), respectively. They have been independently linked to depression. Aim: To study the oxidative stress markers (8-Isoprostanes and 8-OHdG) in subjects with major depression. Materials and Methods: In this observational case-control study 42 cases of depression, 13-25 years of age were recruited from Psychiatry Out Patient Department (OPD) at a tertiary-care hospital in Delhi, India, along with 42 healthy controls. They were assessed clinically and using psychometric evaluation scores, Beck’s Depression Inventory-II (BDI-II) and Hamilton Depression Rating Scale (HAM-D). All 42 subjects were on medication with antidepressants {33/42 with Selective Serotonin Reuptake Inhibitors (SSRI) 8/42 with Tricyclic Antidepressants (TCA) and 1/42 on a combination of both}. Routine laboratory investigations were done. Plasma 8-Isoprostane and serum 8-OHdG concentrations were measured in both cases and controls. The results obtained were analysed using relevant statistical tests on STATA version 11 (StataCorp, 2009). Results: Clinically, all patients had moderate to severe depression. BDI-II and HAM-D scores were raised in all cases as compared to the controls (28.81±5.60 vs 1.62±1.59 for BDI and 20.88±4.67 vs 1.33±1.43 for HAM-D, respectively). The concentration (in depressed vs controls) of plasma 8-Isoprostane (107.70±54.48 pg/mL vs 77.78±60.15 pg/mL) and serum 8-OHdG (2103.03±154 pg/mL vs 2017±164.69 pg/mL) were significantly elevated (p-value <0.05). Though elevated in patients belonging to both genders, showed significant increase of 8-Isoprostane only in females and 8-OHdG only in males as compared to their healthy controls. No correlation of the levels of any of two markers was seen with clinical severity of depression of patients as assessed by BDI. Conclusion: Evidence of oxidative stress to lipids and DNA are present in the peripheral blood. These can be explored further in establishing the biomarkers for diagnosis and prognosis of depression.

scholarly journals Methamphetamine’s effects on oxidative stress markers may continue after detoxification: a case–control study

2019 ◽  
Vol 29 (3) ◽  
pp. 361-367
Author(s):  
Yunus Hacimusalar ◽  
Ozgul Karaaslan ◽  
Ceylan Bal ◽  
Derya Kocer ◽  
Gamze Gok ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Case Control Study ◽  
Case Control ◽  
Oxidative Stress Markers ◽  
Stress Markers ◽  
Control Study

Oxidative stress markers in pregnant women who snore and fetal outcome: a case control study

2007 ◽  
Vol 86 (11) ◽  
pp. 1317-1321 ◽  
Author(s):  
Gülengül Köken ◽  
Figen Kir Sahin ◽  
Emine Cosar ◽  
Filiz Saylan ◽  
Nigar Yilmaz ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Pregnant Women ◽  
Case Control Study ◽  
Fetal Outcome ◽  
Case Control ◽  
Oxidative Stress Markers ◽  
Stress Markers ◽  
Control Study

scholarly journals The relationship between oxidative stress markers and endometrial hyperplasia: A case-control study

2021 ◽  
Vol 18 (4) ◽  
pp. 298-303
Author(s):  
Engin Yıldırım ◽  
Can Türkler ◽  
Ümit Görkem ◽  
Ömer Yavuz Şimşek ◽  
Ercan Yılmaz ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Endometrial Hyperplasia ◽  
Case Control Study ◽  
Case Control ◽  
Oxidative Stress Markers ◽  
Stress Markers ◽  
The Relationship ◽  
Control Study

Oxidative Stress Markers in Pregnant Women Who Snore and Fetal Outcome: A Case Control Study

2008 ◽  
Vol 28 (2) ◽  
pp. 101
Author(s):  
G. Köken ◽  
F.K. Sahin ◽  
E. Cosar ◽  
F. Saylan ◽  
N. Yilmaz ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Pregnant Women ◽  
Case Control Study ◽  
Fetal Outcome ◽  
Case Control ◽  
Oxidative Stress Markers ◽  
Stress Markers ◽  
Control Study

scholarly journals The significance of the oxidative stress markers in the one-year prognosis of patients with acute ischemic stroke: a case-control study

