scholarly journals Synthesis, Chracterization and Antibacterial Activity of Cd(II) and Zr(IV) Peroxo-complexes

2020 ◽  
pp. 22-28
Author(s):  
Md. Mahasin Ali ◽  
Md. Nur Amin Bitu ◽  
Md. Saddam Hossain ◽  
Md. Faruk Hossen ◽  
Md. Ali Asraf ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Schiff Base ◽  
Schiff Base Ligand ◽  
Metal Ion ◽  
Pathogenic Bacteria ◽  
Shigella Dysenteriae ◽  
Hydroxyl Group ◽  
Spectral Studies ◽  
Peroxo Complexes ◽  
Ft Ir

Two new peroxo-complexes of Cd(II) and Zr(IV) ion containing Schiff base (SB) were synthesized and characterized by Thin Layer Chromatography (TLC), Elemental analyses, conductivity, magnetic moment measurements, UV-Vis. and FT-IR spectral studies. The Schiff base ligand derived from cinnamaldehyde and o-aminophenol participated in complexation through a single pot reaction. FT-IR spectra showed that the Schiff base ligand coordinated to the metal ion through nitrogen of azomethine group and oxygen of hydroxyl group & peroxo group (O-O). The molar conductance values indicated the non-electrolytic nature of both the complexes. Antibacterial activity of the complexes was tested against four pathogenic bacteria, two Gram-positive Staphylococcus aureus & Bacillus cereus and two Gram-negative Escherichia coli & Shigella dysenteriae with standard Kanamycin-30. The result showed that Cd(II) complex exhibited more potential antibacterial activity than the Zr(IV) complex against all the tested pathogens.

scholarly journals One Pot Synthesis of Cu(II) and Ni(II) Peroxo Complexes Containing Schiff Base: Physicochemical, Spectral and Antibacterial Investigations

2020 ◽  
pp. 15-21
Author(s):  
Md. Mahasin Ali ◽  
Md. Nur Amin Bitu ◽  
Md. Saddam Hossain ◽  
Md. Faruk Hossen ◽  
Md. Ali Asraf ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Schiff Base ◽  
Schiff Base Ligand ◽  
Magnetic Moment ◽  
Pathogenic Bacteria ◽  
Shigella Dysenteriae ◽  
Hydroxyl Group ◽  
Spectral Studies ◽  
Planar Geometry ◽  
Peroxo Complexes

Two new peroxo complexes of Cu(II) and Ni(II) ion containing Schiff base (SB) were synthesized and characterized by TLC, Elemental analyses, conductivity, magnetic moment measurements, UV-Vis. and IR and ESI-MS spectral studies. The Schiff base ligand derived from cinnamaldehyde and o-aminophenol participated in complexation through a single pot reaction. IR spectra showed that the Schiff base ligand coordinated to the metal ion through nitrogen of azomethine group and oxygen of hydroxyl group & peroxo group (O-O). Magnetic moment value coupled with electronic spectral data suggested a square planar geometry for both the complexes. The molar conductance values indicated the non-electrolytic nature of the complexes. Antibacterial activity of the complexes was tested against four pathogenic bacteria, two Gram-positive Staphylococcus aureus & Bacillus cereus and two Gram-negative Escherichia coli & Shigella dysenteriae with Kanamycin (K-30) standard. The result shows that Cu(II) complex exhibited more potential antibacterial activity than the Ni(II) complex against all the tested organisms.

scholarly journals Comparative Studies on Synthesis, Characterization and Antibacterial Properties between Schiff Base Co(II) Complex and Peroxo Complex

2020 ◽  
pp. 1-7
Author(s):  
Md. Mahasin Ali ◽  
Md. Nur Amin Bitu ◽  
Md. Saddam Hossain ◽  
Md. Faruk Hossen ◽  
Md. Ali Asraf ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Schiff Base ◽  
Metal Ion ◽  
Pathogenic Bacteria ◽  
Antibacterial Properties ◽  
Molar Conductance ◽  
Shigella Dysenteriae ◽  
Spectral Studies ◽  
Peroxo Complex ◽  
Azomethine Group

A new Schiff base Co(II) complex and - peroxo complex were synthesized and characterized by thin layer chromatography (TLC), elemental analyses, magnetic moment, conductivity measurements, UV-Vis., IR and ESI-MS spectral studies. The cobalt ion was participated in direct complexation with the Schiff base (SB) ligand derived from o-aminobenzoic acid and cinnamaldehyde during the single pot reaction. IR spectral data showed that the Schiff base ligand coordinated to the metal ion through nitrogen of azomethine group and oxygen of carboxyl group (COO-). The molar conductance values indicated that both the complexes are non-electrolytic in nature. Antibacterial activity of the complexes was tested against four pathogenic bacteria namely Staphylococcus aureus, Bacillus cereus, Escherichia coli & Shigella dysenteriae with standard Kanamycin-30. The results showed that both type of complexes have moderate to strong antibacterial activity and the peroxo complex is relatively more potential towards all the tested organisms.

