scholarly journals Chlorpromazine and Trifluperazine Induced Parkinsonism in a Patient with Insomnia

2021 ◽  
Author(s):  
S Girija ◽  
N Naresh Kumar ◽  
N Natis Prasannaa ◽  
S Sarumathy ◽  
R Nanda Kumar
Keyword(s):  
Calcium Channel ◽  
Antiepileptic Drugs ◽  
Female Patient ◽  
Antipsychotic Medication ◽  
Calcium Channel Blockers ◽  
Atypical Antipsychotics ◽  
Psychiatric Clinic ◽  
Channel Blockers ◽  
Drug Induced ◽  
Muscular Rigidity

Drug Induced Parkinsonism (DIP) can be described as reversible development of Parkinsonian syndrome in patients treated with drugs which impair dopamine function. It includes symptoms such as tremor, muscular rigidity and bradykinesia. Gastrointestinal prokinetics, calcium channel blockers, modern atypical antipsychotics, and antiepileptic drugs may cause DIP. This report is about a 40-year-old female patient who developed a DIP after taking the antipsychotic medication combination (chlorpromazine and trifluperazine) for insomnia after being prescribed from a psychiatric clinic. After four weeks of initiation of treatment, she developed tremors, muscular rigidity and slowness in movements. The patient was admitted with the following complaints and then the drugs chlorpromazine and trifluperazine were stopped. The patient was then treated with tablet levodopa and carbidopa 110 mg, trihexiphenidyl 2 mg and tablet alprazolam 0.25 mg after which she gradually improved and was feeling better after a week. Atypical antipsychotics indicated for psychiatric disorders have high potential to cause extrapyramidal symptoms. Hence, for the treatment of insomnia newer drugs such as zolpidem and zaleplon can be used to minimise the chances of occurrence of DIP.

scholarly journals Role of calcium channel blocker in excessive mast cell degranulation

2021 ◽  
Vol 5 (7) ◽  
Author(s):  
Sagarika Datta
Keyword(s):  
Mast Cell ◽  
Peripheral Neuropathy ◽  
Anxiety Disorder ◽  
Calcium Channel ◽  
Female Patient ◽  
Calcium Channel Blockers ◽  
Channel Blocker ◽  
Mast Cell Degranulation ◽  
Channel Blockers

Here, I present a case of a female patient, age 45 years, for whom the uncontrolled mast cell degranulation created many issues related to allergy like, skin rash, itching, breathing discomfort, frequent throat infection, GERD, migraine, fibromyalgia, peripheral neuropathy, depression, anxiety disorder, constipation etc. For the patient, it was observed that calcium channel blockers seem to control the unnecessary and uncontrolled mast cell degranulation. CCB seemed to have a role to play in mast cell degranulation.

scholarly journals Cyclosporine A and amlodipine induced gingival overgrowth in a kidney transplant recipient: case presentation with literature review

2019 ◽  
Vol 12 (5) ◽  
pp. e229587 ◽  
Author(s):  
Tarun Nanda ◽  
Baljeet Singh ◽  
Parul Sharma ◽  
Karandeep Singh Arora
Keyword(s):  
Calcium Channel ◽  
Kidney Transplant ◽  
Cyclosporine A ◽  
Calcium Channel Blockers ◽  
Kidney Transplant Recipient ◽  
Kidney Transplant Patient ◽  
Channel Blockers ◽  
Drug Induced ◽  
Gingival Overgrowth ◽  
Gingival Enlargement

Drug-induced gingival overgrowth is a condition caused by side effects of treatment with one of three types of drugs: phenytoin (used in epilepsy treatment), cyclosporine A (used in transplantology after allogenic organ transplants) and calcium channel blockers (used in the treatment of hypertension). Gingival overgrowth leads to inflammation within the gums and periodontium and can amplify the existing periodontal disease leading to tooth loss. Patients who have undergone kidney transplant are given immunosuppressants to prevent transplant rejection and mostly it is accompanied with calcium channel blockers to treat hypertension associated with kidney transplant. This article reports a case of recent gingival enlargement associated with cyclosporine A and amlodipine given to a kidney transplant patient from the past 11 years.

scholarly journals Drug-induced atrial fibrillation associated with admission of cardiovascular medications

2020 ◽  
pp. 5-13
Author(s):  
O.D. Ostroumova ◽  
◽  
M.S. Chernyaeva ◽  
A.G. Komarova ◽  
S.V. Gorbatenkova ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Cardiovascular Disease ◽  
Literature Review ◽  
Calcium Channel ◽  
Elderly People ◽  
Calcium Channel Blockers ◽  
Antiplatelet Agents ◽  
Channel Blockers ◽  
Drug Induced ◽  
Cardiovascular Medications

Admission of certain medications (drugs) can cause the development of atrial fibrillation (AF) in patients having non-evident cardiovascular disease (CVD). Also, it can accelerate the onset of AF in patients with pre-existing CVD. It is important to realize medications as potential cause of AF, especially in elderly people, since aging is associated with comorbidity and use of many medications simultaneously, that can lead to higher incidence of druginduced AF (DI AF). The article provides literature review on medications used to treat CVD, the admission of which can lead to the development of DI AF. Its onset can be associated with the use of cardiotonic, antiarrhythmic and antianginal medications, calcium channel blockers, diuretics, antiplatelet agents and some others with different evidence levels. The frequency, mechanisms of DI AF development and methods for its correction are described.

