Oncologic Outcome of Stages II/III Colon Cancer Treated via Minilaparotomy

2011 ◽  
Vol 96 (2) ◽  
pp. 127-134 ◽  
Author(s):  
Hideyuki Ishida ◽  
Toru Ishiguro ◽  
Tomonori Ohsawa ◽  
Norimichi Okada ◽  
Kensuke Kumamoto ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Survival Data ◽  
Open Surgery ◽  
Survival Rates ◽  
Oncologic Outcome ◽  
Skin Incision ◽  
Consecutive Series ◽  
Minilaparotomy Approach ◽  
Conventional Open Surgery ◽  
Disease Free

Abstract We analyzed clinicopathologic, surgical, and survival data on consecutive series of patients with stages II/III colon cancer for whom curative resection via minilaparotomy (skin incision, ≤7 cm) was attempted between September 2002 and March 2009 to clarify the oncologic safety of this type of surgery. There were 64 men and 55 women; the median age was 70 years (range, 25–91 years). The median body mass index was 21.7 kg/m2 (range, 15.1–28.9 kg/m2). The minilaparotomy approach was successful in 115 cases (96.6%). The cumulative 5-year disease-free and overall survival rates were 89.7% and 82.4%, respectively, in patients with stage II disease (n  =  62) and were 68.4% and 82.4%, respectively, in patients with stage III disease (n  =  57), all of which were compatible with those of the historical control patients who underwent conventional open surgery. Minilaparotomy approach for stages II/III colon cancer seems to be oncologically equivalent to conventional open surgery.

scholarly journals Favorable short-term oncologic outcomes following laparoscopic surgery for small T4 colon cancer: a multicenter comparative study

2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Sung Sil Park ◽  
◽  
Joon Sang Lee ◽  
Hyoung-Chul Park ◽  
Sung Chan Park ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Laparoscopic Surgery ◽  
Open Surgery ◽  
Disease Free Survival ◽  
Laparoscopic Group ◽  
Oncologic Outcomes ◽  
Short Term ◽  
Free Survival ◽  
T4 Colon Cancer ◽  
Disease Free

Abstract Background Laparoscopic surgery for T4 colon cancer may be safe in selected patients. We hypothesized that small tumor size might preoperatively predict a good laparoscopic surgery outcome. Herein, we compared the clinicopathologic and oncologic outcomes of laparoscopic and open surgery in small T4 colon cancer. Methods In a retrospective multicenter study, we reviewed the data of 449 patients, including 117 patients with tumors ≤ 4.0 cm who underwent surgery for T4 colon cancer between January 2014 and December 2017. We compared the clinicopathologic and 3-year oncologic outcomes between the laparoscopic and open groups. Survival curves were estimated using the Kaplan–Meier method and compared using the log-rank test. Univariate and multivariate analyses were performed using the Cox proportional hazards model. A p < 0.05 was considered statistically significant. Results Blood loss, length of hospital stay, and postoperative morbidity were lower in the laparoscopic group than in the open group (median [range], 50 [0–700] vs. 100 [0–4000] mL, p < 0.001; 8 vs. 10 days, p < 0.001; and 18.0 vs. 29.5%, p = 0.005, respectively). There were no intergroup differences in 3-year overall survival or disease-free survival (86.6 vs. 83.2%, p = 0.180, and 71.7 vs. 75.1%, p = 0.720, respectively). Among patients with tumor size ≤ 4.0 cm, blood loss was significantly lower in the laparoscopic group than in the open group (median [range], 50 [0–530] vs. 50 [0–1000] mL, p = 0.003). Despite no statistical difference observed in the 3-year overall survival rate (83.3 vs. 78.7%, p = 0.538), the laparoscopic group had a significantly higher 3-year disease-free survival rate (79.2 vs. 53.2%, p = 0.012). Conclusions Laparoscopic surgery showed similar outcomes to open surgery in T4 colon cancer patients and may have favorable short-term oncologic outcomes in patients with tumors ≤ 4.0 cm.

scholarly journals Endo-laparoscopic approach versus conventional open surgery in the treatment of obstructing left-sided colon cancer: Long-term follow-up of a randomized trial