scholarly journals Synthesis, Characterization, Antimicrobial and Anticancer Activity of New Bidentate Schiff Base Ligand and their Transition Metal(II) Complexes

2021 ◽  
Vol 33 (7) ◽  
pp. 1488-1494
Author(s):  
S. Arulmozhi ◽  
G. Sasikumar ◽  
A. Subramani ◽  
A. Sudha ◽  
S.J. Askar Ali
Keyword(s):  
Schiff Base ◽  
Anticancer Activity ◽  
Cell Lines ◽  
Schiff Base Ligand ◽  
Pathogenic Bacteria ◽  
Human Tumor ◽  
Spectral Studies ◽  
Breast Adenocarcinoma ◽  
Human Colon Cancer

The metal(II) complexes were synthesized by addition of corresponding MCl2 (M = Mn2+, Ni2+, Cu2+ and Zn2+) with 1,2-bis(1H-pyrrol-2-ylmethylene)diazane in methanol. The ligand acts as a bidentate as confirmed from the mass, IR, UV, NMR and EPR spectral studies. The Schiff base ligand forms hexa-coordinated complexes having octahedral geometry for Mn(II), Ni(II), Zn(II) and Cu(II) complexes. The metal complexes showed an excellent antimicrobial activity spectrum in vitro against both Gram-negative (Klebsiella pneumoniae and Acinetobacter baumannii), Gram-positive (Staphylococcus aureus and Enterococcus faecalis) and human pathogenic bacteria isolates. To find the binding affinity with protein BSA kinase, for that molecular docking studies were also carried for all the four synthesized metal(II) complexes. The anticancer activity of the synthesized metal(II) complexes was also screened against the three human tumor cell lines MCF7 human breast adenocarcinoma cell line, CaSki human caucasian cervical epidermoid carcinoma and HCT116 human colon cancer cell lines. The present study showed that Zn(II) complex showed potent inhibition by the ratio of 80% as compared to the inhibition in the normal cells (L-6).

scholarly journals Synthesis, Characterization and Antibacterial Activity of Schiff Base, 4-Chloro-2-{(E)-[(4-Fluorophenyl)imino]methyl}phenol Metal (II) Complexes

2020 ◽  
Vol 2020 ◽  
pp. 1-8 ◽  
Author(s):  
F. K. Ommenya ◽  
E. A. Nyawade ◽  
D. M. Andala ◽  
J. Kinyua
Keyword(s):  
Antibacterial Activity ◽  
Schiff Base ◽  
Metal Complexes ◽  
Elemental Analysis ◽  
Schiff Base Ligand ◽  
Condensation Reaction ◽  
Molar Conductance ◽  
Diffusion Method ◽  
Elemental Analysis Data ◽  
Ft Ir

A new series of Mn (II), Co (II), Ni (II), Cu (II), and Zn (II) complexes of the Schiff base ligand, 4-chloro-2-{(E)-[(4-fluorophenyl)imino]methyl}phenol (C13H9ClFNO), was synthesized in a methanolic medium. The Schiff base was derived from the condensation reaction of 5-chlorosalicylaldehyde and 4-fluoroaniline at room temperature. Elemental analysis, FT-IR, UV-Vis, and NMR spectral data, molar conductance measurements, and melting points were used to characterize the Schiff base and the metal complexes. From the elemental analysis data, the metal complexes formed had the general formulae [M(L)2(H2O)2], where L = Schiff base ligand (C13H9ClFNO) and M = Mn, Co, Ni, Cu, and Zn. On the basis of FT-IR, electronic spectra, and NMR data, “O” and “N” donor atoms of the Schiff base ligand participated in coordination with the metal (II) ions, and thus, a six coordinated octahedral geometry for all these complexes was proposed. Molar conductance studies on the complexes indicated they were nonelectrolytic in nature. The Schiff base ligand and its metal (II) complexes were tested in vitro to evaluate their bactericidal activity against Gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa) and Gram-positive bacteria (Bacillus subtilis and Staphylococcus typhi) using the disc diffusion method. The antibacterial evaluation results revealed that the metal (II) complexes exhibited higher antibacterial activity than the free Schiff base ligand.

scholarly journals SYNTHESIS, CHARACTERISATION, THERMAL ANALYSIS AND DNA CLEAVAGE ACTIVITY OF A NOVELZINC (II) COMPLEX OF PYRAZOLE SCHIFF BASES

