scholarly journals Evolving Definition and Diagnostic Criteria of Sepsis

2021 ◽  
pp. 391-397
Author(s):  
V. Rakshana ◽  
A. S. Arunkumar ◽  
Laya Mahadevan
Keyword(s):  
Critical Care ◽  
Systemic Inflammatory Response Syndrome ◽  
Inflammatory Response ◽  
Diagnostic Criteria ◽  
Scoring System ◽  
Routine Care ◽  
Systemic Inflammatory Response ◽  
Ongoing Process ◽  
Healthcare Settings ◽  
Sirs Criteria

For many years, the Systemic Inflammatory Response Syndrome (SIRS) criteria were primarily considered for the diagnosis of sepsis, promoting the importance of inflammation. The definition and dia        gnostic criteria of sepsis has undergone a sizeable metamorphosis from the inception of standardized definitions of sepsis in 1991. In 1991, the American College of Chest Physicians (ACCP) and the Society of Critical Care Medicine (SCCM) convened in Chicago and emphasized that sepsis is an ‘ongoing process’ of infection and considered SIRS score of two or more for diagnosis of sepsis. SOFA scoring system is an easily calculated system using parameters that are usually obtained during routine care of patients. This ensures that delays are avoided from requirement of any special investigations, making it reproducible in any number of healthcare settings.

scholarly journals SYSTEMIC INFLAMMATORY RESPONSE SYNDROME: THE CURRENT STATUS

2018 ◽  
Vol 6 (1) ◽  
pp. 56-61
Author(s):  
Manisha Shrestha ◽  
Anand Kumar
Keyword(s):  
Critical Care ◽  
Intensive Care ◽  
Systemic Inflammatory Response Syndrome ◽  
Inflammatory Response ◽  
Diagnostic Criteria ◽  
Current Knowledge ◽  
Laboratory Diagnosis ◽  
Systemic Inflammatory Response ◽  
Current Status ◽  
American Society

Systemic inflammatory response syndrome (SIRS) is a frequent and serious problem faced by clinicians in day to day practice and is a major factor of intensive care morbidity and mortality. The American College of Chest Physicians and the American Society of Critical Care Medicine in 1991 published definitions and criteria for systemic inflammatory response syndrome.  Since then many researches have been undertaken  to better understand the pathophysiology of systemic inflammatory response syndrome and to determine the accuracy of its diagnostic criteria. The criteria set by the 1991 consensus  is still popularly  used  today. However,  with  the current  knowledge   on this matter many researchers have put forward the need of refinement in the criteria of systemic inflammatory response syndrome defined by 1991 consensus. This article aims to review  the epidemiology, etiology, pathophysiology, laboratory diagnosis,  treatment and the current views regarding SIRS.Journal of Universal College of Medical SciencesVol. 6, No. 1, 2018, Page: 56-61

scholarly journals Antimicrobial utilization pattern in Systemic Inflammatory Response Syndrome positive septicemia: a prospective study in an apex hospital in South Delhi

2019 ◽  
Vol 8 (3) ◽  
pp. 557
Author(s):  
Anwer Habib ◽  
Razi Ahmad
Keyword(s):  
Septic Shock ◽  
Severe Sepsis ◽  
Systemic Inflammatory Response Syndrome ◽  
Inflammatory Response ◽  
High Risk Patient ◽  
Systemic Inflammatory Response ◽  
Early Initiation ◽  
Source Of Infection ◽  
Sepsis And Septic Shock ◽  
Sirs Criteria

Background: Despite significant advances in critical care, mortality and morbidity in severe sepsis and septic shock remain high, this may be explained by the fact that in sepsis bacterial infection triggers the innate immune response, setting in motion a cascade of pro-inflammatory and anti-inflammatory cytokines leading to what we recognize as the systemic inflammatory response syndrome (SIRS). It has been thought that this self-propagating cascade drives the progression to severe sepsis and septic shock with increasing degrees of cellular injury and end-organ dysfunction, therefor early initiation of empirical antimicrobial agent is crucial and life-saving atleast in high risk patient. This study aimed to see the outcome (recover or mortality) of patients diagnosed by using SIRS criteria.Methods: Total of 105 patients of suspected sepsis fulfilling SIRS criteria (SIRS ≥2), were included in study. Study population were administered appropriate empirical antimicrobial depending on the source of infection and followed till the final outcome (complete recovery or death).Results: Out of 105 patients included in study based on SIRS criteria, 87 (82.85%) were confirmed to be having septicemia on further evaluation. In majority of patient primary source of infection were respiratory tract (44.76%) and most commonly employed and effective empirical antimicrobial were a combination piperacillin with tazobactum and amikacin (40%). 92.39% patients recovered with empirical antimicrobial, with total in-hospital mortality rate of 7.61%.Conclusions: Early initiation of appropriate antimicrobial by using SIRS as an indicator for the early diagnosis of septicemia is crucial in the management of septicemia and prevention of development of severe sepsis, septic shock.

Systemic Inflammatory Response Syndrome and Sepsis in the Pregnant Patient

2017 ◽  
Author(s):  
Daria M. Moaveni
Keyword(s):  
Systemic Inflammatory Response Syndrome ◽  
Inflammatory Response ◽  
Pregnant Women ◽  
Diagnostic Criteria ◽  
Fluid Management ◽  
Pregnant Patient ◽  
Antimicrobial Treatment ◽  
Systemic Inflammatory Response ◽  
Maternal Morbidity And Mortality ◽  
Resuscitation Fluid

The chapter “Systemic Inflammatory Response Syndrome and Sepsis in the Pregnant Patient” reviews diagnostic criteria for sepsis in pregnant women, as well as the etiology, risk factors, workup, and treatment of this preventable and treatable cause of maternal morbidity and mortality. It also briefly reviews the history and epidemiology of sepsis. It compares the original diagnostic criteria for systemic inflammatory response syndrome established in 1992, the sepsis diagnostic criteria from the Surviving Sepsis Campaign, and the Sepsis in Obstetrics Score. It discusses the initial workup and resuscitation, fluid management, vasopressor choice and dosing, and antimicrobial treatment for pregnant women with sepsis. It also reviews the obstetric implications of septic parturients.

Sign in / Sign up

Export Citation Format

Share Document