Case Report on Squamous Cell Carcinoma of the Lip

Introduction: Lip cancers are the most prevalent oral-maxillary malignancy. Lip cancer can be caused by a number of things, including smoking, exposure to ultraviolet (UV) rays, and drinking alcohol [1] In this article we report a case of lower lip squamous cell carcinoma in a 59 year old male patient who smoked heavily and had a history of direct sun exposure, and uv rays. His case report is important attributable to recurrent axillary metastases occurred after subsequent treatment. Clinical Findings: The patient chief complaint is burning sensation on consumption of hot & spicy food since 3 months, apraxia, difficulty in mastication since 2 months approximately & nerve parenthesis in lower lip. Diagnostic Evaluation: Hemoglobin (HB) -13.2gm,mch-27.9fl,mchc-33.3%, Total red blood cell (RBC) count-4.72million/cu.mm Rdw- 12.7%, Total white blood cell (WBC) count- 16500cu.mm, Monocytes -4%, Granulocytes- 85%, Lymphocytes -10%, Esonophils-2%, Basophilis-0%, Total platelet count-2.68 cu. mm. Histopathology report: A multiple, irregular, reddish, brownish tissue pieces aggregating 1×1cm. selection from given tissue piece shows histopathological features are suggestive of well differentiated squamous cell carcinoma. Therapeutic Intervention: post-chemo hydration, post-chemo drugs, BEP Chemotherapy (Bleomycin, Etoposide, Cisplatin). Summary and Conclusions: The patient who was a 59 years old male was admitted to the oral surgery ward. The patient was diagnosed as having squamous cell carcinoma of the lip and he had complained of having burning sensation on consumption of hot & spicy food over the preceding 3 months, apraxia and difficulty in mastication, over a period of about 2 months, and nerve paresthesia within his lower lip. He underwent mandibulectomy with excision of the tumour. Following radical mandibulectomy and adjuvant chemotherapy and radiotherapy, the patient has remained well with no evidence of metastasis at his 4 months follow-up based upon clinical assessment and radiology imaging which does illustrate that radical surgery, plus chemo-radiation for locally advanced squamous cell carcinoma has been shown to be associated with a good short-term outcome and after further follow-up assessments, the long-term outcome of radical surgery and adjuvant chemotherapy would be known.

Download Full-text

Surgery for recurrent lower lip carcinoma

Kathmandu University Medical Journal ◽

10.3126/kumj.v6i3.1715 ◽

1970 ◽

Vol 6 (3) ◽

pp. 375-378

Author(s):

S Maharjan ◽

M Bista ◽

KC Toran ◽

KD Joshi

Keyword(s):

Squamous Cell Carcinoma ◽

Medical Journal ◽

Case Report ◽

Cell Carcinoma ◽

Key Words ◽

Squamous Cell ◽

Lower Lip ◽

Recurrent Squamous Cell Carcinoma ◽

Lip Carcinoma ◽

Deltopectoral Flap

A 38 year old gentleman presented with recurrent Squamos cell carcinoma of lower lip. He had earlier undergone previous surgeries and radiotherapy. At the time that he presented in KMCTH his lower lip area was much scarred and the tongue was shrunk and unavailable for vermilion reconstruction. This case report is an account of the various treatment carried out to reconstruct the lip. It was done with co-operation of the ENT department. Key words: Recurrent squamous cell carcinoma, Gillies fan flap, Deltopectoral flap, Delay of flaps doi: 10.3126/kumj.v6i3.1715 Kathmandu University Medical Journal (2008), Vol. 6, No. 3, Issue 23, 375-378

Download Full-text

Lumpectomy Combined with Adjuvant Radiotherapy Could Be a Treatment Option for Primary Squamous Cell Carcinoma of the Breast

Journal of Oncology ◽

10.1155/2021/2497227 ◽

2021 ◽

Vol 2021 ◽

pp. 1-7

Author(s):

Wei Xiang Qi ◽

Lu Cao ◽

Cheng Xu ◽

Jiayi Chen

Keyword(s):

Breast Cancer ◽

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Adjuvant Radiotherapy ◽

Cox Regression ◽

Radical Surgery ◽

Primary Squamous Cell Carcinoma ◽

The Impact

Background. To investigate the outcomes of primary squamous cell carcinoma (PSCC) of the breast undergoing radical surgery with or without adjuvant radiotherapy (RT). Materials and Methods. A population cohort with histologically diagnosed PSCC of the breast was identified from the SEER database. The Kaplan–Meier method and Cox-regression proportional hazards model was used to assess the impact of surgical types with or without adjuvant RT on the cause-specific survival (CSS) and overall survival (OS). A retrospective analysis of PSCC between Jan 2010 and Dec 2018 from our institute was performed. Results. A total of 515 patients with PSCC of the breast were included, 254 patients treated with mastectomy (MAST) alone, 78 with MAST + RT, 87 with lumpectomy (LUMP) alone, and 96 with LUMP + RT. The median follow-up time was 118 months (range: 0–379 months). In the multivariate Cox analyses, LUMP + adjuvant RT was an independent prognostic factor for CSS (p = 0.028) and OS (p = 0.048). Patients treated with LUMP + RT had better survival rates than patients who underwent lumpectomy (CSS, p = 0.034; OS, p = 0.0004), MAST alone (CSS, p = 0.0001; OS, p < 0.0001), and MAST + RT (CSS, p = 0.0001; OS, p = 0.0078), while postmastectomy RT did not significantly improve OS (p = 0.062) and CSS (p = 0.67) when compared to MAST alone. In addition, a total of 28 patients with PSCC of the breast were identified from our institute. All of these patients presented with estrogen receptor-negative type, and three of them had HER-2-positive PSCC; the median tumor size was 3 cm (range: 0.5–15 cm). Eight patients were treated with LUMP + adjuvant RT, thirteen with MAST, and seven with MAST + RT. Until the last follow-up of Sep 2021, 26 patients with PSCC were still alive and free of breast cancer, excepting that one patient treated with MAST and one patient with MAST + RT died from breast cancer. Conclusion. PSCC of the breast after radical surgery has a poor prognosis. Adjuvant RT after LUMP significantly improves survival of patients with PSCC of the breast. Further studies are still needed to investigate the role of adjuvant RT in PSCC of the breast after mastectomy.

Download Full-text