scholarly journals Bio-Analytical Stability Studies of Nadolol Material

2021 ◽  
pp. 130-140
Author(s):  
B. Veeraswami ◽  
V. M. K. Naveen
Keyword(s):  
Quantitative Measure ◽  
Drug Analysis ◽  
Stability Study ◽  
Stability Studies ◽  
Experimental Conditions ◽  
Long Term Stability ◽  
Analytical Stability ◽  
Ich Guidelines

The best practices of Bio-analytical stability studies on drug samples are very crucial and essential for the drugs development process as it specify the acceptancy, purity, efficacy, prediction of strength and quality of the drugs. The main objective of this stability studies on Nadolol the proposed approach of chromatographic separation was administered in isocratic way by using asymmetric C18 column of 40:60 percent of acetonitrile and 0.1% OPA at a flow rate of 1 ml/min is a quantitative measure for drug analysis in biological matrix for more reliable, selective, reproducible and sensitive.  This stability study constituents several methods like Bench-Top, Auto-sampler, Freeze-Thaw, Dry-extract, Wet-extract, Short-term, long-Term stability studies at various intervals gave the complete stability information about these drugs. The results of these stability studies are accepted based on ICH guidelines represents this drug has a good stability under the present experimental conditions. 

scholarly journals Bio-analytical Approach for Stability Studies of Bendroflumethiazide Materials

2021 ◽  
pp. 195-203
Author(s):  
B. Veeraswami ◽  
V. M. K. Naveen
Keyword(s):  
Stability Study ◽  
Stability Studies ◽  
Dry Extract ◽  
Long Term Stability ◽  
Analytical Stability ◽  
Ich Guidelines ◽  
The Stability ◽  
Efficacy Prediction

In this paper a comprehensive study of stability related, and evidence based best practices of Bio-analytical stability on Bendroflumethiazide drug samples are studied. The proposed approach is very significant and essential for the drugs development process address the specify the acceptancy, purity, efficacy, prediction of strength and quality of the drugs. The stability study constituents several methods like Bench-Top, Auto-sampler, Freeze-Thaw, Dry-extract, Wet-extract, Short-term, long-Term stability studies at relative intervals results the complete stability information about the drug under the proposed and validated method. There ported out comes of this methos shows this drug have good stability according to ICH guidelines.

Analysis of Corn Straw Pyrolysis Bio-Oil Composition

2015 ◽  
Vol 737 ◽  
pp. 14-19
Author(s):  
Huan Huan Wei ◽  
Yun Long Liu ◽  
Dong Yu Chen
Keyword(s):  
Fast Pyrolysis ◽  
Fluidized Bed Reactor ◽  
Stability Studies ◽  
Oil Composition ◽  
Corn Straw ◽  
Long Term Stability ◽  
Bio Oil ◽  
Oil Water

The fast pyrolysis of corn straw in the fluidized bed reactor to produce bio-oil, the preliminary qualitative research on the composition of the bio-oil was analyzed by GC-MS to provide the basis for their purification, refining and long-term stability studies. The result shows that: the bio-oil producted by corn straw pyrolysis contains 66 components, mainly containing phenol, furan, acetic acid, propanoic acid, ethanone, vanillin, aldehyde, bio-oil water content is 33% and pH is 3.1, which has a great significance to improve the quality of bio-oil.

Preparation and Long-Term Stability Study of Steel Fiber/Graphite Conductive Concrete

2016 ◽  
Vol 680 ◽  
pp. 361-364 ◽  
Author(s):  
Jun Du ◽  
Cheng Tang ◽  
Bo Jia ◽  
De Zhang ◽  
Qiang Miao
Keyword(s):  
Corrosion Resistance ◽  
Steel Fiber ◽  
Stability Study ◽  
Soil Resistivity ◽  
Grounding Resistance ◽  
Term Stability ◽  
Long Term Stability ◽  
Conductive Fillers ◽  
The Common

The steel fiber/graphite conductive concrete is applied in power system grounding. In high soil resistivity regions, the common methods for reducing the grounding resistance are not practical. It is difficult for grounding resistance of substations to meet the requirements of working earthing and safety earthing. In order to solve this problem, a steel fiber/graphite conductive concrete is developed in this paper. Steel fiber and graphite are added as conductive fillers. The long-term stability of the steel fiber/graphite conductive concrete is studied. The experiment results show that steel fiber/graphite conductive concrete not only maintains excellent conductivity, but also has good mechanical strength and corrosion resistance in 300 days.

