scholarly journals Prevalence of Malignancy in Solitary Thyroid Nodule-A Retrospective Study

2021 ◽  
pp. 903-907
Author(s):  
A. Kavya ◽  
K. R. Manoj Prabu
Keyword(s):  
Retrospective Study ◽  
Thyroid Nodule ◽  
Histopathological Examination ◽  
Clinical Specimen ◽  
Preoperative Assessment ◽  
Cost Effective ◽  
Needle Aspiration ◽  
Vital Role ◽  
Female Ratio ◽  
Solitary Thyroid Nodule

Background: Solitary thyroid nodule is defined as discrete mass palpable in an otherwise apparently normal thyroid gland.  Solitary nodule is the common presentation of thyroid disorders. Objective: This study aimed to look into the prevalence of malignancy in clinico-radiologically detected solitary thyroid nodule and to correlate the findings in pre-operative fine needle aspiration cytology(FNAC) and post-operative histopathological examination(HPE). Materials and Methods: A retrospective study was carried out in our Institute for a period of 6 months using the data obtained between 2018-2020 of patients who were clinically and radiologically diagnosed as solitary thyroid nodule in the Department of General Surgery. Results: Out of 30 cases of clinically detected solitary thyroid nodule 7(23.3%)cases was found to be malignant. The mean age of presentation was 41.2 years with male female ratio of 1:9. 25(83.3%)cases was reported as benign nodules according to pre-operative FNAC out of these 2(6.6%)cases turned out to be malignant on post-operative histopathological examination. Conclusion: It is concluded that from the present study the prevalence of malignancy in clinically detected solitary thyroid nodule is 23.3%. FNAC being sensitive, cost effective and reliable tool in the preoperative assessment of solitary thyroid nodules and HPE in post operative evaluation of clinical specimen both playing a vital role in management of solitary thyroid nodule thus helping in early diagnosis and proper surgical intervention.

scholarly journals FNAC IN THE MANAGEMENT OF SOLITARY THYROID NODULE

2006 ◽  
Vol 13 (04) ◽  
pp. 596-603
Author(s):  
SOHAIL RAZA ◽  
HAMAD RAZA ◽  
ZAHID SAEED ◽  
Mubasher Ahmed
Keyword(s):  
Thyroid Nodule ◽  
Thyroid Nodules ◽  
Fine Needle Aspiration Biopsy ◽  
Cost Effective ◽  
Needle Aspiration ◽  
Military Hospital ◽  
Solitary Thyroid Nodule ◽  
Benign Nodules ◽  
Histopathological Results

Objective: To determine the significant role of FNAC upon other diagnosticmodalities in pre-operative investigations of patients presenting with solitary thyroid nodules and to compare the postoperative histopathological results with the results of FNAC. Design: A Comparative study. Place and Duration ofStudy: Department of Surgery Combined Military Hospital Quetta and Combined Military Hospital Rawalpindi fromDecember 1999 to December 2001. Patients and Methods: In this study 46 patients with solitary thyroid nodule werestudied. Only 2 patients were toxic while remaining 44 were with euthyroid. In this study only one case was suspectedto be malignant clinically out of 5 malignant cases. All 46 patients under went thyroid scanning, ultrasound examinationand fine needle aspiration biopsy and the diagnostic accuracy was assessed. Results: 36 patients (78.26%) wereoperated while 10(21.73%) were managed conservatively. There were 5(10.86%) malignant nodules while 41(89.13%)were benign. All the 5 cases with malignancy were with ‘cold’ nodules on scan as most of others, while ‘solid’ onultrasound examination and so were most of other benign nodules. All cases diagnosed malignant pre-operatively onFNAC, proved to be malignant on histopathology after surgery and the others diagnosed as benign on FNAC provedto be benign. Conclusion: This study shows that conventional investigations for evaluation of solitary thyroid nodulesare inaccurate in identifying the malignant from the benign nodules and their routine use in such patients should beabandoned, while the use of FNAC should be encouraged more in our hospitals as this technique is with high degreeof sensitivity and specificity, cost effective and safe.

scholarly journals Frequency & pattern of malignancy in solitary thyroid nodule

1970 ◽  
Vol 15 (1) ◽  
pp. 1-5
Author(s):  
Md Rafiqul Islam ◽  
AFM Ekramuddaula ◽  
MS Alam ◽  
MS Kabir ◽  
Md Delwar Hossain ◽  
...  
Keyword(s):  
Thyroid Nodule ◽  
Papillary Carcinoma ◽  
Histopathological Examination ◽  
Malignant Lesion ◽  
Medullary Carcinoma ◽  
College Hospital ◽  
Frequency Pattern ◽  
Cross Sectional ◽  
Female Ratio ◽  
Solitary Thyroid Nodule