scholarly journals Laser Therapy In Drug Induced Gingival Hyperplasia- A Case Report

2021 ◽  
Vol 1 (2) ◽  
Keyword(s):  
Case Report ◽  
Calcium Channel ◽  
Laser Therapy ◽  
Calcium Channel Blockers ◽  
Treatment Modalities ◽  
Personal Satisfaction ◽  
Channel Blockers ◽  
Gingival Hyperplasia ◽  
Bacterial Burden ◽  
Drug Induced

Gingival excess is related with various components including innate infections, hormonal unsettling influences, helpless oral cleanliness condition, aggravation, neoplastic conditions, and unfavorable medication responses including anticonvulsants, calcium channel blockers, and immunosuppressants. This can have an inconvenient impact on the personal satisfaction and furthermore on high oral bacterial burden brought about by plaqueretentive regions. Different treatment modalities incorporate both careful (gingivectomy, periodontal fold, electrosurgery, and laser extraction) and nonsurgical methodologies. This case report reveals the treatment of drug induced gingival hyperplasia with laser

EFFECTIVENESS OF NON-SURGICAL PERIODONTAL THERAPY ON AMLODIPINE INDUCED GINGIVAL ENLARGEMENT: A CASE REPORT

2019 ◽  
Vol 3 (11) ◽  
Author(s):  
Dagar Mona ◽  
Kataria Prerna
Keyword(s):  
Case Report ◽  
Calcium Channel ◽  
Calcium Channel Blockers ◽  
Normal State ◽  
Periodontal Therapy ◽  
Channel Blockers ◽  
Scaling And Root Planing ◽  
Drug Induced ◽  
Gingival Overgrowth ◽  
Gingival Enlargement

Gingival enlargement, [sometimes abbreviated to GO (gingival overgrowth)] is an increase in the size of the gingiva. It is a common feature of gingival disease. Gingival enlargement is a well known side-effect of drugs like anticonvulsants, calcium channel blockers and immunosuppressant. A case of amlodipine induced gingival enlargement was reported and after drug substitution when the patient was treated non-surgically (scaling and root planing), the enlargement subsides to a normal state which suggested the effectiveness of non-surgical periodontal therapy in the treatment of drug induced gingival enlargement. Keywords: Anticonvulsants, Immunosuppressants, Calcium channel blockers, gingival enlargement

scholarly journals A rare case of accelerated gingival overgrowth with high dose amlodipine therapy

2021 ◽  
Vol 2 (1) ◽  
pp. 39-41
Author(s):  
Rakesh B M ◽  
Sahithi Sharma ◽  
Chandana K H
Keyword(s):  
Calcium Channel ◽  
Calcium Channel Blockers ◽  
Rare Case ◽  
Immunosuppressive Drugs ◽  
High Dose ◽  
Channel Blockers ◽  
Gingival Hyperplasia ◽  
Limited Evidence ◽  
Drug Induced ◽  
Gingival Overgrowth

Introduction: Gingival overgrowth represents an over-exuberant response to a variety of local and systemic conditions. Certain anticonvulsants, immunosuppressive drugs, and a number of calcium channel blockers have been shown to produce similar gingival overgrowth in susceptible patients. Case report: We report a case of accelerated drug-induced gingival overgrowth in a 60-year-old hypertensive patient taking amlodipine at a dose of 10 mg. Conclusions: Among the calcium channel blockers, nifedipine is most frequently associated with gingival overgrowth.  Whereas, there is limited evidence of amlodipine-induced gingival hyperplasia.

scholarly journals Phenytoin-Induced Gingival Overgrowth: A Review of the Molecular, Immune, and Inflammatory Features

2011 ◽  
Vol 2011 ◽  
pp. 1-8 ◽  
Author(s):  
Jôice Dias Corrêa ◽  
Celso Martins Queiroz-Junior ◽  
José Eustáquio Costa ◽  
Antônio Lúcio Teixeira ◽  
Tarcilia Aparecida Silva
Keyword(s):  
Extracellular Matrix ◽  
Calcium Channel ◽  
Calcium Channel Blockers ◽  
Side Effect ◽  
Channel Blockers ◽  
Connective Tissues ◽  
Drug Induced ◽  
Gingival Overgrowth ◽  
Matrix Metabolism

Gingival overgrowth (GO) is a side effect associated with some distinct classes of drugs, such as anticonvulsants, immunosuppressant, and calcium channel blockers. GO is characterized by the accumulation of extracellular matrix in gingival connective tissues, particularly collagenous components, with varying degrees of inflammation. One of the main drugs associated with GO is the antiepileptic phenytoin, which affects gingival tissues by altering extracellular matrix metabolism. Nevertheless, the pathogenesis of such drug-induced GO remains fulfilled by some contradictory findings. This paper aims to present the most relevant studies regarding the molecular, immune, and inflammatory aspects of phenytoin-induced gingival overgrowth.

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