scholarly journals Importance of CSF lactate concentration in the diagnosis of acute bacterial meningitis

2018 ◽  
Vol 18 (4) ◽  
pp. 351.3-351
Author(s):  
Eamon P McCarron ◽  
Shiva Sreenivasan
Keyword(s):  
Bacterial Meningitis ◽  
Lactate Concentration ◽  
Acute Bacterial Meningitis ◽  
Csf Lactate

scholarly journals Comparison of cerebrospinal fluid lactate with physical, cytological, and other biochemical characteristics as prognostic factors in acute bacterial meningitis

2019 ◽  
Vol 77 (12) ◽  
pp. 871-880
Author(s):  
Sérgio Monteiro De Almeida ◽  
Nagyla C. Barros ◽  
Ricardo Petterle ◽  
Keite Nogueira
Keyword(s):  
Cerebrospinal Fluid ◽  
Bacterial Meningitis ◽  
Lactate Concentration ◽  
Good Prognosis ◽  
Acute Bacterial Meningitis ◽  
Csf Biomarkers ◽  
High Morbidity ◽  
Initial Hypothesis ◽  
Csf Lactate ◽  
Lactate Levels

ABSTRACT Bacterial meningitis (BM) is associated with a high morbidity and mortality. Cerebrospinal fluid (CSF) lactate may be used as a prognostic marker of this condition. We hypothesized that CSF lactate levels would remain elevated in participants who died of acute BM compared with those who recovered from this disease. Objective: To evaluate the potential use of lactate and other CSF biomarkers as prognostic markers of acute BM outcome. Methods: This retrospective, longitudinal study evaluated dynamic CSF biomarkers in 223 CSF samples from 49 patients who fulfilled the inclusion criteria of acute BM, with bacteria identified by CSF culturing. The participants were grouped according to outcome: death (n = 9; 18.37%) and survival (n = 40; 81.63%). All participants received appropriate antibiotic treatment. Results: In the logistic regression model, lactate concentration in the final CSF sample, xanthochromia, and CSF glucose variation between the first and last CSF samples were predictors of a poor outcome (death). In contrast, decrease in CSF white blood cell count and CSF percentage of neutrophils, increase in the percentage of lymphocytes, and normalization of the CSF lactate concentration in the last CSF sample were predictors of a good prognosis. Conclusion: The study confirmed the initial hypothesis. The longitudinal analysis of CSF lactate is an important predictor of prognosis in acute BM.

scholarly journals Diagnostic accuracy of cerebrospinal fluid lactate in confirmed cases of acute bacterial meningitis in children

2020 ◽  
Vol 36 (7) ◽  
Author(s):  
Hina Nasir ◽  
Muhammad Faheem Afzal ◽  
Muhammad Haroon Hamid ◽  
Akmal Laeeq
Keyword(s):  
Cerebrospinal Fluid ◽  
Bacterial Meningitis ◽  
Diagnostic Accuracy ◽  
Negative Predictive Value ◽  
Predictive Value ◽  
Lactate Level ◽  
Acute Bacterial Meningitis ◽  
Csf Lactate ◽  
Meningitis In Children ◽  
Sensitivity Specificity

Objective: To determine the diagnostic accuracy of cerebrospinal fluid lactate level in confirmed cases of acute bacterial meningitis in children Methods: This cross sectional study was conducted in the Department of Paediatrics, King Edward Medical University/ Mayo Hospital, Lahore from January to December 2018. A total of 250 children, between two months - 12 years of age, of both the genders, with suspected acute bacterial meningitis were included by non-probability consecutive sampling. Each child was subjected to lumbar puncture for biochemistry, cytology, culture, and lactate level. CSF lactate level of 1.1-2.4 mmol/L was taken as normal, and >2.4 mmol/L was taken as cut off for acute bacterial meningitis. All collected data was entered and analyzed in SPSS version 22. A 2 x 2 table was made to calculate diagnostic accuracy, sensitivity, specificity, positive and negative predictive value for CSF Lactate. Results: The sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy of CSF lactate taking CSF culture as gold standard was 100%, 60.61%, 17.27%, 100% and 63.6% respectively, with kappa of 0.19 and p value of 0.000. Conclusion: At a cut off value of 2.4 mmol/L, cerebrospinal fluid lactate level has a high diagnostic accuracy for acute bacterial meningitis. doi: https://doi.org/10.12669/pjms.36.7.1682 How to cite this:Nasir H Afzal MF, Hamid MH, Laeeq A. Diagnostic accuracy of cerebrospinal fluid lactate in confirmed cases of acute bacterial meningitis in children. Pak J Med Sci. 2020;36(7):---------. doi: https://doi.org/10.12669/pjms.36.7.1682 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals CSF lactate for accurate diagnosis of community-acquired bacterial meningitis

2015 ◽  
Vol 34 (10) ◽  
pp. 2049-2055 ◽  
Author(s):  
S. Giulieri ◽  
C. Chapuis-Taillard ◽  
K. Jaton ◽  
A. Cometta ◽  
C. Chuard ◽  
...  
Keyword(s):  
Bacterial Meningitis ◽  
Accurate Diagnosis ◽  
Csf Lactate

scholarly journals A putative role for homocysteine in the pathophysiology of acute bacterial meningitis in children

2014 ◽  
Vol 14 (1) ◽  
Author(s):  
Roney Santos Coimbra ◽  
Bruno Frederico Aguilar Calegare ◽  
Talitah Michel Sanchez Candiani ◽  
Vânia D’Almeida
Keyword(s):  
Bacterial Meningitis ◽  
Acute Bacterial Meningitis ◽  
Putative Role ◽  
Meningitis In Children

ACUTE BACTERIAL MENINGITIS IN CHILDREN

PEDIATRICS ◽  
1960 ◽  
Vol 25 (5) ◽  
pp. 742-747
Author(s):  
Robert J. Haggerty ◽  
Mohsen Ziai
Keyword(s):  
Clinical Study ◽  
Bacterial Meningitis ◽  
Etiologic Agent ◽  
Acute Bacterial Meningitis ◽  
Controlled Study ◽  
Antimicrobial Drugs ◽  
Significant Difference ◽  
Meningitis In Children ◽  
Multiple Drugs

A controlled study of the treatment of bacterial meningitis with single and multiple, potentially antagonistic antimicrobial drugs was undertaken. Sixty-five patients received a single and 71 received several drugs in combination. The two groups were generally comparable. There was no significant difference in the results: that is antagonism could not be demonstrated in this clinical study. It seems reasonable to recommend that, in patients over 1 month of age with acute primary bacterial meningitis in whom an etiologic agent cannot be promptly identified, the use of multiple drugs aimed at the three most likely organisms (pneumococcus, meningococcus, H. influenzae) can be employed without danger of clinically apparent antagonism.

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