Recent Advances Regarding the Phytochemical and Therapeutic Benefits of Diospyros kaki Fruit

Recent Advances on SGLT 2 Inhibitors: Synthetic Approaches, Therapeutic Benefits, and Adverse Events

Successful Drug Discovery ◽

10.1002/9783527826872.ch4 ◽

2021 ◽

pp. 111-157

Author(s):

Ana M. Matos ◽

Patrícia Calado ◽

William Washburn ◽

Amélia P. Rauter

Keyword(s):

Adverse Events ◽

Therapeutic Benefits ◽

Recent Advances ◽

Synthetic Approaches

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Vasopressin–aquaporin-2 pathway: recent advances in understanding water balance disorders

F1000Research ◽

10.12688/f1000research.16654.1 ◽

2019 ◽

Vol 8 ◽

pp. 149 ◽

Cited By ~ 14

Author(s):

Marianna Ranieri ◽

Annarita Di Mise ◽

Grazia Tamma ◽

Giovanna Valenti

Keyword(s):

Water Balance ◽

Collecting Duct ◽

Hormone Secretion ◽

Polycystic Kidney ◽

Balance Disorders ◽

Inappropriate Antidiuretic Hormone Secretion ◽

Aquaporin 2 ◽

Therapeutic Benefits ◽

Recent Advances ◽

Autosomal Dominant Polycystic Kidney

The alteration of water balance and related disorders has emerged as being strictly linked to the state of activation of the vasopressin–aquaporin-2 (vasopressin–AQP2) pathway. The lack of responsiveness of the kidney to the vasopressin action impairs its ability to concentrate the urine, resulting in polyuria, polydipsia, and risk of severe dehydration for patients. Conversely, non-osmotic release of vasopressin is associated with an increase in water permeability in the renal collecting duct, producing water retention and increasing the circulatory blood volume. This review highlights some of the new insights and recent advances in therapeutic intervention targeting the dysfunctions in the vasopressin–AQP2 pathway causing diseases characterized by water balance disorders such as congenital nephrogenic diabetes insipidus, syndrome of inappropriate antidiuretic hormone secretion, nephrogenic syndrome of inappropriate antidiuresis, and autosomal dominant polycystic kidney disease. The recent clinical data suggest that targeting the vasopressin–AQP2 axis can provide therapeutic benefits in patients with water balance disorders.

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Phyto- and Bio-Chemical evaluation of Diospyros kaki L. cultivated in Egypt and its biological activities

Brazilian Journal of Biology ◽

10.1590/1519-6984.200460 ◽

2020 ◽

Vol 80 (2) ◽

pp. 295-304

Author(s):

S. S. El-Hawary ◽

S. H. Tadros ◽

M. M. AbdelMohsen ◽

M. S. Mohamed ◽

E. El Sheikh ◽

...

Keyword(s):

Biological Activities ◽

Radical Scavenging ◽

Water Soluble ◽

Diospyros Kaki ◽

Alcoholic Extract ◽

Good Source ◽

Chemical Evaluation ◽

Therapeutic Benefits ◽

Blood Haemoglobin

Abstract Diospyros kaki L. or Costata cultivar is the main persimmon variety progressively consumed in the Egyptian market and exportation. The objective of this study was to investigate the bioprotective effects of the alcoholic extract of fruits as well as leaves of D. kaki using in-vivo rat models. Petroleum ether extracts of fruits and leaves were analytically characterized for saponifiable and unsaponifiable compounds by GC/MS. Main flavonoids were chromatographically isolated from 80% aqueous methanol extract of leaves. Chemical evaluation for fruits and leaves namely, content of moisture, ash, proteins, fatty acids, amino acids, fat and water soluble vitamins, minerals, carotenoids was carried out. Total antioxidant activity was determined by radical scavenging effects using DPPH assay. The effect on biochemical parameters and its biological activity were also performed. Results revealed the identification of the major compounds of saponifiable and unsaponifiable matters of fruits and leaves. Scopoletin, as well as, kaempferol, luteolin, rutin and apigenin 7-O-glucoside were isolated and identified. It showed that this plant can provide a good nutritional value and it is safe regarding the kidney and liver functions, good source that help in enhancing the antioxidant defense against free radicals. No abnormal effects were found in lipids profile on experimental animals and there were good results in the ratio of HDL and LDL cholesterol. Also, this plant can help in optimizing blood sugar, enhancing the level of blood haemoglobin. It is concluded that D. kaki displays a good source of nutrients and bioactive compounds that may contribute to its therapeutic benefits against the risk of disease complications.

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Recent Advances in High Dispersion Spectroscopy of Globular Cluster Stars

Symposium - International Astronomical Union ◽

10.1017/s0074180900035610 ◽

1988 ◽

Vol 132 ◽

pp. 525-530

Author(s):

Raffaele G. Gratton

Keyword(s):

Globular Cluster ◽

Globular Clusters ◽

High Dispersion ◽

Photographic Material ◽

Recent Advances ◽

Metal Abundances ◽

Ccd Detectors ◽

Major Progress

The use CCD detectors has allowed a major progress in abundance derivations for globular cluster stars in the last years. Abundances deduced from high dispersion spectra now correlates well with other abundance indicators. I discuss some problems concerning the derivation of accurate metal abundances for globular clusters using high dispersion spectra from both the old photographic and the most recent CCD data. The discrepant low abundances found by Cohen (1980), from photographic material for M71 giants, are found to be due to the use of too high microturbulences.

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Chelation-assisted transition metal-catalysed C–H chalcogenylations

Organic Chemistry Frontiers ◽

10.1039/c9qo01497g ◽

2020 ◽

Vol 7 (8) ◽

pp. 1022-1060 ◽

Cited By ~ 7

Author(s):

Wenbo Ma ◽

Nikolaos Kaplaneris ◽

Xinyue Fang ◽

Linghui Gu ◽

Ruhuai Mei ◽

...

Keyword(s):

Transition Metal ◽

Recent Advances ◽

Site Selectivity ◽

Transition Metal Catalyzed ◽

Metal Catalyzed

This review summarizes recent advances in C–S and C–Se formations via transition metal-catalyzed C–H functionalization utilizing directing groups to control the site-selectivity.

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Nucleosome dynamics

Biochemical Society Symposium ◽

10.1042/bss0730109 ◽

2006 ◽

Vol 73 ◽

pp. 109-119 ◽

Cited By ~ 2

Author(s):

Chris Stockdale ◽

Michael Bruno ◽

Helder Ferreira ◽

Elisa Garcia-Wilson ◽

Nicola Wiechens ◽

...

Keyword(s):

High Resolution ◽

Chromatin Structure ◽

Current Knowledge ◽

Dynamic Properties ◽

Structure And Dynamics ◽

Nucleosome Dynamics ◽

Sharp Focus ◽

Recent Advances ◽

Insight Into ◽

Chromatin Structure And Dynamics

In the 30 years since the discovery of the nucleosome, our picture of it has come into sharp focus. The recent high-resolution structures have provided a wealth of insight into the function of the nucleosome, but they are inherently static. Our current knowledge of how nucleosomes can be reconfigured dynamically is at a much earlier stage. Here, recent advances in the understanding of chromatin structure and dynamics are highlighted. The ways in which different modes of nucleosome reconfiguration are likely to influence each other are discussed, and some of the factors likely to regulate the dynamic properties of nucleosomes are considered.

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