scholarly journals Altered Thyroid Function amongst the Infertile Insulin Resistant Women with Polycystic Ovarian Syndrome

2021 ◽  
pp. 73-80
Author(s):  
Urooj Zafar ◽  
Aliya Irshad Sani ◽  
Hira Ahmed Malik ◽  
Aisha Faraz ◽  
Rabeea Rizwan ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Subclinical Hypothyroidism ◽  
Polycystic Ovarian Syndrome ◽  
Metformin Treatment ◽  
Insulin Resistant ◽  
Child Bearing ◽  
Group B ◽  
Altered Thyroid ◽  
Ovarian Syndrome ◽  
Tsh Levels

Background: Polycystic ovarian syndrome (PCOS) is a hormonal disorder common among women of the child-bearing age. Likewise, women with PCOS are more likely to be obese or overweight, which may be due to their higher Insulin resistance and TSH levels. Aim: The study's objectives were to assess the prevalence of subclinical hypothyroidism in infertile PCOS, distribution of insulin resistant in PCOS women with subclinical hypothyroidism, and the efficacy of Metformin treatment in these women. Methods: It was a single-center study which included all infertile patients who visited the Department of Obstetrics and Gynecology at a Karachi hospital between January 2019 and September 2019. The infertile PCOS patients were then divided into two groups: Group A (Insulin Resistant with Subclinical Hypothyroidism) and Group B. (Non-Insulin Resistant with Subclinical Hypothyroidism). Following the written consent, both the treatment groups received Metformin 500mg T.D. for three months. Results: The infertile PCOS patients showed a higher prevalence of subclinical hypothyroidism. Insulin resistance was found to be 63.3% among subclinical hypothyroid PCOS women. Finally, three months of Metformin treatment resulted in a significant reduction in TSH levels in Insulin resistant PCOS women. Conclusion: We identified a positive link between TSH levels and insulin resistance in PCOS women, both in terms of incidence and treatment.

Effect of Metformin Treatment on Insulin Resistance Markers, and Circulating Irisin in Women with Polycystic Ovarian Syndrome (PCOS)

2019 ◽  
Vol 51 (09) ◽  
pp. 575-579 ◽  
Author(s):  
Asiyeh Masaeli ◽  
Hashem Nayeri ◽  
Mohammadreza Mirzaee
Keyword(s):  
Insulin Resistance ◽  
Polycystic Ovarian Syndrome ◽  
Metabolic Diseases ◽  
Density Lipoprotein ◽  
Adult Women ◽  
Metformin Treatment ◽  
Polycystic Ovaries ◽  
Resistance Markers ◽  
17 Hydroxyprogesterone ◽  
Ovarian Syndrome

AbstractPolycystic ovarian syndrome (PCOS) is considered as a common endocrinal dysfunction among adult women characterized by polycystic ovaries, anovulation, and hyperandrogenism. Irisin is associated with metabolic parameters and insulin resistance. However, the association of irisin with PCOS remains poorly delineated. This study was aimed to examine circulating irisin levels and effects of metformin on this parameter in women with PCOS. Moreover, the association of irisin with insulin resistance markers was determined. Thirty-nine females with PCOS, aged 20–40 years, participated in this study and received 500 mg of metformin once daily for 3 months. Serum creatinine, blood urea nitrogen, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein (LDL), cholesterol, triglyceride, fasting blood sugar, testosterone, 17-hydroxyprogesterone, and irisin were assayed in the studied groups. Circulating irisin was significantly higher in PCOS women. Circulating irisin levels correlated with 17-hydroxyprogesterone, testosterone, and insulin. Three months metformin treatment decreased circulating irisin in PCOS women and improved IR. Circulating irisin is directly associated with insulin resistance in PCOS women and may be used as a biomarker for IR in these patients. Moreover, metformin as a confounding therapy in metabolic diseases can be used to regulate circulating irisin levels in PCOS women.

scholarly journals Association of Thyroid Stimulating Hormone with Insulin Resistance in Women with Polycystic Ovarian Syndrome

2016 ◽  
Vol 11 (1) ◽  
pp. 69-73
Author(s):  
Salma Naher ◽  
Sultana Rajia Begum ◽  
Liaquat Ali ◽  
Maksumul Hakim
Keyword(s):  
Insulin Resistance ◽  
Insulin Sensitivity ◽  
Subclinical Hypothyroidism ◽  
Polycystic Ovarian Syndrome ◽  
Thyroid Stimulating Hormone ◽  
Model Assessment ◽  
C Peptide ◽  
Ovarian Syndrome ◽  
Serum Tsh ◽  
Stimulating Hormone

