Secretor Status and Taste Perception of Phenylthiocarbamide (PTC) are Risk Factors for Pulmonary Tuberculosis

2021 ◽  
pp. 116-123
Author(s):  
C. Igbeneghu ◽  
B. M. Okanlawon ◽  
J. M. Olisekodiaka
Keyword(s):  
Risk Factors ◽  
Pulmonary Tuberculosis ◽  
Taste Perception ◽  
Secretor Status

scholarly journals Risk factors for drug-resistant tuberculosis, the association between comorbidity status and drug-resistant patterns: a retrospective study of previously treated pulmonary tuberculosis in Shandong, China, during 2004–2019

BMJ Open ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. e044349
Author(s):  
Ning-ning Tao ◽  
Yi-fan Li ◽  
Wan-mei Song ◽  
Jin-yue Liu ◽  
Qian-yun Zhang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Drug Resistance ◽  
Retrospective Study ◽  
Pulmonary Tuberculosis ◽  
Logistic Models ◽  
Smoking History ◽  
Categorical Variables ◽  
Drug Resistant ◽  
Drug Resistant Tuberculosis ◽  
Resistant Tuberculosis

ObjectiveThis study was designed to identify the risk factors for drug-resistant tuberculosis (DR-TB) and the association between comorbidity and drug resistance among retreated pulmonary tuberculosis (PTB).DesignA retrospective study was conducted among all the 36 monitoring sites in Shandong, China, over a 16-year period. Baseline characteristics were collected from the TB Surveillance System. Categorical variables were compared by Fisher’s exact or Pearson’s χ2 test. The risk factors for drug resistance were identified using univariable analysis and multivariable logistic models. The influence of comorbidity on different types of drug resistance was evaluated by performing multivariable logistic models with the covariates adjusted by age, sex, body mass index, drinking/smoking history and cavity.ResultsA total of 10 975 patients with PTB were recorded during 2004–2019, and of these 1924 retreated PTB were finally included. Among retreated PTB, 26.2% were DR-TB and 12.5% had comorbidity. Smoking (adjusted OR (aOR): 1.69, 95% CI 1.19 to 2.39), cavity (aOR: 1.55, 95% CI 1.22 to 1.97) and comorbidity (aOR: 1.44, 95% CI 1.02 to 2.02) were risk factors for DR-TB. Of 504 DR-TB, 9.5% had diabetes mellitus, followed by hypertension (2.0%) and chronic obstructive pulmonary disease (1.8%). Patients with retreated PTB with comorbidity were more likely to be older, have more bad habits (smoking, alcohol abuse) and have clinical symptoms (expectoration, haemoptysis, weight loss). Comorbidity was significantly associated with DR-TB (aOR: 1.44, 95% CI 1.02 to 2.02), overall rifampin resistance (aOR: 2.17, 95% CI 1.41 to 3.36), overall streptomycin resistance (aOR: 1.51, 95% CI 1.00 to 2.27) and multidrug resistance (aOR: 1.96, 95% CI 1.17 to 3.27) compared with pan-susceptible patients (p<0.05).ConclusionSmoking, cavity and comorbidity lead to an increased risk of drug resistance among retreated PTB. Strategies to improve the host’s health, including smoking cessation, screening and treatment of comorbidity, might contribute to the control of tuberculosis, especially DR-TB, in China.

Pulmonary tuberculosis: An analysis of isolation practices and clinical risk factors in a tertiary hospital

2019 ◽  
Vol 66 (4) ◽  
pp. 437-442
Author(s):  
Srivathsan Thiruvengadam ◽  
Lauren Giudicatti ◽  
Siaavash Maghami ◽  
Hussein Farah ◽  
Justin Waring ◽  
...  
Keyword(s):  
Risk Factors ◽  
Pulmonary Tuberculosis ◽  
Tertiary Hospital ◽  
Clinical Risk Factors ◽  
Clinical Risk

scholarly journals Risk Factors Related with Mortality in Patient with Pulmonary Tuberculosis

2012 ◽  
Vol 73 (1) ◽  
pp. 38 ◽  
Author(s):  
Chong Whan Kim ◽  
Sang-Ha Kim ◽  
Shun Nyung Lee ◽  
Seok Jeong Lee ◽  
Myoung Kyu Lee ◽  
...  
Keyword(s):  
Risk Factors ◽  
Pulmonary Tuberculosis

scholarly journals Pulmonary Tuberculosis and Delay in Anti-Tuberculous Treatment Are Important Risk Factors for Chronic Obstructive Pulmonary Disease

PLoS ONE ◽  
2012 ◽  
Vol 7 (5) ◽  
pp. e37978 ◽  
Author(s):  
Chih-Hsin Lee ◽  
Ming-Chia Lee ◽  
Hsien-Ho Lin ◽  
Chin-Chung Shu ◽  
Jann-Yuan Wang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Tuberculosis ◽  
Pulmonary Disease ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease
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