scholarly journals Distribution of Apolipoprotein A1 Polymorphism (G-75A and C+83T) in Patients with Diabetic Foot Ulcers-A Parallel Group Hospital Based Observational Study

2021 ◽  
Author(s):  
Rachita Nanda ◽  
Suprava Patel ◽  
Preetam Wasnik ◽  
Radhakrishna Ramchandani ◽  
Debajyoti Mohanty ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Observational Study ◽  
Diabetic Foot ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Serum Levels ◽  
Apolipoprotein A1 ◽  
Low Grade ◽  
Parallel Group

Introduction: Diabetic Foot Ulcer (DFU), a serious complications of diabetes mellitus is a result of persistent low grade infection. The Apolipoprotein A1 (ApoA1) has an anti-inflammatory role and therefore can influence the chronic inflammation associated with the DFU. Polymorphisms of ApoA1gene have been implicated as determinants of plasma HDL-C and Apo A1 levels. However, the influence of ApoA1 polymorphism on susceptibility to DFU has not been studied. Aim: To study the distribution of ApoA1 polymorphism (G-75A and C+83T) and association between the polymorphism and the risk of DFU in patients with Type 2 Diabetes Mellitus (T2DM) so that timely detection and prevention of DFU can be done. Materials and Methods: This was a hospital based observational study on patients of DFU (n=80), diabetes mellitus without ulcers (n=80) and normal controls (n=75). ApoA1 polymorphism (G-75A and C+83T) was detected by Real Time Polymerase Chain Reaction (RTPCR) technique and plasma ApoA1 by immunoturbidimetric assay using blood collected in EDTA. Data was analysed using IBM® Statistical Package for Social Sciences (SPSS) 21.0 software. A p<0.05 was considered as statistically significant. Results: The GA and CC were the most predominant genotype in all the groups. HDL and ApoA1 were significantly lower in GG (p=0.009, p=0.03) and CT (p=0.03, p=0.002) compared to GA and CC. The APOA1-75A allele and +83C allele were associated with raised levels of HDL and ApoA1 in T2DM and DFU (p<0.05). Conclusion: The two polymorphism G-75A and C+83T were found to be equally distributed across the study populations. These polymorphisms were associated with serum levels of ApoA1 and HDL in the DFU patients.

scholarly journals Comparison Pai-1 Level in Type 2 Diabetes Mellitus with and Without Diabetic Foot Ulcer

2018 ◽  
Vol 1 (1) ◽  
pp. 1-5
Author(s):  
Alfi Dewi Sholat ◽  
Dairion Gatot ◽  
Savina Handayani ◽  
Andri Iskandar Mardia ◽  
Santi Syafril
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Diabetic Foot ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Diabetic Patients ◽  
Significant Difference ◽  
Pai 1

In type 2 diabetes mellitus, there are changes in hemostasis components, including overexpression of PAI-1. By these facts, the authors are interested in conducting the study of PAI-1 level in diabetic patients with and without foot ulcer. Methods: The sample of this research was collected cross-sectionally on 20 type 2 diabetic patients with foot ulcer and 20 without foot ulcer. Blood samples were taken to measure serum PAI-1 level, complete blood count and hemostasis screening test. Results: Statistical analysis showed there are significant differences in hemoglobin, trombosit, Fibrinogen and D-dimer levels in the ulcer and non-ulcer groups but no significant difference in PAI-1 level. Conclusions: No higher PAI – 1 level were found in diabetic foot ulcer group than those without diabetic foot ulcer. There was no significant difference between PAI-1 level and grade of diabetic foot ulcer.

scholarly journals DIABETIC FOOT ULCER

2018 ◽  
Vol 25 (10) ◽  
pp. 1498-1502
Author(s):  
Zohaib Feroz ◽  
Abdul Raheem Memon ◽  
Nisar Ahmed Shah ◽  
Syed Zulfiquar Ali Shah
Keyword(s):  
Diabetes Mellitus ◽  
Diabetic Foot ◽  
Serum Magnesium ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Magnesium Level ◽  
Serum Magnesium Level ◽  
Cross Sectional ◽  
History Of

Objectives: To determine the frequency of hypomagnesemia in patients withdiabetic foot ulcer. Study Design: Cross sectional descriptive nature. Setting: Liaquat UniversityHospital Jamshoro / Hyderabad. Period: 29-09-2016 to 28-03-2017. Patients and Methods:The patients with history of diabetes mellitus (known cases) for more than 3 years durationhad diabetic foot ulcer for ≥ 02 weeks duration, of 30-60 years of age & either gender wererecruited and evaluated for serum magnesium level while the data was analyzed in SPSS 16.Results: Total 100 patients with diabetic foot ulcer were evaluated for hypomagnesaemia. Themean age ±SD of age (years), duration of diabetes (years) and foot ulcer (weeks), BMI (kg/m2),hypertension (systolic and diastolic mmHg), HBA1C and magnesium for whole population was52.86±6.87, 6.95±1.85 and 5.86±2.31, 31.92±2/43, 150.38±10.52 and 95.97±5.97, 9.96±2.73and 1.16±0.95 respectively. Out of one hundred, 55% were males and 45% were females. Thehypertension, smoking, dyslipidemia, obesity, raised HBA1C and hypomagnesemia was foundin 65%, 59%, 59%, 55%, 56% and 67%. Conclusion: Hypomagnesemia detected in subjectswith type 2 diabetes mellitus having foot ulcers.

