scholarly journals Primary Orbital Lymphoma – A Rare Challenging Diagnostic Entity

2020 ◽  
pp. 18-21
Author(s):  
Nisha Marwah ◽  
Niti Dalal ◽  
Manali Satiza ◽  
Sunita Singh
Keyword(s):  
B Cell ◽  
Lymphoproliferative Disorder ◽  
Histopathological Examination ◽  
Final Diagnosis ◽  
Primary Diagnosis ◽  
Cell Type ◽  
Non Hodgkin Lymphoma ◽  
Immunohistochemical Markers ◽  
Orbital Lymphoma ◽  
Hodgkin's Lymphomas

The diagnosis of lymphoproliferative disorder of orbit is quite challenging as both Pseudolymphomas and Non‑Hodgkin’s lymphomas can occur in orbit. Primary orbital lymphoma is a rare entity comprising of 1-2% of Non‑Hodgkin’s lymphoma, majority of them are B‑cell type. It is a slow growing tumor. It presents in the age group of 50–70 years, with a slight female preponderance. Proptosis is the most common presentation. We, herein, report a case of 48 years old male presenting with right non-axial proptosis, watering of eye, blurring of vision and redness for the last 9 months. After thorough clinical and radiological evaluation, a biopsy was taken for histopathological examination. A primary diagnosis of Lymphoproliferative Disorder was made. Following this, a panel of immunohistochemical markers was applied and a final diagnosis of Non-Hodgkin Lymphoma, B-cell type was given.

Niespecyficzny obraz chłoniaka B-komórkowego u dwuipółletniej dziewczynki – opis przypadku

2019 ◽  
Vol 24 (3) ◽  
Author(s):  
Ewa Krasuska-Sławińska ◽  
Izabela Królik-Elgas ◽  
Marzena Stypińska ◽  
Anna Matosek-Rutkowska
Keyword(s):  
B Cell ◽  
Hodgkin Lymphoma ◽  
Histopathological Examination ◽  
B Cell Lymphoma ◽  
Final Diagnosis ◽  
Lymphoblastic Lymphoma ◽  
Final Conclusion ◽  
Dental Surgery ◽  
Non Hodgkin Lymphoma ◽  
Primary Location

B-cell lymphoblastic lymphoma which is a type of non-Hodgkin lymphoma is rather uncommon in children. Focal changes in bones in the course of non-Hodgkin lymphoma are mostly secondary changes and their primal location in a bone is rare. PBL (primary bone lymphoma) mainly concerns a thighbone and a tibial bone; the primary location in jaw bones is quite sporadic. In diagnostics, there is mainly magnetic resonance, medical scan (tomography), and above all – histopathological test. There is also chemotherapy by choice, and primary location in a jaw or a mandible significantly advances the prognosis. The aim of the work is to introduce a patient who was definitively diagnosed B-cell lymphoblastic lymphoma from the early B-cells. The girl reported to Laryngological Clinic, Dental Surgery Clinic for Children, Oncological Clinic of Children’s Memorial Health Institute. The cause of the visit was an elevation on the right side of a nose base, present for two months and misdiagnosed by doctors as a post-traumatic swelling in this region. After introducing laboratory and scan diagnostics and taking biopsy from the lesion, a final conclusion was made. Also, a proper treatment according to the protocol for B-cell lymphoblastic lymphoma was introduced. Non-specific B-cell lymphoma picture, as mentioned in the described case, specifically due to location in a jaw bone and a slow pace of growing, may both constitute huge diagnostic problems and deteriorate prognosis. Therefore, it is important to take into account also lymphoma – in such location of a lesion. Moreover, it is worth remembering that the final diagnosis may only be passed on the basis of histopathological examination.