2018 ◽  
Vol 5 (2) ◽  
pp. 19-23
Author(s):  
Jayanthi Eswaran
Keyword(s):  
Schiff Base ◽  
Schiff Base Ligand ◽  
Dna Cleavage ◽  
Metal Ion ◽  
Acid Hydrazide ◽  
Single Step ◽  
Cleavage Activity ◽  
Dna Cleavage Activity ◽  
Shiff Base ◽  
Ft Ir

A hydrazone Schiff base Zn(II) metal complex is synthesised from the Shiff base ligand Thiophene-2-carboxylic acid hydrazide and 1, 3-diphenyl-1H-pyrazole-4-carboxaldehyde reacted together in 1:1 mole ratio to obtain Schiff base ligand (HL) which was subsequently, allowed to react with Zn(CH3COO)2.2H2O. The Schiff base ligand and its Zn (II) complex prepared were characterized on the basis of elemental nalysis,thermogravimetry, UV-Visible spectroscopy, FT-IR spectroscopy and NMR spectroscopy. IR spectrum of the zinc complex shows that the ligand (HL) is coordinated to the metal ion in monoanionicbidentate fashion with the 1:2 metal to ligand stoichiometry. The thermal behaviour of thecomplex shows a single step decomposition pattern leaving the respective ZnO residue. The DNA cleavage activity of the complex ismonitored using agarose gel lectrophoresis method which indicates the potential of the complex to cleave supercoiled DNA.

Spectral and Thermal Investigation of Novel Glycine-Based Schiff Base Derivative and its Metal Complexes

2011 ◽  
Vol 474-476 ◽  
pp. 543-547
Author(s):  
Ti Feng Jiao ◽  
Juan Zhou ◽  
Jing Xin Zhou ◽  
Yuan Yuan Xing ◽  
Xu Hui Li
Keyword(s):  
Thermal Stability ◽  
Schiff Base ◽  
Metal Complexes ◽  
Metal Ion ◽  
Uv Spectra ◽  
Ethanol Solution ◽  
Hydroxyl Group ◽  
Imino Group ◽  
Base Derivative ◽  
Ft Ir

A novel glycine-based Schiff base derivative (abbreviated as C16GlySb) containing long alkyl chain was synthesized from glycine reacted with 4-cetyloxy-2-hydroxybenzaldehyde and sequentially coordinated with various metal ions to give the corresponding metal complexes (abbreviated as G-M). The products were characterized by UV-Vis spectra and FT-IR spectra. At the same time, the thermal stability was measured by TG-DTA instrument. FT-IR analysis indicated that the nitrogen atom in imino group, oxygen atom in phenolic hydroxyl group, and carboxylic ion participated in coordinating with transition metal ion in doubly-bridged mode. UV spectra showed that compared with ethanol solution, the cast film on quartz plate showed H-type or J-type aggregate structure. In addition, the thermal stability of G-M had been obviously superior to that of the ligand C16GlySb. The present results have showed potential application in fields of functional material and catalyst.

scholarly journals Synthesis, Characterization, Biological Activity and DNA Binding Studies of Metal Complexes with 4-Aminoantipyrine Schiff Base Ligand

2012 ◽  
Vol 9 (1) ◽  
pp. 389-400 ◽  
Author(s):  
B. Anupama ◽  
M. Padmaja ◽  
C. Gyana Kumari
Keyword(s):  
Schiff Base ◽  
Transition Metal ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Schiff Base Ligand ◽  
Metal Ion ◽  
Spectral Studies ◽  
Significant Activity ◽  
Central Metal ◽  
Binding Studies

A new series of transition metal complexes of Cu(II),Ni(II),Co(II), Zn(II) and VO(IV) have been synthesized from the Schiff base ligand (L) derived from 4-amino antipyrine and 5- bromo salicylaldehyde. The structural features of Schiff base and metal complexes were determined from their elemental analyses, thermogravimetric studies, magneticsusceptibility, molar conductivity, ESI-Mass, IR, UV-VIS,1H NMR and ESR spectral studies. The data show that the complexes have composition of ML2type. The UV-VIS, magnetic susceptibility and ESR spectral data suggest an octahedral geometry around the central metal ion. Biological screening of the complexes reveals that the Schiff base transition metal complexes show significant activity against microorganisms. Binding of Co(II) complex with calf thymus DNA (CT DNA) was studied by spectral methods.

scholarly journals Structural, Spectroscopic and Biological Aspects of O, N- Donor Schiff Base Ligand and its Cr(III), Co(II), Ni(II) and Cu(II) Complexes Synthesized through Green Chemical Approach

