scholarly journals Antioxidant Status of Breast, Cervical and Ovarian Cancer Patients at Various Menopausal Stages in Lagos State, Nigeria

2019 ◽  
pp. 1-7
Author(s):  
E. I. Ayo ◽  
M. F. Asaolu ◽  
O. G. Oyebanji ◽  
I. Akinlua ◽  
A. A. Sonuga
Keyword(s):  
Ovarian Cancer ◽  
Cancer Patients ◽  
Teaching Hospital ◽  
Antioxidant Status ◽  
The Body ◽  
University Teaching ◽  
State University ◽  
Control Groups ◽  
Control Subjects ◽  
Lagos State

Cancer is a collection of diseases which involves the abnormal growth of cells with the potential to invade or spread to other parts of the body. The aim of this study is to access the antioxidant status of women with female predominant cancer (breast, cervical and ovarian) in relationship with their menopausal stages. Blood samples were collected from 180 freshly diagnosed female patients of breast, cervical and ovarian cancer at Lagos State University Teaching Hospital, Idi- Araba, Mushin, Lagos and Lagos State University Teaching Hospital Ikeja, Lagos and 60 relatively healthy subjects at different menopausal stages. Serum catalase (CAT), Superoxide dismutase (SOD) activites, Reduced Glutathione (GSH), Vitamin C and E concentrations were evaluated in subject’s blood sample using standard established methods. The results obtained were subjected to statistical analysis (p<0.05). However, the results of the female cancer patients at each menopausal stage were compared to premenopausal, menopausal and postmenopausal control groups, while the results obtained from the menopausal and postmenopausal control subjects were compared to the premenopausal control subjects. There was significant decrease (p<0.05) in the activities of CAT, SOD and in the concentrations of GSH, Vitamins C and E in all the menopausal stages when compared to the control groups. However, MDA concentrations showed significant increase (p<0.05) in all the menopausal stages in comparison to the corresponding control groups. These findings suggest that cancer patients might be at risk from oxidative cell damage. Therefore, further research is required in this field with a view of improving the management of cancers predominant in females.

scholarly journals Level of Adherence to Cytotoxic Drugs by Breast Cancer Patients’ in Lagos State University Teaching Hospital

2015 ◽  
Vol 06 (04) ◽  
pp. 383-389 ◽  
Author(s):  
Popoola Abiodun ◽  
Samira Makanjuola ◽  
Sowunmi Anthonia ◽  
Igwilo Adaeze ◽  
Mobolaji Oludara ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Teaching Hospital ◽  
Cytotoxic Drugs ◽  
University Teaching ◽  
State University ◽  
Breast Cancer Patients ◽  
Lagos State

scholarly journals Morphological spectrum and epidemiological profile of ovarian tumours in black West African women at Lagos state university teaching hospital, Ikeja, Nigeria

2020 ◽  
Vol 8 (6) ◽  
pp. 2067
Author(s):  
Daniel A. Sanni ◽  
Sunday S. Soyemi ◽  
Abiodun O. Popoola ◽  
Kabiru A. Rabiu
Keyword(s):  
Ovarian Cancer ◽  
Germ Cell ◽  
Teaching Hospital ◽  
Germ Cell Tumour ◽  
Ovarian Tumour ◽  
Cell Tumour ◽  
University Teaching ◽  
State University ◽  
Lagos State ◽  
Ovarian Tumours