Intravascular large B-cell lymphoma presenting with reticular telangiectasia on the trunk and panhypopituitarism: an autopsy case

2021 ◽  
Vol 14 (3) ◽  
pp. e239422
Author(s):  
Midori Tokushima ◽  
Masaki Tago ◽  
Naoko E Katsuki ◽  
Shu-ichi Yamashita
Keyword(s):  
B Cell ◽  
Cell Lymphoma ◽  
Histopathological Examination ◽  
B Cell Lymphoma ◽  
Final Diagnosis ◽  
Skin Lesions ◽  
Lower Abdomen ◽  
Large B Cell Lymphoma ◽  
Skin Induration ◽  
Large B Cell

A 75-year-old woman developed redness and swelling on her truncal skin, spreading from the lower abdomen to left thigh, 2 months before being admitted to our hospital. She was urgently hospitalised because of her worsening respiratory condition. On admission, she had reticular telangiectasia, diffuse skin induration on the lower abdomen and panhypopituitarism. She was diagnosed with intravascular large B-cell lymphoma (IVLBCL) by the third random abdominal skin biopsy. After histopathological examination at autopsy, we made a final diagnosis of IVLBCL causing respiratory failure and panhypopituitarism. This is the rare case of IVLBCL-induced panhypopituitarism showing visible skin lesions.

scholarly journals Hepatitis C Virus-Related Lymphomagenesis in a Mouse Model

2011 ◽  
Vol 2011 ◽  
pp. 1-8 ◽  
Author(s):  
Kyoko Tsukiyama-Kohara ◽  
Satoshi Sekiguchi ◽  
Yuri Kasama ◽  
Nagla Elwy Salem ◽  
Keigo Machida ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Mouse Model ◽  
B Cell ◽  
Lymphoproliferative Disorder ◽  
Interleukin 2 ◽  
Elevated Serum ◽  
Hcv Infection ◽  
Α Subunit ◽  
Non Hodgkin Lymphoma

B cell non-Hodgkin lymphoma is a typical extrahepatic manifestation frequently associated with hepatitis C virus (HCV) infection. The mechanism by which HCV infection leads to lymphoproliferative disorder remains unclear. Our group established HCV transgenic mice that expressed the full HCV genome in B cells (RzCD19Cre mice). We observed a 25.0% incidence of diffuse large B cell non-Hodgkin lymphomas (22.2% in male and 29.6% in female mice) within 600 days of birth. Interestingly, RzCD19Cre mice with substantially elevated serum-soluble interleukin-2 receptor α-subunit (sIL-2Rα) levels (>1000 pg/mL) developed B cell lymphomas. Another mouse model of lymphoproliferative disorder was established by persistent expression of HCV structural proteins through disruption of interferon regulatory factor-1 (irf-1_/_/CN2 mice). Irf-1_/_/CN2 mice showed extremely high incidences of lymphomas and lymphoproliferative disorders. Moreover, these mice showed increased levels of interleukin (IL)-2, IL-10, and Bcl-2 as well as increased Bcl-2 expression, which promoted oncogenic transformation of lymphocytes.

scholarly journals Orbital lymphoma associated with Graves’ disease: A case report

2014 ◽  
Vol 71 (5) ◽  
pp. 510-514 ◽  
Author(s):  
Zoran Hajdukovic ◽  
Snezana Kuzmic-Jankovic ◽  
Tamara Kljakovic-Avramovic ◽  
Leposava Sekulovic ◽  
Ljiljana Tukic
Keyword(s):  
Case Report ◽  
B Cell ◽  
Hodgkin Lymphoma ◽  
Marginal Zone ◽  
Radiation Treatment ◽  
Graves Disease ◽  
Decompression Surgery ◽  
Non Hodgkin Lymphoma ◽  
Graves Ophthalmopathy ◽  
Orbital Lymphoma