2010 ◽  
Vol 7 (s1) ◽  
pp. S566-S572 ◽  
Author(s):  
Kavita Rathore ◽  
Rajiv K. R. Singh ◽  
H. B. Singh
Keyword(s):  
Schiff Base ◽  
Schiff Base Ligand ◽  
Metal Ion ◽  
Molar Conductance ◽  
Azomethine Nitrogen ◽  
Spectral Studies ◽  
Central Metal ◽  
Bacterial Strains ◽  
Phenolic Oxygen ◽  
Bidentate Schiff Base Ligand

The monofunctional bidentate Schiff base ligand (o-vanillin)p-chloroaniline and its four new complexes of chromium(III), cobalt(II), nickel(II) and copper(II) have been synthesized by classical thermal and microwave-irradiated techniques. All the new derivatives have been characterized by elemental analysis, molecular weight determinations, molar conductance measurements, UV-Vis, IR and NMR spectral studies. The IR spectral data suggest the involvement of phenolic oxygen after deprotonation and azomethine nitrogen in coordination to the central metal ion. The growth inhibiting potential of the ligands and complexes has been assessed against a variety of fungal and bacterial strains.

Research on Some Aromatic Schiff Base Compounds and Metal Complexes with Different Substituted Groups

2011 ◽  
Vol 474-476 ◽  
pp. 1523-1528
Author(s):  
Ti Feng Jiao ◽  
Jian Liu ◽  
Li Hua Gao ◽  
Jing Xin Zhou ◽  
Yuan Yuan Xing
Keyword(s):  
Thermal Stability ◽  
Schiff Base ◽  
Metal Complexes ◽  
Metal Ion ◽  
Uv Spectra ◽  
Hydroxyl Group ◽  
Imino Group ◽  
Schiff Base Derivatives ◽  
Ft Ir ◽  
Ir Analysis

Two aromatic Schiff base derivatives and the corresponding metal complexes with different substituted groups were synthesized and characterized by many methods. The products were characterized by UV-Vis spectra, FT-IR spectra and thermal analysis, while the thermal stability was measured by TG-DTA instrument. FT-IR analysis indicated that the nitrogen atom in imino group and oxygen atom in phenolic hydroxyl group participated in coordinating with transition metal ion in different bridged mode. UV spectra also verified that different coordination modes can be performed between metal ions and ligands. In addition, the thermal stability of metal complexes had been obviously superior to that of the ligands. All results give a useful clue to obtain Schiff base derivatives with versatile property by regulating intramolecular substituted group and species of metal ion. The present results have showed potential application in fields of functional material and catalyst.

scholarly journals Synthesis and DFT Study of the Complexation of Schiff Base Derived Curcumin and L-Tyrosine with Al(III), Ag(I), and Pb(II) Metal Ions

2021 ◽  
Vol 21 (3) ◽  
pp. 708
Author(s):  
Ali Mahmood Ali ◽  
Tagreed Hashim Al-Noor ◽  
Eid Abdalrazaq ◽  
Abdel Aziz Qasem Jbarah
Keyword(s):  
Schiff Base ◽  
Dft Calculations ◽  
13C Nmr ◽  
Schiff Base Ligand ◽  
Metal Ion ◽  
Density Functional ◽  
Vibrational Frequencies ◽  
Basis Set ◽  
Spectral Studies ◽  
Central Metal

The multi-dentate Schiff base ligand (H2L), where H2L=2,2'-(((1,3,5,6)-1-(3-((l1-oxidaneyl)-l5-methyl)-4-hydroxyphenyl)-7-(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-diylidene)bis(azaneylylidene))bis(3-(4-hydroxyphenyl)propanoic acid), has been prepared from curcumin and L- Tyrosine amino acid. The synthesized Schiff base ligand (H2L) and the second ligand 1,10-phenanthroline (phen) are used to prepare the new complexes [Al(L)(phen)]Cl, K[Ag(L)(phen)] and [Pb(L)(phen)]. The synthesized compounds are characterized by magnetic susceptibility measurements, micro elemental analysis (C.H.N), mass spectrometry, molar conductance, FT-infrared, UV-visible, atomic absorption (AA), 13C-NMR, and 1H-NMR spectral studies. The characterization of the synthesized complexes shows that the environment surrounding the central metal ion in the complexes adopted a distorted octahedral configuration. Moreover, the conductivity measurements show a non-electrolytic character for the [Pb(L)(phen)] complex and an electrolytic character for the [Al(L)(phen)]Cl and K[Ag(L)(phen)] complexes. The experimental infrared data are supported by density functional theory (DFT) calculations using the B3LYP level of theory and LANL2DZ basis set. The vibrational frequencies of the molecules are computed using the optimized geometry obtained from the DFT calculations. The calculated vibrational frequencies have been compared with obtained experimental values. 1H and 13C-NMR chemical shifts were computed for the H2L ligand using the DFT/GIAO method. Additionally, the molecular electronic structures of the complexes have been investigated by DFT calculations.

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