Introduction: Polycystic Ovarian Syndrome (PCOS) is a major cause of female infertility which is thought to be associated with Insulin Resistance (IR). However the nature and degree of IR have been shown to vary in different populations. PCOS women have also been reported to have increased prevalence of subclinical hypothyroidism which has been postulated to be determinants of IR. The natures of thyroid involvement have also been shown to vary between populations.Objectives: The study was undertaken to explore the distribution of IR and thyroid dysfunction as assessed by Thyroid Stimulating Hormone (TSH) levels among PCOS subjects and also to investigate the association of IR with TSH in women with PCOS.Materials and Methods: One hundred and fifty one PCOS patients (age in years 24±5; M±SD) were studied. PCOS was diagnosed by Rotterdam criteria. Fasting serum C-peptide was measured by Enzyme Linked Immuno Sorbide Essay (ELISA) and serum TSH was measured by Microparticle Enzyme Immunoassay (MEIA). Serum glucose was estimated by Glucose-Oxidase method (GOD-PAP). Insulin sensitivity was assessed by using Homeostasis Model Assessment (HOMA).Results: The mean serum C-peptide (nmol/l) and HOMA%S were 0.67 (±0.35) and 85 (±42) respectively. The median (Range) serum TSH level (?lU/ml) of the study subjects was found to be 2.49 (0.66 to 20.86). Insulin sensitivity was found to be 26%, 47%, 17% and 10% in those who had HOMA%S level at the range of <50, 50-100, 101-150 and >150 respectively. Of the total PCOS subjects, 85% had normal level of TSH value whereas only 15% PCOS subjects had subclinical hypothyroidism. The median serum TSH level of the insulin resistance and non-resistance groups were 2.25 (0.89-5.71) and 2.58 (0.74-20.86) respectively. On Pearson's correlation analysis insulin sensitivity was not found to be any significant association with TSH in the PCOS subjects.Conclusion: The study revealed that there was no significant association with IR and TSH in the PCOS subjects.Journal of Armed Forces Medical College Bangladesh Vol.11(1) 2015: 69-73

scholarly journals Randomised controlled trial: comparing effects of metformin versus myoinositol versus metformin and myoinositol on ovarian functions and metabolic factors in polycystic ovarian syndrome

2020 ◽  
Vol 9 (6) ◽  
pp. 2542
Author(s):  
Shikha Singh Thakur ◽  
Shaheen Anjum ◽  
S. S. Siddiqui
Keyword(s):  
Insulin Resistance ◽  
Polycystic Ovarian Syndrome ◽  
Controlled Trial ◽  
P Value ◽  
Cutaneous Manifestations ◽  
Treatment Groups ◽  
Comparative Clinical Study ◽  
Group B ◽  
Randomised Controlled ◽  
Ovarian Syndrome

Background: Polycystic ovarian syndrome (PCOS) characterized by anovulation and features of hyperandrogenism (clinical or biochemical) and insulin resistance. Metformin and myoinositol being insulin sensitizers improve clinical and biochemical parameters. This study was done to compare the effects of these drugs on clinical features and biochemical profile.Methods: A randomized, comparative, clinical study was conducted on 72 patients. The patients were randomized with the help of computer-generated random numbers and were allocated to either of the three treatment groups A, B and C. Patients in group A received metformin 500 mg TDS, group B received myoinositol 1000 mg BD, group C received combination of metformin 500 mg and myoinositol 550 mg BD for 24 weeks. At first visit patients detailed history and baseline investigations were recorded. Follow up was done 24 weeks after start of therapy to assess the improvement in clinical and biochemical profile.Results: There was significant improvement in menstrual irregularities, cutaneous manifestations, pregnancy rate, LH/FSH ratio, insulin sensitivity and HOMA-IR after 24 weeks of treatment in all three groups (p value <0.05), although there was greater improvement in cases treated with combination of metformin and myoinositol than metformin and myoinositol alone.Conclusions: The combination of metformin and myoinositol has resulted in more significant reduction in insulin resistance and improvement in metabolic and hormonal profile along with regularization of menstrual cycles and spontaneous conception than metformin and myoinositol alone.

