scholarly journals The Comparative Study of Atopic Dermatitis and Chronic Hand Eczema Clinical Course in Adults after Acute Relapse Treatment

2021 ◽  
pp. 373-379
Author(s):  
Aleksandruk Oleksandr Dmytrovych ◽  
Stepanenko Roman Leonidovich ◽  
Ali Mohammed ◽  
Stepanenko Viktor Ivanovich ◽  
Tetiana Konovalova ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Disease Severity ◽  
Hand Eczema ◽  
Skin Care ◽  
Adult Patients ◽  
Sample Population ◽  
Relapse Treatment ◽  
Chronic Hand Eczema ◽  
Acute Relapse ◽  
Anti Inflammatory

Aims: To evaluate Atopic dermatitis (AD) and Chronic hand eczema (CHE) course in adults after discontinuation of acute or sub acute relapse treatment. Study Design: three groups of adult patients that finished standard treatment for relapse of AD and CHE were followed up within 24 weeks of period to check disease severity, itch intensity and skin management effectiveness. Place and Duration of Study Sample: population of Ivano-Frankivsk region of Ukraine September 2015 – May 2021. Methods: 155 patients (51 females and 104 males; age between 20 and 50 years) with AD or CHE were enrolled in the study. The patients were randomized into three study groups depending on diagnosis. SCORAD index was used to assess disease severity, visual analog scale (VAS) was used to assess skin itch intensity. Frequency of disease treatment re-start with topical or systemic anti-inflammatory drugs as well as patients’sintention to ask for a treatment were calculated. Results: Results of our study have shown that cases of new disease worsening occured within nearest 24 weeks after AD and CHE aggravation treatment discontinuation and are quite frequent despite appropriate skin care. Conclusion: part of adult patients continues suffering from skin itch or mild skin lesions within nearest 24 weeks after discontinuation of intensive treatment of AD or CHE relapse. Prescription of antihistamines and/or topical anti-inflammatory treatment in addition to generally recommended skin care with emollients is crucial for patients with new worsening of the disease. Among patients with a new signs of worsening a part would unlikely ask for a new treatment immediately unless this worsening is moderate or severe.

scholarly journals Skin Microbiome in Patients with Hand Eczema and Healthy Controls: A Three-week Prospective Study

2021 ◽  
Author(s):  
Line Brok Nørreslet ◽  
Berit Lilje ◽  
Anna Cäcilia Ingham ◽  
Sofie Marie Edslev ◽  
Maja-Lisa Clausen ◽  
...  
Keyword(s):  
Prospective Study ◽  
Disease Severity ◽  
Amplicon Sequencing ◽  
Hand Eczema ◽  
Skin Microbiome ◽  
Healthy Controls ◽  
16S Rrna Amplicon Sequencing ◽  
Chronic Hand Eczema ◽  
Α Diversity ◽  
Underlying Mechanisms

The pathogenesis of chronic hand eczema remains unclear. Insights into the skin microbiome in hand eczema and its potential relevance to disease severity may help to elucidate the underlying mechanisms of hand eczema. The aim of this study was to characterize the microbiome in patients with hand eczema and healthy controls. A 5-visit prospective study was conducted over a period of 3 weeks. At each visit, bacterial swabs were taken from the hands of patients with hand eczema and controls. The microbiome was examined using DNA extraction and 16S rRNA amplicon sequencing (V3–V4 regions). Fifty patients with hand eczema and 50 controls were included (follow-up rate=100%). The baseline bacterial α-diversity was reduced on the hands of patients with hand eczema compared with controls (effect size=–0.31; 95% confidence interval (95% CI) –0.50; –0.11; p = 0.003). The dysbiosis on the patients’ hands was stable over the study period, was associated with disease severity, and was characterized by reduced bacterial diversity and different bacterial community compositions.

Salivary chromogranin A levels correlate with disease severity but do not reflect anxiety or personality of adult patients with atopic dermatitis

2017 ◽  
Vol 44 (8) ◽  
pp. 920-926 ◽  
Author(s):  
Sakae Kaneko ◽  
Lijuan Liu ◽  
Takeyasu Kakamu ◽  
Masako Minami-Hori ◽  
Eishin Morita
Keyword(s):  
Atopic Dermatitis ◽  
Disease Severity ◽  
Chromogranin A ◽  
Adult Patients

Approach to the Assessment and Management of Adult Patients With Atopic Dermatitis: A Consensus Document. Section II: Tools for Assessing the Severity of Atopic Dermatitis

2018 ◽  
Vol 22 (1_suppl) ◽  
pp. 10S-16S ◽  
Author(s):  
Melinda J. Gooderham ◽  
Robert Bissonnette ◽  
Parbeer Grewal ◽  
Perla Lansang ◽  
Kim A. Papp ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Disease Severity ◽  
Rating Scale ◽  
Numerical Rating Scale ◽  
Life Quality ◽  
Severity Index ◽  
Adult Patients ◽  
Physician Global Assessment ◽  
Atopic Dermatitis Severity ◽  
Patient Reported

Clinicians rely on clinical measures to define the severity of atopic dermatitis and assess outcomes of therapy. These measures can be objective (ie, physician assessments of disease severity) or subjective (ie, patient-reported symptoms and quality of life outcomes). In this review, the most commonly used tools for assessing atopic dermatitis severity in adult patients are presented and compared. These include Eczema Area and Severity Index (EASI); SCORing Atopic Dermatitis (SCORAD); Physician Global Assessment (PGA); body surface area (BSA); Atopic Dermatitis Severity Index (ADSI); Six Area, Six Sign Atopic Dermatitis (SASSAD); Patient Oriented Eczema Measure (POEM); Dermatology Life Quality Index (DLQI); and pruritus Numerical Rating Scale (NRS). Available severity strata for the tools are summarized, although the use of severity strata in clinical practice is not recommended. Since both objective and subjective assessments of disease severity are important to assess, consideration of clinical characteristics such as disease recurrence or persistence, as well as location of the affected areas, should be considered in the overall judgement of disease severity and consideration of therapy choice.

scholarly journals Sensitization to Skin-associated Microorganisms in Adult Patients with Atopic Dermatitis is of Importance for Disease Severity

2013 ◽  
Vol 93 (3) ◽  
pp. 340-345 ◽  
Author(s):  
A Sonesson ◽  
J Bartosik ◽  
J Christiansen ◽  
I Roscher ◽  
F Nilsson ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Disease Severity ◽  
Adult Patients

scholarly journals Impact of Atopic Dermatitis and Chronic Hand Eczema on Quality of Life Compared With Other Chronic Diseases

Dermatitis ◽  
2020 ◽  
Vol 31 (3) ◽  
pp. 178-184 ◽  
Author(s):  
Silvia Capucci ◽  
Julie Hahn-Pedersen ◽  
Andreas Vilsbøll ◽  
Nana Kragh
Keyword(s):  
Quality Of Life ◽  
Atopic Dermatitis ◽  
Chronic Diseases ◽  
Hand Eczema ◽  
Chronic Hand Eczema
Sign in / Sign up

Export Citation Format

Share Document