scholarly journals No Potential Role of Genetic Polymorphisms for IL-4, IL-13 and IL-4 Receptor in Respiratory Allergy : A Study in Adults Working at Social Welfare Facilities in Korea

2006 ◽  
Vol 28 (4) ◽  
pp. 369-379 ◽  
Author(s):  
Hyoung Ah KIM ◽  
Young Jeu HEO ◽  
Seung Hye LEE ◽  
Sang Hoon KIM ◽  
Yong HEO
Keyword(s):  
Social Welfare ◽  
Genetic Polymorphisms ◽  
Potential Role ◽  
Respiratory Allergy

Role of polymorphism of the interleukin-1B gene and other genetic polymorphisms in the aetiology of root resorption in patients receiving orthodontic treatment

2017 ◽  
Vol 13 (1) ◽  
pp. 36-42
Author(s):  
Marzena Makowska-Kaczmarska ◽  
Anna Okoń ◽  
Elżbieta Olszewska
Keyword(s):  
Genetic Polymorphisms ◽  
Gene Polymorphisms ◽  
Orthodontic Treatment ◽  
Potential Role ◽  
Root Resorption ◽  
Interleukin 1 ◽  
Dna Testing ◽  
Individual Gene ◽  
Global Population

Aim. The aim of the work was to present the latest directions in the research on gene polymorphisms in the global population and to discuss their potential role in the pathogenesis of root resorption during orthodontic treatment. Material and methods. A review of the literature in Polish and English from the years 1990–2015 was conducted using PubMed/MEDLINE databases and the results of studies kept in the database of the National Centre for Biotechnology Information were used. Key words used: genetics of root resorption, genetic polymorphism, interleukin-1B. Results. 19 articles were analysed. Special attention was placed on the latest studies on the human genome, especially focused on gene polymorphisms in the global population. Summary. Pathogenesis of root resorption during orthodontic treatment is complex. Its background is undoubtedly genetic. Gene polymorphism is important. The role of polymorphism of the interleukin-1B gene and other genes in the interleukin-1 cluster draws special attention. Identification of genetic factors that play an important role in the aetiology of root resorption may in the future help to identify patients susceptible to such complications even before the beginning of orthodontic treatment. Potential possibilities of DNA testing in clinical practice are enormous. The role of individual gene polymorphisms in the pathogenesis of root resorption has not been yet explained in detail and further multicentre studies are necessary. At this stage of studies no reliable markers have been detected in order to predict which patients would develop this complication. (Makowska- Kaczmarska M, Okoń A, Olszewska E. Role of polymorphism of the interleukin-1B gene and other genetic polymorphisms in the aetiology of root resorption in patients receiving orthodontic treatment. Orthod Forum 2017; 13: 36-42).

scholarly journals An Overview of Registered Clinical Trials on Glucosinolates and Human Health: The Current Situation

2021 ◽  
Vol 8 ◽  
Author(s):  
Mirko Marino ◽  
Daniela Martini ◽  
Samuele Venturi ◽  
Massimiliano Tucci ◽  
Marisa Porrini ◽  
...  
Keyword(s):  
Human Health ◽  
Genetic Polymorphisms ◽  
Potential Role ◽  
Controlled Trial ◽  
Epidemiological Studies ◽  
Randomized Controlled ◽  
Current Review ◽  
Pure Compounds ◽  
Emerging Topics

Epidemiological studies suggest a potential role of glucosinolates (GSLs) and isothiocyanates on human health. However, evidence from intervention studies, due to heterogeneity in features of study design, duration, participants, food or food components administered, and outcomes analyzed, is still insufficient. The current review aims to provide an overview of the trials on GSLs and GSL-rich foods registered over the last 20 years with the intention to summarize the main topics and results, but also the existing gaps that still need to be covered. Studies were collected by using ClinicalTrials.gov and the International Standard Randomized Controlled Trial Number (ISRCTN) registry. A total of 87 registered trials were identified with which most of them were performed by using extracts or pure compounds (n = 60) while few were conducted with GSL-rich foods (n = 27). In detail, sulforaphane was the most investigated compound, while broccoli was the most frequent food tested in the trials. The majority of the studies assessed the health effects of GSLs focusing on outcomes related to cancer and cognitive function, even if the current findings are not univocal. Emerging topics also included the study of GSLs and gut microbiota interaction and impact on skin health. Further attention was also drawn to the bioavailability of GSLs and/or derivatives from foods, extracts, and single compounds by also considering the contribution of the different genetic polymorphisms. In conclusion, although considerable efforts have been made to study GSLs and GSL-rich foods, further studies are necessary to provide evidence-based research and to corroborate the findings obtained. The interindividual response due to genetic polymorphisms should be further investigated in order to explore the contribution to the overall beneficial effect.

POPDC proteins and cardiac function

2019 ◽  
Vol 47 (5) ◽  
pp. 1393-1404 ◽  
Author(s):  
Thomas Brand
Keyword(s):  
Potential Role ◽  
Striated Muscle ◽  
Short Review ◽  
Effector Proteins ◽  
Muscle Disease ◽  
Disease Genes ◽  
Protein Protein Interaction ◽  
Interaction Partners ◽  
And Function

Abstract The Popeye domain-containing gene family encodes a novel class of cAMP effector proteins in striated muscle tissue. In this short review, we first introduce the protein family and discuss their structure and function with an emphasis on their role in cyclic AMP signalling. Another focus of this review is the recently discovered role of POPDC genes as striated muscle disease genes, which have been associated with cardiac arrhythmia and muscular dystrophy. The pathological phenotypes observed in patients will be compared with phenotypes present in null and knockin mutations in zebrafish and mouse. A number of protein–protein interaction partners have been discovered and the potential role of POPDC proteins to control the subcellular localization and function of these interacting proteins will be discussed. Finally, we outline several areas, where research is urgently needed.

The Effect of Path Length and Display Size on Memory for Spatial Information

2012 ◽  
Vol 59 (3) ◽  
pp. 147-152 ◽  
Author(s):  
Katherine Guérard ◽  
Sébastien Tremblay
Keyword(s):  
Path Length ◽  
Potential Role ◽  
Spatial Information ◽  
Recall Performance ◽  
Minor Role ◽  
Length Effect ◽  
Serial Memory ◽  
Fixed Reference ◽  
A Minor

In serial memory for spatial information, some studies showed that recall performance suffers when the distance between successive locations increases relatively to the size of the display in which they are presented (the path length effect; e.g., Parmentier et al., 2005) but not when distance is increased by enlarging the size of the display (e.g., Smyth & Scholey, 1994). In the present study, we examined the effect of varying the absolute and relative distance between to-be-remembered items on memory for spatial information. We manipulated path length using small (15″) and large (64″) screens within the same design. In two experiments, we showed that distance was disruptive mainly when it is varied relatively to a fixed reference frame, though increasing the size of the display also had a small deleterious effect on recall. The insertion of a retention interval did not influence these effects, suggesting that rehearsal plays a minor role in mediating the effects of distance on serial spatial memory. We discuss the potential role of perceptual organization in light of the pattern of results.

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