Polycystic ovarian syndrome: Correlation between hyperandrogenism, insulin resistance and obesity

2020 ◽  
Vol 502 ◽  
pp. 214-221 ◽  
Author(s):  
Xin Zeng ◽  
Yuan-jie Xie ◽  
Ya-ting Liu ◽  
Shuang-lian Long ◽  
Zhong-cheng Mo
Keyword(s):  
Insulin Resistance ◽  
Polycystic Ovarian Syndrome ◽  
Ovarian Syndrome

scholarly journals Subclinical Hypothyroidism in PCOS: Impact on Presentation, Insulin Resistance, and Cardiovascular Risk

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Qun Yu ◽  
Jin-Bei Wang
Keyword(s):  
Cardiovascular Risk ◽  
Subclinical Hypothyroidism ◽  
Polycystic Ovarian Syndrome ◽  
Normal Population ◽  
Statistical Significance ◽  
Cardiovascular Disorder ◽  
Control Subjects ◽  
Increased Risk ◽  
Pcos Group ◽  
Ovarian Syndrome

Aim of Study. To assess status of thyroid function and thyroid disorders particularly subclinical hypothyroidism (SCH) in subjects with polycystic ovarian syndrome (PCOS) and impact of SCH on various clinical and biochemical parameters and cardiovascular risk in PCOS.Methods. Hundred females diagnosed with PCOS as per Rotterdam criteria and 100 normal controls were recruited and were subjected to elaborate anthropometric, clinical, and biochemical assessment.Results. Notable findings included significantly higher frequency of subjects with subclinical hypothyroidism (p=0.0002), autoimmune thyroiditis (p<0.001), and goitre (p=0.02) in polycystic ovarian syndrome subjects compared to control subjects. Further SCH PCOS subjects were found to harbor significantly higher HOMA-IR (p<0.05) and frequency of subjects with dyslipidemia (p<0.05) compared to both euthyroid PCOS and euthyroid control subjects. Though frequency of subjects with cardiovascular risk factors was higher in SCH PCOS group than euthyroid PCOS group, it failed to reach statistical significance.Conclusion. We concluded that PCOS is associated with high incidence of SCH and AIT compared to normal population and SCH poses increased risk of cardiovascular disorder in PCOS.

scholarly journals Role of insulin sensitising agents in altering PSA level in PCOS

2017 ◽  
Vol 6 (11) ◽  
pp. 4986 ◽  
Author(s):  
Rajashree Panigrahy ◽  
Bratati Singh ◽  
Tapan K. Pattnaik ◽  
Sanjukta Misra
Keyword(s):  
Insulin Resistance ◽  
Polycystic Ovarian Syndrome ◽  
Specific Antigen ◽  
Serum Testosterone ◽  
Healthy Controls ◽  
Androgen Excess ◽  
Control Serum ◽  
Ovarian Syndrome ◽  
Significant Concentration

Background: Ovarian androgen production can be promoted by insulin resistance which leads to reproductive abnormalities in Polycystic Ovarian Syndrome (PCOS). A wide variety of female tissues can synthesize and secrete Prostate Specific Antigen (PSA). Androgens may take part a significant role in PSA secretion in PCOS. As insulin resistance stimulates androgen production, the baseline value of PSA may decline by insulin sensitising agents in PCOS. Present study is an attempt to measure the function of PSA as a marker of androgen excess in PCOS and to assess the role of insulin sensitising agent metformin in altering PSA level in PCOS.Methods: The study was undertaken to assess the insulin resistance, testosterone and PSA level in 45 women diagnosed as PCOS and 45 healthy controls. Alteration of insulin resistance, serum testosterone and PSA levels by metformin was also analysed.Results: A significant increase in testosterone, PSA level and insulin resistance was observed in PCOS cases when compared with control (p<0.001). When metformin was given for 4 months, improvement in insulin resistance and testosterone level was found in cases, but PSA values observed no change. Correlation was not found linking insulin resistance with PSA level prior to and after therapy.Conclusions: Serum PSA level could be detected in high significant concentration in PCOS women. Various researches explain that insulin resistance and BMI may perhaps control serum PSA level, but our result demonstrate no effect of insulin sensitising agent on serum PSA value.

Sign in / Sign up

Export Citation Format

Share Document