Clinical Evaluation of Hepatocarcinogenesis and Outcome Using a Novel Glycobiomarker <i>Wisteria floribunda</i> Agglutinin-Positive Mac-2 Binding Protein (WFA<sup>+</sup>-M2BP) in Chronic Hepatitis C with Advanced Fibrosis

Background: A test to narrow down patients who require esophagogastroduodenoscopy (EGD) with a high probability of having gastroesophageal varices (GEV) and a high-risk of liver-related events is an unmet need. Methods: The measurement of serum fibrosis markers and EGD was performed in 166 consecutive chronic hepatitis C patients. The correlation between the grades of GEV and fibrosis markers and the subsequent occurrence of liver-related and fibrosis markers were examined. Results: Wisteria floribunda agglutinin-positive human Mac-2 binding protein (WFA+–M2BP) levels increased according to the grade of GEV (3.4 (0.2–18.6) for no GEV, 7.9 (1.8–20.0) for small GEV, and 11.4 (4.0–20.0) for large GEV; p < 0.001). The diagnostic accuracy of the WFA+–M2BP was superior compared to other serum fibrosis markers, and WFA+–M2BP was an independent predictor of GEV in the multivariate analysis. Furthermore, the cumulative incidence of liver-related events at one year was 2.3% in patients with WFA+–M2BP levels ≤ 7.0 and 37.5% in patients with WFA+–M2BP levels > 7.0 (p < 0.001). WFA+–M2BP > 7.0 was a significant predictive factor for liver-related events (Hazard ratio 6.7, p = 0.004) independent of Child–Pughclass. Conclusions: WFA+–M2BP could be used to estimate the presence and grade of GEV and is linked to liver-related events in chronic hepatitis C patients.

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The role of serum Wisteria floribunda agglutinin-positive Mac-2 binding protein in the assessment of fibrosis in children with chronic hepatitis C

10.21203/rs.3.rs-1087597/v1 ◽

2021 ◽

Author(s):

Hitoshi Tajiri ◽

Mitsuyoshi Suzuki ◽

Kazuhiko Bessho ◽

Yoshinori Ito ◽

Jun Murakami ◽

...

Keyword(s):

Chronic Hepatitis ◽

Hepatitis C ◽

Chronic Hepatitis C ◽

Binding Protein ◽

Characteristic Curve ◽

Area Under The Curve ◽

Post Treatment ◽

Control Group ◽

New Findings ◽

Wisteria Floribunda

Abstract BackgroundAt present non-invasive fibrosis markers are not available for assessment of liver fibrosis in children with chronic hepatitis C. MethodsSixty-three children with chronic hepatitis C were included. Changes in Wisteria floribunda agglutinin-positive Mac-2 binding protein (M2BPGi) levels were evaluated in l3 of 27 treatment-naive patients during the observation period of the natural course of disease (median 4, range 3-6 years). Changes during treatment were evaluated in 27 of 36 patients for 4 (2-9) years of post-treatment follow-up. ResultsThere were significant differences in the levels of M2BPGi between the control group and HCV F0 group (P=0.002) and between the control group and HCV F1 group (P<0.001). Receiver operating characteristic curve analysis showed that to detect stage F1 fibrosis cut off value was 0.95 for M2BPGi with sensitivity 52%, specificity 90%, and area under the curve 0.687. A substantial decrease in M2BPGi levels by treatment was shown from 0.98±0.57 at pre-treatment to 0.42±0.15 at post-treatment (P<0.001) in the 27 treated-patients. ConclusionsOur study shows new findings that M2BPGi may be useful to predict the presence of a mild degree of fibrosis in children with chronic hepatitis C and such a mild fibrosis may be quickly resolved by antiviral therapies.

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SAT-268-Non-invasive prediction of gastroesophageal varies by serum wisteria floribunda agglutinin positive Mac-2 binding protein and FIB-4 index in chronic hepatitis C

Journal of Hepatology ◽

10.1016/s0618-8278(19)31501-4 ◽

2019 ◽

Vol 70 (1) ◽

pp. e751-e753

Author(s):

Keiya Watakabe ◽

Nobuharu Tamaki ◽

Sakura Kirino ◽

Leona Osawa ◽

Wang Wan ◽

...

Keyword(s):

Chronic Hepatitis ◽

Hepatitis C ◽

Chronic Hepatitis C ◽

Binding Protein ◽

Non Invasive ◽

Wisteria Floribunda

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Chronic Hepatitis C: An Overview of Evidence on Epidemiology and Management from a Brazilian Perspective

International Journal of Hepatology ◽

10.1155/2015/852968 ◽

2015 ◽

Vol 2015 ◽

pp. 1-10 ◽

Cited By ~ 5

Author(s):

Rodolfo Castro ◽

Hugo Perazzo ◽

Beatriz Grinsztejn ◽

Valdilea G. Veloso ◽

Chris Hyde

Keyword(s):

Public Health ◽

Chronic Hepatitis ◽

Hepatitis C ◽

Chronic Hepatitis C ◽

Public Health Issue ◽

Advanced Fibrosis ◽

Noninvasive Methods ◽

Treatment Protocols ◽

Major Public Health Issue ◽

Effectiveness Analysis

Chronic hepatitis C remains one of the main causes of chronic liver disease worldwide and presents a variable natural history ranging from minimal changes to advanced fibrosis and cirrhosis and its complications, such as development of hepatocellular carcinoma. Approximately, 1.45 million people are estimated to be infected by HCV in Brazil representing a major public health issue. The aim of this paper was to review the epidemiology and management of chronic hepatitis C from a Brazilian perspective. The management of chronic hepatitis C has been challenged by the use of noninvasive methods to stage liver fibrosis as an alternative to liver biopsy and the high cost of new interferon-free antiviral treatments. Moreover, the need of cost-effectiveness analysis in hepatitis C and the recent changes in treatment protocols were discussed.

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