2013 ◽  
Vol 6 (2) ◽  
pp. 78-81 ◽  
Author(s):  
Karen Lok Man Tung ◽  
Hester Yui Shan Cheung ◽  
Lawrence Wing Chiu Ng ◽  
Cliff Chi Chiu Chung ◽  
Michael Ka Wah Li
Keyword(s):  
Colon Cancer ◽  
Randomized Trial ◽  
Open Surgery ◽  
Laparoscopic Approach ◽  
Long Term Follow Up ◽  
Conventional Open Surgery

scholarly journals Hand-assisted laparoscopic versus open surgery for radical gastrectomy in the treatment of advanced distal gastric cancer: long-term overall and disease-free survival (final results of a single-center study)

2021 ◽  
Vol 49 (9) ◽  
pp. 030006052110477
Author(s):  
Guode Luo ◽  
Xiaohua Wang ◽  
Yajiao Li ◽  
Guangyu Chen ◽  
Yongkuan Cao ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Overall Survival ◽  
Open Surgery ◽  
Survival Rates ◽  
Disease Free Survival ◽  
Radical Gastrectomy ◽  
Free Survival ◽  
Distal Gastric Cancer ◽  
Disease Free

Objective To compare the surgical effects and long-term efficacy of hand-assisted laparoscopic surgery (HALS) and open surgery (OS) in radical gastrectomy for advanced distal gastric cancer. Methods One hundred twenty-four patients who were admitted to the Department of Gastrointestinal Surgery of the West War Zone General Hospital from May 2008 to April 2012 were randomly divided into a HALS group (n = 62) and an OS group (n = 62). After surgery, 113 patients were followed up for 5 and 8 years, and 11 patients were lost to follow-up. The 5- and 8-year overall survival and disease-free survival rates of the two groups were compared and analyzed. Results The 5- and 8-year overall survival rates were 31.90% and 18.40% in the HALS group and 32.50% and 18.60% in the OS group, respectively. The 5- and 8-year disease-free survival rates were 21.50% and 13.00% in the HALS group and 21.90% and 13.10% in the OS group, respectively. No significant differences were found. Conclusion Hand-assisted laparoscopic radical gastrectomy for advanced distal gastric cancer has the advantages of less severe trauma, less intraoperative blood loss, more rapid postoperative recovery, and equivalent long-term efficacy compared with OS.

Curative Resection of Transverse Colon Cancer via Minilaparotomy

2011 ◽  
Vol 96 (1) ◽  
pp. 6-12 ◽  
Author(s):  
Hideyuki Ishida ◽  
Tohru Ishiguro ◽  
Keiichiro Ishibashi ◽  
Tomonori Ohsawa ◽  
Norimichi Okada ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Sigmoid Colon ◽  
Transverse Colon ◽  
Curative Resection ◽  
Disease Free Survival ◽  
Oncologic Outcome ◽  
Skin Incision ◽  
Sigmoid Colon Cancer ◽  
Transverse Colon Cancer ◽  
Disease Free Survival Rate

Abstract Minilaparotomy has been reported to be a minimally invasive alternative to laparoscopically assisted surgery. We retrospectively evaluated the usefulness of minilaparotomy for the resection of transverse colon cancer, which has generally been considered difficult to resect laparoscopically. Patients for whom curative resection was attempted for transverse colon cancer (n  =  21) or sigmoid colon cancer (n  =  81) via minilaparotomy (skin incision, ≤ 7cm) were analyzed. The 2 groups did not significantly differ in terms of success rate of minilaparotomy (90.5% versus 97.5%), age, sex, pathologic stage, body mass index, operative time (mean, 133.5 minutes versus 122.5 minutes), blood loss (119.7 mL versus 92.4 mL), number of lymph nodes harvested, incidence of postoperative complications (9.5% versus 12.3%), postoperative length of stay, and 5-year disease-free survival rate (86.6% versus 79.6%). Minilaparotomy is feasible, safe, and favorable in terms of early oncologic outcome in patients with transverse colon cancer as well as those with sigmoid colon cancer.

scholarly journals Laparoscopic Wide Mesocolic Excision and Central Vascular Ligation for Carcinoma of the Colon

2016 ◽  
Vol 105 (4) ◽  
pp. 228-234 ◽  
Author(s):  
A. Ehrlich ◽  
M. Kairaluoma ◽  
J. Böhm ◽  
K. Vasala ◽  
H. Kautiainen ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Disease Free Survival ◽  
Oncologic Outcome ◽  
Complete Mesocolic Excision ◽  
Central Vascular Ligation ◽  
Free Survival ◽  
Carcinoma Of The Colon ◽  
Vascular Ligation ◽  
Mesocolic Excision ◽  
Disease Free