This cross sectional study done in the department of Banghabandhu Sheikh Mujib Medical University and Dhaka Medical College Hospital during the period of July 2005 to October 2007 to determine frequency & pattern of malignancy in solitary thyroid nodule. For this study, 118 patients who were diagnosed as a case of malignancy in solitary thyroid nodule by detailed history, clinical examination, thyroid hormone assay, ultrasonogram, thyroid scan, FNAC and histopathological examination, were collected. In this study majority of the patients were within 21-40 years of age. Frequency of solitary thyroid nodule is more in female with male female ratio 1: 2.11 Majority of the nodules were firm (72.03%), others were hard (16.95%) and cystic (11.02%). Malignant lesion was more common in hard nodule (70%). Most of the nodules were cold (66.10%) among them 25.6% cases were malignant, followed by warm (30.5%) and hot (3.3%). No malignancy was found in hot nodule. FNAC showed colloid nodule (44%), cellular follicular lesion (29.66%), papillary carcinoma (12.7%), colloid degeneration (4.2%) and medullary carcinoma (1.6%) Out of 118 patients, histopathologically non malignant were 96 (81.35%) and malignant were 22(18.65%). Among malignant cases, 16 (72.72%) cases were papillary carcinoma, 4 (18.18%) cases were follicular carcinoma and 2(9.1%) cases were medullary carcinoma. Key words: Solitary thyroid nodule, FNAC, Papillary carcinoma, Follicular carcinomaDOI: 10.3329/bjo.v15i1.4303 Bangladesh J of Otorhinolaryngology 2009; 15(1): 1-5

scholarly journals Clinicopathological study of solitary thyroid nodule in Kolhan belt of Jharkhand

2021 ◽  
Vol 7 (6) ◽  
pp. 959
Author(s):  
Rajeev Saxena ◽  
Shiwani Kanth ◽  
Rohit Kumar Jha ◽  
Devandra Jee
Keyword(s):  
Diagnostic Accuracy ◽  
Thyroid Nodule ◽  
Predictive Value ◽  
Thyroid Nodules ◽  
Histopathological Examination ◽  
Follicular Adenoma ◽  
Daily Practice ◽  
Needle Aspiration ◽  
Age Group ◽  
Solitary Thyroid Nodule

<p class="abstract"><strong>Background:</strong> Thyroid disorders are commonly encountered in our daily practice and specially in countries like India and Nepal (foothill areas). There are variety of lesions that can arise within thyroid gland. In such scenario it is important to diagnose neoplastic and non-neoplastic conditions accurately with minimum complications so that proper management can be done as early as possible. The aim of the study was to know clinical spectrum of solitary thyroid nodules and diagnostic accuracy of fine needle aspiration cytology as compared to histopathological examination.</p><p class="abstract"><strong>Methods:</strong> We conducted our study over a period of 21 months from July 2018 to March 2020. 74 patients who gave consent and presented with solitary thyroid swelling were included in the study.  </p><p class="abstract"><strong>Results:</strong> In our study, cases mostly presented in the age group of 31-40 years with a female preponderance. Colloid goiter was the most common pathology which presented as solitary thyroid nodule. Among neoplastic lesions, follicular adenoma was the most common benign neoplasia with papillary thyroid carcinoma being the most common malignancy. FNAC had sensitivity of 78%, specificity-100%, positive predictive value-100%, negative predictive value-88% and diagnostic accuracy-92%.</p><p class="abstract"><strong>Conclusions:</strong> Majority of solitary thyroid nodules are found in females of middle age group. In our study we found FNAC as valuable diagnostic tool specially in benign cases.</p><p class="abstract"> </p><p> </p>

scholarly journals Clinico pathological aspects of solitary thyroid nodule: a hospital based prospective study

2018 ◽  
Vol 5 (5) ◽  
pp. 1852
Author(s):  
S. Rajendran ◽  
K. R. Manoj Prabu
Keyword(s):  
Prospective Study ◽  
Thyroid Nodule ◽  
Clinical Diagnosis ◽  
Histopathological Examination ◽  
Needle Aspiration ◽  
Thyroid Disorder ◽  
Nodular Goitre ◽  
Solitary Nodule ◽  
Solitary Thyroid Nodule ◽  
Thyroid Swelling