Introduction. The presence of bilateral exophthalmos and palpebral, periorbital edema associated with hyperthyroidism is most often considered as an initial sign of Graves? ophthalmopathy. However, in up to 20% of cases, Graves? ophthalmopathy might precede the occurrence of hyperthyroidism, which is very important to be considered in the differential diagnosis, especially if it is stated as unilateral. Among other less common causes of non-thyroid-related orbitopathy, orbital lymphoma represents rare conditions. We presented of a patient with Graves? disease, initially manifested as bilateral orbitopathy and progressive unilateral exophthalmos caused by the marginal zone B-cell non-Hodgkin lymphoma of the orbit. Case report. A 64-yearold man with the 3-year history of bilateral Graves? orbitopathy and hyperthyroidism underwent the left orbital decompression surgery due to the predominantly left, unilateral worsening of exophthalmos resistant to the previously applied glucocorticoid therapy. A year after the surgical treatment, a substantial exophthalmos of the left eye was again observed, signifying that other non-thyroid pathology could be involved. Orbital ultrasound was suggestive of primary orbital lymphoma, what was confirmed by orbital CT scan and the biopsy of the tumor tissue. Detailed examinations indicated that the marginal zone B-cell non-Hodgkin lymphoma extended to IV - B-b CS, IPI 3 (bone marrow infiltration: m+ orbit+). Upon the completion of the polychemiotherapy and the radiation treatment, a complete remission of the disease was achieved. Conclusion. Even when elements clearly indicate the presence of thyroid-related ophthalmopathy, disease deteriorating should raise a suspicion and always lead to imaging procedures to exclude malignancy.

A case of primary B-cell type Non-Hodgkin lymphoma originating in the iris

2003 ◽  
Vol 136 (2) ◽  
pp. 380-382 ◽  
Author(s):  
Kazuhiro Yamada ◽  
Akira Hirata ◽  
Akira Kimura ◽  
Hidenobu Tanihara
Keyword(s):  
B Cell ◽  
Hodgkin Lymphoma ◽  
Cell Type ◽  
Non Hodgkin Lymphoma

General case of the day. Secondary involvement of the breast with a non-Hodgkin lymphoma, B-cell type.

Radiographics ◽  
1992 ◽  
Vol 12 (3) ◽  
pp. 602-605 ◽  
Author(s):  
T Assaly ◽  
M J Palayew ◽  
A Lisbona ◽  
L Alpert
Keyword(s):  
B Cell ◽  
Hodgkin Lymphoma ◽  
Cell Type ◽  
Non Hodgkin Lymphoma

scholarly journals Translocations involving band 3q27 and Ig gene regions in non-Hodgkin's lymphoma [see comments]

Blood ◽  
1992 ◽  
Vol 79 (10) ◽  
pp. 2527-2531 ◽  
Author(s):  
C Bastard ◽  
H Tilly ◽  
B Lenormand ◽  
C Bigorgne ◽  
D Boulet ◽  
...  
Keyword(s):  
B Cell ◽  
Cytogenetic Analysis ◽  
Chromosomal Abnormalities ◽  
Large Cell ◽  
Cell Phenotype ◽  
Cell Type ◽  
Neoplastic Cells ◽  
Hodgkin's Lymphomas ◽  
Follicular Lymphomas ◽  
Chromosomal Defects

Abstract We report a series of 20 non-Hodgkin's lymphomas (NHL) in which cytogenetic analysis showed a translocation involving band 3q27 and the site of one of the three Ig genes (14q32, 2p12, 22q11) in the neoplastic cells. These cases were found in a series of 319 patients with clonal chromosomal abnormalities studied over a 7-year period. Fourteen patients had diffuse lymphoma, mainly of large cell type and the remaining six were follicular lymphomas. All cases studied were of B-cell phenotype. A t(3;14)(q27;q32) was commonest, found in 15 patients (4.7%), with the two variant translocations, t(3;22)(q27;q11) and t(2;3)(p12;q27), being found in three and two patients, respectively. Additional chromosomal defects were present in most patients, but two patients had this type of translocation as the sole abnormality. These results indicate that translocations involving band 3q27 and Ig genes are not uncommon, and suggest that a novel oncogene, located at band 3q27, may be implicated in B-cell NHL.

