Advances in Nanomaterials-Based Carrier System for the Treatment of Breast Cancer

Nanotherapeutics for the cure of breast cancer remains unswervingly succeeding and being practiced to eradicate innumerable restrictions of conventional practice obtainable for the supervision of breast cancer. Nanoparticles offer an interdisciplinary extent for exploration in imaging, diagnosis and targeting of breast cancer. Through a progressive physicochemical features and improved bioavailability, they spectacle persistent blood circulation through effective tumor targeting. Nanoparticles remain capable to diminish cytotoxic consequence of the active anticancer medications through amassed cancer cell targeting in contrast to conventional preparations. Several nanoparticles-based preparations remain in the preclinical and clinical phases of progress; amongst them, polymeric drug micelles, liposomes, and dendrimer, remain the utmost common. In this review, we have conferred the role of nanoparticles through detail to oncology, by predominantly aiming on the breast cancer and several nanodelivery systems practiced for targeting action and signaling forces through further intracellular pathways in breast cancer.

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Nanocarriers for Diagnosis and Targeting of Breast Cancer

BioMed Research International ◽

10.1155/2013/960821 ◽

2013 ◽

Vol 2013 ◽

pp. 1-10 ◽

Cited By ~ 23

Author(s):

Arun Sharma ◽

Nitin Jain ◽

Rashmi Sareen

Keyword(s):

Breast Cancer ◽

Blood Circulation ◽

Tumor Targeting ◽

Cytotoxic Effect ◽

Imaging Diagnosis ◽

Passive Targeting ◽

Specific Tumor ◽

Polymeric Drug ◽

Cancer Cell Targeting

Breast cancer nanotherapeutics is consistently progressing and being used to remove the various limitations of conventional method available for the diagnosis and treatment of breast cancer. Nanoparticles provide an interdisciplinary area for research in imaging, diagnosis, and targeting of breast cancer. With advanced physicochemical properties and better bioavailability, they show prolonged blood circulation with efficient tumor targeting. Passive targeting mechanisms by using leaky vasculature, tumor microenvironment, or direct local application and active targeting approaches using receptor antibody, amplification in the ability of nanoparticles to target specific tumor can be achieved. Nanoparticles are able to reduce cytotoxic effect of the active anticancer drugs by increasing cancer cell targeting in comparison to conventional formulations. Various nanoparticles-based formulations are in the preclinical and clinical stages of development; among them, polymeric drug micelles, liposomes, dendrimer, carbon nanotubes, and nanorods are the most common. In this review, we have discussed the role of nanoparticles with respect to oncology, by particularly focusing on the breast cancer and various nanodelivery systems used for targeting action.

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The role of imaging techniques in the diagnosis, staging and choice of therapeutic conduct in pregnancy associated breast cancer

Medical Ultrasonography ◽

10.11152/mu-1958 ◽

2019 ◽

Vol 21 (3) ◽

pp. 336

Author(s):

Iulian Goidescu ◽

Georgiana Nemeti ◽

Gabriela Caracostea ◽

Dan Tudor Eniu ◽

Angelica Chiorean ◽

...

Keyword(s):

Breast Cancer ◽

Side Effects ◽

Adverse Effects ◽

Imaging Techniques ◽

Diagnostic Techniques ◽

Imaging Diagnosis ◽

The Postponement ◽

Therapeutic Possibilities ◽

In Pregnancy

Breast cancer diagnosed during pregnancy is at increasing incidence due to the increased frequency of obesity, the postponement of the first pregnancy to later decades of life and the advances of diagnostic techniques. Clinical and imaging diagnosis is difficult during gestation due to adaptive changes of the maternal organism , the mammary glads in particular. Furthermore, the therapeutic approach is limited both by the possible side effects on the fetus and by the skepticism of the couple over these therapeutic regimens.The present paper aims to review the main diagnostic steps to confirm pregnancy associated breast cancer, as well as the therapeutic possibilities during this period, related to the potential adverse effects concerning pregnancy

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