Background and Aims: The principle of complete mesocolic excision for colon cancer has been introduced to improve oncologic outcome. However, this approach is scantily discussed for laparoscopic surgery and there is a lack of randomized trials. This study examined oncologic and clinical outcome after laparoscopic wide mesocolic excision and central vascular ligation for colon cancer. Material and Methods: This is a review of prospectively gathered data from a single-institution colorectal cancer database. This study was conducted in the Central Hospital of Central Finland. From January 2003 to December 2011, 222 patients underwent laparoscopic colonic resections with wide mesocolic excision and central vascular ligation in the multimodal setting. The main measures of outcome were cancer recurrence and survival, with early recovery, 30d-mortality and morbidity, reoperation, readmission, and late complications as secondary outcomes. Results: The median follow-up was 5.5 (interquartile range (IQR) = 3.7–8.0) years. The 5-year overall survival for all 222 patients was 80.2% and disease-specific survival was 87.5%, and for those 210 R0-patients with stage I–III disease, 83.9% and 91.3%, respectively. The 5-year disease-free survival was 85.8%: stage I was 94.7%, stage II was 90.8%, and stage III was 75.6% ( p = 0.004). Increasing lymph node ratio significantly decreased the 5-year disease-free survival. Conversion rate to open surgery was 12.2%. Thirty-day mortality was 1.3% and morbidity, 19.7%. Median postoperative hospital stay was 5 (IQR = 3–7) days. Conclusion: Laparoscopic wide mesocolic excision and central vascular ligation for colon cancer resulted in good long-term oncologic outcome. Randomized trials are needed to show that laparoscopic complete mesocolic excision technique would become the standard of care for the carcinoma of the colon.

Conditional survival for patients with colon cancer: An analysis of National Surgical Adjuvant Breast and Bowel Project (NSABP) trials C-03 through C-06

2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 6005-6005 ◽  
Author(s):  
S. J. Wang ◽  
B. A. Zamboni ◽  
H. S. Wieand ◽  
G. Yothers ◽  
J. J. Dignam ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Survival Data ◽  
Survival Probability ◽  
Performance Status ◽  
Disease Free Survival ◽  
Time Interval ◽  
Conditional Survival ◽  
Survival Times ◽  
Prognostic Information ◽  
Disease Free

6005 Background: Survival for cancer patients is usually only reported as survival from time of diagnosis to some time landmark (e.g., 5 yrs). For pts surviving one or more years after diagnosis, however, their survival probability changes, and is more accurately depicted by conditional survival (CS), defined as the probability of surviving for an additional fixed time interval given that the pt has already survived a period of time. The purpose of this study was to determine the 5-yr CS of colon cancer pts in 4 NSABP trials. Methods: We analyzed long-term overall survival data from the 5587 colon cancer pts who were enrolled in fluorouracil (or equivalent) arms of NSABP trials C-03 through C-06. We computed observed 5-yr overall CS for pts who had already survived without disease from 0 to 5 yrs after diagnosis, and stratified the results by age, sex, race, stage, number of positive nodes, number of nodes resected, tumor location, and performance status. Results: The Table below shows the 5-yr overall CS for all pts and for selected subgroups for different survival times since diagnosis. As disease-free survival time since diagnosis increased, 5-yr observed overall CS increased from 76% to 90% at 5 yrs. For pts under age 50, CS increased from 78% to 95% at 5 yrs, but for pts > 70 yrs, CS remained fairly constant (71–82%). For pts with > 10 positive nodes, CS increased from 37% to 81% at 5 yrs, but did not change appreciably for node-negative pts (87–92%). Dukes’ C pts saw an increase in CS from 68% to 88% at 5 yrs, while CS for Dukes’ B pts did not change appreciably. Conclusion: Projected survival probability generally increases with time for colon cancer pts who remain disease-free for a period of time after diagnosis, and conditional survival can provide more informative prognostic information for these pts. An additional effect is that prognostic factors that are important at baseline become less important for conditional survival as the disease-free period increases. [Table: see text] No significant financial relationships to disclose.

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