Background: Nodular goitre is a common endocrine problem in the world today. Solitary thyroid nodule is defined as the presence of a palpable nodule in the otherwise normal thyroid gland. Solitary nodules are one of the most frequent presentations of thyroid disorder. The aim of this study was to study the incidence and other clinical parameters of solitary thyroid nodules and to correlate between clinical diagnosis and histopathological examination of solitary nodule thyroid.Methods: A prospective study was done in patients with solitary thyroid swelling, after taking a detailed history, were examined clinically and confirmed with FNAC and underwent thyroid surgery were included in this study. The histopathological reports were evaluated and correlated with clinical diagnosis by standard statistical methods.Results: Majority of the patients were between 21-30 years of age. Female:male ratio was about 11.5:1. Swelling in front of the neck was the most common presentation. Most common solitary thyroid swelling was the colloid goitre. Commonest surgery performed was hemithyroidectomy.Conclusions: The majority of the solitary nodule of the thyroid was found to be benign, and this illustrates that hemithyroidectomy is the preferred surgery unless malignancy is suspected by fine needle aspiration cytology.

scholarly journals Correlation of Fine Needle Aspiration Cytology with Histopathology in the Diagnosis of Solitary Thyroid Nodule

2010 ◽  
Vol 2010 ◽  
pp. 1-5 ◽  
Author(s):  
Manoj Gupta ◽  
Savita Gupta ◽  
Ved Bhushan Gupta
Keyword(s):  
Thyroid Nodule ◽  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Cytology ◽  
Thyroid Nodules ◽  
Cost Effective ◽  
Needle Aspiration ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Solitary Thyroid Nodule ◽  
Needle Aspiration Cytology

Background. Fine needle aspiration cytology is considered the gold standard diagnostic test for the diagnosis of thyroid nodules. Fine needle aspiration cytology is a cost effective procedure that provides specific diagnosis rapidly with minimal complications. Based on the cytology findings, patients can be followed in cases of benign diagnosis and subjected to surgery in cases of malignant diagnosis thereby decreasing the rate of unnecessary surgery. Purpose of the present study was to correlate the fine needle aspiration cytology findings with histopathology of excised specimens.Material and Methods. This was a prospective study conducted on 75 consecutive patients between January 2003 and December 2005. All patients with clinically diagnosed solitary thyroid nodule who were clinically and biochemically euthyroid were included for study. Patients with multinodular goitre and who were hypothyroid or hyperthyroid were excluded from the study.Results. The sensitivity, specificity, accuracy, false positive rate, false negative rate, positive predictive value, and negative predictive value of FNAC for the diagnosis of neoplastic solitary thyroid nodules were 80%, 86.6%, 13.3%, 20%, 80%, and 86.6%, respectively. Commonest malignancy detected was papillary carcinoma in 12 patients.Conclusions. Fine needle aspiration cytology is a simple, easy to perform, cost effective, and easily repeated procedure for the diagnosis of thyroid cancer. It is recommended as the first line investigation for the diagnosis of solitary thyroid nodule.

Patients’ Preferences’ Impact on Decision Making for Clinical Solitary Thyroid Nodule in a Global Healthcare Setting: A Clinical Study

2021 ◽  
Vol 3 (2) ◽  
pp. 48-58
Author(s):  
Abdalla Y Bashir ◽  
Keyword(s):  
Decision Making ◽  
Thyroid Nodule ◽  
Thyroid Surgery ◽  
Frozen Section ◽  
Management Strategies ◽  
Healthcare Setting ◽  
Objective Evaluation ◽  
Needle Aspiration ◽  
Solitary Thyroid Nodule ◽  
Risk Of Malignancy

Objective: Evaluation of patients’ preferences (PP) impact on decision-making for solitary thyroid nodule management. Study Design: A retrospective review of prospectively collected data in patients with clinical solitary nodules admitted for thyroid surgery. PP survey in various management strategies included determinants of surgery, fine-needle aspiration cytology (FNAC), frozen section (FS), and PP for total thyroidectomy (TT) or total lobectomy (TL) compared to guidelines concordance. Results: Thyroid surgery was performed for 558 patients, 75.8% were females and 43.7% were international. FNAC was done in 79.8% and refused by 20.2% due to the misperception that it spreads cancer. The risk of malignancy was the reason for choosing surgery in 35.1%. FS was preferred by 87% of the patients for decision-making (TT vs TL) in our setting with available pathology resources and low FS cost. FS based decisions were more guideline-concordant (79%) with TT performed in 41% patients compared to 74.4% in PP based decisions alone (P < 0.001). 57.9% of the patients preferred surgeon authorization for decision-making when FS was unavailable. Papillary thyroid carcinoma (PTC) occurred in 85.3%. FS diagnosed PTC in 79% of the patients with malignant nodules in inconclusive FNACs (Bethesda I, III, IV, and V). Conclusion: Decisions (TT vs TL) based on PP and beliefs compared to FS based decisions were less guideline-concordant (21% vs 79%) with more TT performed (74.4% vs 41%) (P < 0.001). Advancing patients’ knowledge on their disease, guidelines, and equipoise awareness is needed for better-shared decision-making.

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