Determination of Long-Term Stability and Quality of HT-PEM MEAs

2018 ◽  
Vol 86 (13) ◽  
pp. 301-314
Author(s):  
Maren Rastedt ◽  
Julian Büsselmann ◽  
Tomas Klicpera ◽  
Karsten Reinwald ◽  
Nadine Pilinski ◽  
...  
Keyword(s):  
Term Stability ◽  
Long Term Stability

scholarly journals Validation of the IASI FORLI/Eumetsat ozone products using satellite (GOME-2), ground-based (Brewer-Dobson, SAOZ) and ozonesonde measurements

2018 ◽  
Author(s):  
Anne Boynard ◽  
Daniel Hurtmans ◽  
Katerina Garane ◽  
Florence Goutail ◽  
Juliette Hadji-Lazaro ◽  
...  
Keyword(s):  
A Priori ◽  
Long Term Stability ◽  
Comparison Results ◽  
Independent Observations ◽  
Mean Differences ◽  
A Priori Uncertainty ◽  
The Tropics ◽  
Global Mean

Abstract. This paper assesses the quality of IASI/Metop-A (IASI-A) and IASI/Metop-B (IASI-B) ozone (O3) products (total and partial O3 columns) retrieved with the Fast Optimal Retrievals on Layers for IASI Ozone (FORLI-O3) v20151001 software for nine years (2008–2017) through an extensive inter-comparison and validation exercise using independent observations (satellite, ground-based and ozonesonde). IASI-A and IASI-B Total O3 Columns (TOCs) are generally consistent, with a global mean difference less than 0.3 % for both day- and nighttime measurements, IASI-A being slightly higher than IASI-B. A global difference less than 2.4 % is found for the tropospheric (TROPO) O3 column product (IASI-A being lower than IASI-B), which is partly due to a temporary issue related to IASI-A viewing angle in 2015. Our validation shows that IASI-A and IASI-B TOCs are consistent with GOME-2, Dobson, Brewer and SAOZ retrieved ones, with global mean differences in the range 0.1–2 % depending on the instruments. The IASI-A and ground-based TOC comparison for the period 2008–July 2017 shows good long-term stability (negative trends within 3 % decade−1). The comparison results between IASI-A and IASI-B against smoothed ozonesonde partial O3 columns vary in altitude and latitude, with maximum standard deviation for the 300–150 hPa column (20–40 %) due to strong ozone variability and a priori uncertainty. The worst agreement with the ozonesondes and with UV-vis retrieved TOC [satellite and ground] is found at the southern high latitudes. Compared to ozonesonde data, IASI-A and IASI-B O3 products overestimate the O3 abundance in the stratosphere (up to 20 % for the 150–25 hPa column) and underestimates the O3 abundance in the troposphere (within 10 % for the mid-latitudes and ~ 18 % for the tropics). Based on the period 2011–2016, non-significant drift is found for the northern hemispheric tropospheric columns while a small drift prevails for the period before 2011.

scholarly journals Limitations and Challenges in the Stability of Cysteamine Eye Drop Compounded Formulations

2021 ◽  
Vol 15 (1) ◽  
pp. 2
Author(s):  
Cristina Martín-Sabroso ◽  
Mario Alonso-González ◽  
Ana Fernández-Carballido ◽  
Juan Aparicio-Blanco ◽  
Damián Córdoba-Díaz ◽  
...  
Keyword(s):  
Shelf Life ◽  
Stability Study ◽  
Eye Drops ◽  
Microbiological Analysis ◽  
Nitrogen Gas ◽  
Long Term Stability ◽  
Main Degradation Product ◽  
The Stability ◽  
Unstable Molecule

Accumulation of cystine crystals in the cornea of patients suffering from cystinosis is considered pathognomonic and can lead to severe ocular complications. Cysteamine eye drop compounded formulations, commonly prepared by hospital pharmacy services, are meant to diminish the build-up of corneal cystine crystals. The objective of this work was to analyze whether the shelf life proposed for six formulations prepared following different protocols used in hospital pharmacies is adequate to guarantee the quality and efficacy of cysteamine eye drops. The long-term and in-use stabilities of these preparations were studied using different parameters: content of cysteamine and its main degradation product cystamine; appearance, color and odor; pH and viscosity; and microbiological analysis. The results obtained show that degradation of cysteamine was between 20% and 50% after one month of storage in the long-term stability study and between 35% and 60% in the in-use study. These data confirm that cysteamine is a very unstable molecule in aqueous solution, the presence of oxygen being the main degradation factor. Saturation with nitrogen gas of the solutions offers a means of reducing cysteamine degradation. Overall, all the formulae studied presented high instability at the end of their shelf life, suggesting that their clinical efficacy might be dramatically compromised.

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