scholarly journals Clinicopathological Profile of Low-Grade B Cell Non-Hodgkin Lymphoma in Tertiary Health Care in West Java Indonesia

2020 ◽  
Vol 10 (6-s) ◽  
pp. 89-91
Author(s):  
Etis Primastari ◽  
Bethy Suryawathy Hernowo ◽  
Birgitta Maria Dewayani
Keyword(s):  
B Cell ◽  
Hodgkin Lymphoma ◽  
B Cell Lymphoma ◽  
Initial Therapy ◽  
Response To Therapy ◽  
Low Grade ◽  
Cell Type ◽  
Non Hodgkin Lymphoma ◽  
Clinicopathological Profile ◽  
Response Groups

Background: Low-grade B cell Non-Hodgkin lymphomas (NHL) are a group of lymphomas that are predominantly indolent and make up approximately 50% of all malignant lymphomas. Initial therapy for low-grade B cell LNH has an overall response rate of between 85-94% and a refractory rate of 6-10%. Few reports have been published regarding the clinicopathological characteristics of non-Hodgkin lymphoma cases, especially low-grade B cell types. This research aims to determine the clinicopathological profile of low-grade B cell type non-Hodgkin lymphoma cases. Method: This research is a descriptive study using cross-sectional methods. The sample consisted of 40 low-grade B cell type NHL cases from January 2015 to June 2020 at Hasan Sadikin Hospital, Bandung. Clinicopathological data, including age, sex, location of the tumor (nodal or extranodal), stage, B symptoms, and response to therapy, were taken from the patients’ medical records. Data were categorized into 2 groups based on response to initial therapy. Results and Discussion: Of the 40 cases diagnosed with low-grade B cell type NHL, 55% responded to initial therapy. From the non-response group, 61.1% were stage II and 72.2% exhibited B symptoms. There were no significant differences in age, sex, tumor location (nodal or extranodal), stage, or B symptoms in the response and non-response groups. Conclusion: In this study, 45% of patients with low-grade B cell type NHL did not respond to initial therapy. There was no statistically significant difference in the clinicopathological profiles of the response and non-response groups to initial therapy in cases of low-grade B cell type NHL. Keywords: Non-Hodgkin Lymphoma, low-grade B cell lymphoma, therapy response, clinicopathological

scholarly journals Translocations involving band 3q27 and Ig gene regions in non-Hodgkin's lymphoma [see comments]

Blood ◽  
1992 ◽  
Vol 79 (10) ◽  
pp. 2527-2531 ◽  
Author(s):  
C Bastard ◽  
H Tilly ◽  
B Lenormand ◽  
C Bigorgne ◽  
D Boulet ◽  
...  
Keyword(s):  
B Cell ◽  
Cytogenetic Analysis ◽  
Chromosomal Abnormalities ◽  
Large Cell ◽  
Cell Phenotype ◽  
Cell Type ◽  
Neoplastic Cells ◽  
Hodgkin's Lymphomas ◽  
Follicular Lymphomas ◽  
Chromosomal Defects

We report a series of 20 non-Hodgkin's lymphomas (NHL) in which cytogenetic analysis showed a translocation involving band 3q27 and the site of one of the three Ig genes (14q32, 2p12, 22q11) in the neoplastic cells. These cases were found in a series of 319 patients with clonal chromosomal abnormalities studied over a 7-year period. Fourteen patients had diffuse lymphoma, mainly of large cell type and the remaining six were follicular lymphomas. All cases studied were of B-cell phenotype. A t(3;14)(q27;q32) was commonest, found in 15 patients (4.7%), with the two variant translocations, t(3;22)(q27;q11) and t(2;3)(p12;q27), being found in three and two patients, respectively. Additional chromosomal defects were present in most patients, but two patients had this type of translocation as the sole abnormality. These results indicate that translocations involving band 3q27 and Ig genes are not uncommon, and suggest that a novel oncogene, located at band 3q27, may be implicated in B-cell NHL.

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