BMC Neurology ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Sheida Shaafi ◽  
Fina Hadisi ◽  
Mahsa Mahmoudinezhad ◽  
Hamidreza Razmi ◽  
Seyed Aria Nejadghaderi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Case Control Study ◽  
Case Control ◽  
Stroke Severity ◽  
Oxidative Stress Markers ◽  
Stress Markers ◽  
Control Study

Abstract Background Stroke is a major cause of mortality and morbidity. Also, free radicals and oxidative stress are deleterious factor in the stroke progression. We aimed to evaluate the association between oxidative stress markers and odds of having risk factor for stroke or developing stroke. Methods The present case-control study was conducted on 556 participants in Imam-Reza hospital, Tabriz, Iran. Subjects were divided into three group, including individuals with acute ischemic stroke, those who were at risk of stroke, and healthy controls. All enrolled participants except for controls underwent neurological examinations and brain magnetic resonance imaging (MRI). Stroke-related disability and stroke severity were evaluated by modified Rankin Scale (mRS) and National Institutes of Health Stroke Scale (NIHSS), respectively. Serum malondialdehyde (MDA) level and total antioxidant capacity (TAC) were measured within 48 h of the initiation of stroke. One-way ANOVA and Chi-square tests were used for comparing characteristics between groups. Multivariable logistic regression was implemented for odds of stroke based on MDA and TAC quartiles. Also, Spearman’s correlation was utilized. Results Serum MDA, systolic and diastolic blood pressure, cholesterol, and triglyceride were significantly higher in the stroke group than controls. High levels of MDA were associated with increased development of stroke (P-value < 0.001), however TAC and MDA were not associated with having risk factors for stroke (P-value = 1.00 and 0.27, respectively). Also, TAC level was negatively associated with baseline (ρ = − 0.28; P-value = 0.04) and follow-up (ρ = − 0.31; P-value = 0.03) NIHSS scores. Moreover, MDA was correlated with mRS score at follow-up (ρ = − 0.26; P-value = 0.04). Conclusions The balance between antioxidants and oxidants markers might reveal a new approach in this context. Further studies are warranted to identify the source of oxidative stress as well as cessation of the production of oxygen radicals in stroke.

scholarly journals Cerebrospinal fluid oxidative stress metabolites in patients with bipolar disorder and healthy controls: a longitudinal case-control study

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Ulla Knorr ◽  
Anja Hviid Simonsen ◽  
Peter Roos ◽  
Allan Weimann ◽  
Trine Henriksen ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Bipolar Disorder ◽  
Cerebrospinal Fluid ◽  
Case Control Study ◽  
Case Control ◽  
Oxidative Stress Markers ◽  
Stress Markers ◽  
Rna Damage ◽  
Control Study

AbstractBipolar disorder (BD) is a mental disorder characterized by recurrent relapses of affective episodes, cognitive impairment, illness progression, and reduced life expectancy. Increased systemic oxidatively generated nucleoside damage have been found in some neurodegenerative disorders and in BD. As the first, this naturalistic prospective, longitudinal follow-up case-control study investigated cerebrospinal fluid (CSF) oxidative stress markers 8-oxo-7,8-dihydroguanosine (8-oxoGuo) and 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodG) that relate to RNA and DNA damage, respectively. Patients with BD (n = 86, 51% female) and gender-and-age-matched healthy control individuals (HC; n = 44, 44% female) were evaluated at baseline (T0), during (T1) and after a new affective episode (T2), if it occurred, and after a year (T3). Cerebrospinal and urine oxidative stress markers were analyzed using ultra-performance liquid chromatography–tandem mass spectrometry. CSF-8-oxoGuo was statistically significantly higher by 18% (p = 0.003) in BD versus HC at T0, and by 22% (p = 0) at T3. CSF-8-oxoGuo had increased by 15% (p = 0.042) from T0 to T3, and by 14% (p = 0.021) from T2 to T3 in patients, who experienced an episode during follow-up. CSF-8-oxodG had increased by 26% (p = 0.054) from T0 to T2 and decreased by 19% (p = 0.041) from T2 to T3 in patients, who experienced an episode during follow-up. CSF-8-oxoGuo did not show a statistically significant change in HC during the one-year follow-up. CSF and urine-8-oxoGuo levels correlated moderately. In conclusion, CSF oxidative stress marker of RNA damage 8-oxoGuo showed both state and trait dependence in BD and stability in HC. Central RNA damage may be a potential biomarker for BD.

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