scholarly journals Perilaku self-management dengan kejadian ulkus diabetikum pada pasien diabetes mellitus tipe 2

2020 ◽  
Vol 14 (3) ◽  
pp. 391-400
Author(s):  
Eka Yudha Chrisanto ◽  
Agustama Agustama
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Diabetic Foot ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Self Management ◽  
Diabetes Diet ◽  
Diabetes Melitus

Self-management behaviour of diabetic foot ulcer occurrence among patient with  type 2 diabetes mellitusBackground: Diabetes mellitus is one of the silent killers. Indonesia is a country with the 4th largest number of people with diabetes mellitus after China, India, and the United States. In Indonesia people with diabetes mellitus increased from 8.4 million in 2000 to 21.3 million in 2030.Purpose: To determine the self-management behaviour and diabetic foot ulcer occurrence among patient with  type 2 diabetes mellitus.Method: A quantitative research type, with cross sectional analytic and analytical research designs. The population of all people with diabetes mellitus as many as 432 people and a sample of 38 people with a total sampling technique. Data collection using questionnaire sheets and statistical tests used were Chi-Square statistical tests.Results: The frequency distribution of the incidence of diabetic ulcers in patients with type 2 diabetes mellitus, with the category of diabetic ulcers occurring as many as 14 respondents (36.8%). Diabetes diet adherence in patients with diabetes mellitus, with the category of non-compliance with 16 respondents (42.1%). Monitoring blood sugar levels in patients with type 2 diabetes mellitus, with non-routine categories of 15 respondents (39.5%). Physical activity in patients with type 2 diabetes mellitus, with a less good category of 19 respondents (50%).Conclusion: There is a relationship between blood sugar and diabetic ulcer diabetes in type 2 diabetes mellitus patients. There is a relationship between diabetes diet and diabetic ulcer diabetes in type 2 diabetes mellitus patients. There is a relationship between physical activity and the incidence of diabetic ulcers in patients with type 2 diabetes mellitus. It is expected that DM patients can routinely carry out physical and routine activities with high salt levels) in health care facilities and carry out a diabetes diet in accordance with the rules proposed by nutritionists.Keywords: Self-management; Behaviour; Diabetic foot ulcer; Occurrence; Patient; Type 2 diabetes mellitusPendahuluan: Diabetes melitus salah satu the silent killer. Indonesia merupakan negara dengan jumlah penderita diabetes melitus ke-4 terbanyak setelah Cina, India, dan Amerika Serikat.di Indonesia penyandang diabetes melitus mengalami kenaikan dari 8,4 juta pada tahun 2000 menjadi 21,3 juta pada tahun 2030.Tujuan: Diketahui hubungan perilaku self-management dengan kejadian ulkus diabetikum pada pasien diabetes mellitus tipe 2Metode: Jenis penelitian kuantitatif, dengan rancangan penelitian analitik dan pendekatan cross sectional. Populasi seluruh seluruh penderita diabetes melitus sebanyak 432 orang dan sampel sebanyak 38 orang dengan teknik total Sampling. Pengumpulan data menggunakan lembar kuesioner dan Uji statistik yang digunakan adalah uji statistik Chi-Square.Hasil: Distribusi frekuensi kejadian ulkus diabetikum pada penderita diabetes melitus tipe 2, dengan kategori terjadi ulkus diabetikum sebanyak 14 responden (36,8%). Kepatuhan diet diabetes pada pasien diabetes melitus, dengan kategori tidak patuh sebanyak 16 responden (42,1%). Pemantauan kadar gula darah pada pasien diabetes melitus tipe 2, dengan kategori tidak rutin sebanyak 15 responden (39,5%). Aktivitas fisik pada pasien diabetes melitus tipe 2, dengan kategori kurang baik sebanyak 19 responden (50%).Simpulan: Ada hubungan pemantauan kadar gula darah dengan kejadian ulkus diabetikum pada pasien diabetes melitus tipe 2. Ada hubungan kepatuhan diet diabetes dengan kejadian ulkus diabetikum pada pasien diabetes melitus tipe 2. Ada hubungan aktivitas fisik dengan kejadian ulkus diabetikum pada pasien diabetes melitus tipe 2. Diharapkan pasien DM agar rutin melakukan aktivitas fisik  serta rutin mengontrol kadar gula darah pada fasilitas pelayanan kesehatan Serta menjalankan diet diabetes sesuai dengan aturan yang disarankan ahli gizi.

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