Background: This study was done to evaluate the histological types, frequency and age distribution of ovarian tumours in Lagos State University Teaching Hospital (LASUTH), Ikeja, Lagos State. This study also aims to classify ovarian tumours in this centre according to the World Health Organisation (WHO).Methods: A retrospective, descriptive hospital study of all ovarian specimens that were sent to the department of pathology and forensic medicine, LASUTH between 1st January, 2011 and 31st December, 2019 was done. Relevant data composed of the age distributions and histopathological types were extracted from the departmental information system and filed documents. The data was analysed using the IBM-SPSS version 25.0.Results: There were 198 cases of ovarian tumours. The mean age at diagnosis of ovarian tumours was 34.6±15.3 years. Unilateral ovarian tumour was observed in 91.9%% of cases while bilateral disease was seen in 8.1%. Primary ovarian tumours constitute 97.0% of all diagnosed tumours of the ovary. Germ cell tumour was the most frequently diagnosed ovarian tumour; and teratoma was the most common, representing 91.2% of germ cell tumours and 47.0% of all ovarian tumours. Primary ovarian cancer peaked at the 6th decade of life and metastatic ovarian cancer was infrequently seen. Serous carcinoma is the most commonly diagnosed ovarian cancer.Conclusions: Ovarian tumour presents most frequently at the 4th decade of life, and germ cell tumour is the most common.

scholarly journals Ferritin and transferrin levels of the elderly population at Lagos State university teaching hospital, Ikeja, Lagos, Nigeria

2021 ◽  
Vol 7 (12) ◽  
pp. 559
Author(s):  
Abdulateef O. Kareem ◽  
Akinsegun A. Akinbami ◽  
Ebele I. Uche ◽  
Aishatu M. Suleiman ◽  
Rafah A. Bamiro ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Serum Ferritin ◽  
Teaching Hospital ◽  
Blood Count ◽  
The Elderly ◽  
University Teaching ◽  
Full Blood Count ◽  
State University ◽  
Lagos State ◽  
The Mean

<p class="abstract"><strong>Background:</strong> The elderly have limited regenerative abilities thus predisposing them to various diseases. Measuring both serum ferritin and transferrin serve as biomarkers of iron deficiency. This study, using enzyme-linked immunosorbent assay (ELISA) determined the serum levels of ferritin and transferrin in the elderly. Full blood count was also done and correlated with serum ferritin and transferrin levels of every participant.</p><p class="abstract"><strong>Methods:</strong> This was a cross-sectional study at the Geriatric Clinic of Lagos State University Teaching Hospital (LASUTH). Following receipt of written consents from ninety (90) elderly participants, venous samples were drawn for full blood count (FBC) and samples for serum ferritin and transferrin ELISA assay collected and stored at -40<sup>o</sup>C until the required sample size was obtained. Data were analyzed using SPSS version 23.0 (Statistical Package for Social Sciences, Inc., Chicago, Ill). The Pearson chi-square test was used for statistical analysis. P value was considered to be statistically significant when &lt;0.05.  </p><p class="abstract"><strong>Results:</strong> Participants consisted of 50 (55.6%) females and 40 (44.4%) males. The mean age of all participants was 71.31±7.38 years. The Majority, 90% (36 of 40) of the males had haemoglobin values lower than 13 gm/dl, while 66% (33 of 50) of females had haemoglobin values lower than 12 gm/dl. The mean ferritin concentration of all participants was 196.19 ±121.21ng/ml. The overall mean serum transferrin was 0.187±0.157 ng/ml with a minimum of 0.03 ng/ml and a maximum of 1.18 ng/ml.</p><p class="abstract"><strong>Conclusions:</strong> Anaemia in the elderly is very common using the World Health Organization (WHO) haemoglobin cut-off values, however, iron deficiency anaemia prevalence is low.</p>

scholarly journals Her-2/neu overexpression in breast cancers in patients of West African extraction seen in Lagos state University Teaching hospital, Nigeria

2019 ◽  
Vol 45 (11) ◽  
pp. 2022-2025
Author(s):  
D.A. Sanni ◽  
A.O. Popoola ◽  
N.A. Ibrahim ◽  
F.O. Omodele ◽  
F.E. Emiogun ◽  
...  
Keyword(s):  
Teaching Hospital ◽  
West African ◽  
University Teaching ◽  
Breast Cancers ◽  
State University ◽  
Lagos State ◽  
Her 2
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