scholarly journals Solitary Hepatic Eosinophilic Granuloma Accompanied by Eosinophilia Without Parasitosis: Report of a Case

2015 ◽  
Vol 100 (6) ◽  
pp. 1011-1017 ◽  
Author(s):  
Takatsugu Yamamoto ◽  
Toru Miyazaki ◽  
Yukiko Kurashima ◽  
Kazunori Ohata ◽  
Masato Okawa ◽  
...  
Keyword(s):  
Intestinal Tract ◽  
Immunoglobulin E ◽  
Histopathological Examination ◽  
Past History ◽  
Eosinophilic Granuloma ◽  
Japanese Woman ◽  
Larva Migrans ◽  
Enzyme Linked Immunosorbent Assay ◽  
Type I ◽  
Old Japanese

A 43-year-old Japanese woman visited for a hepatic tumor incidentally found. We suspected eosinophilic granuloma of the liver (EGL) due to visceral larva migrans (VLM). However, neither past history nor medical interview indicated a risk of parasitosis. Blood testing revealed eosinophilia, serum examination showed normal results for immunoglobulin E, and enzyme-linked immunosorbent assay yielded negative for Toxocara and Anisakis. Gastric and colonic endoscopy revealed normal features. Several imagings showed central necrosis of the tumor. After informed consent, laparoscopic resection was performed. Histopathological examination showed EGL without parasites. No recurrence had occurred postoperatively. Most reports documented that EGL are caused by VLM. However, parasites are not always demonstrable on serum, histopathological, or immunochemical examinations. When acting as allergens to induce type I responses, microscopic agents other than parasites in the intestinal tract could induce eosinophilic inflammation in the liver. Accumulation of more cases should help clarify other pathogeneses for EGL.

scholarly journals Neuroendocrine carcinoma arising in a wound of the postoperative maxillary sinus

2012 ◽  
Vol 2 (1) ◽  
pp. 16
Author(s):  
Takeshi Kusunoki ◽  
Katsuhisa Ikeda
Keyword(s):  
Maxillary Sinus ◽  
Neuroendocrine Carcinoma ◽  
Past History ◽  
Japanese Woman ◽  
Old Japanese ◽  
Weighted Magnetic Resonance Imaging ◽  
Maxillary Cyst ◽  
Left Maxillary Sinus ◽  
Eye Movement Disorders ◽  
Cheek Swelling

We report a case of a neuroendocrine carcinoma arising in a wound of the postoperative maxillary sinus that was difficult to distinguish from a postoperative maxillary cyst. The patient was a 65-year-old Japanese woman who complained of left exophthalmos with cheek swelling and eye movement disorders. In past history, she had, 40 years previously undergone operation on the bilateral maxillary sinus by Caldwell-Luc’s method. In a preoperative computed tomography, a mass occupied the left maxillary sinus showing irregular densities with destruction of the posterior bone walls and invasion into the left orbital. Both TI and T2 weighted magnetic resonance imaging showed low intensities and unevenness in the mass. We performed a biopsy of the maxillary tumor according to Caldwell-Luc’s method. Histological examination diagnosed neuroendocrine carcinoma. Radiation therapy (total 66Gy) resulted in partial response for this tumor. However, sinonasal neuroendocrine carcinoma has been identified as highly aggressive, with a high probability of recurrence and metastasis.

scholarly journals Eosinophilic Fasciitis Associated with Myositis

2015 ◽  
Vol 7 (1) ◽  
pp. 79-83 ◽  
Author(s):  
Yuko Adachi ◽  
Yoko Mizutani ◽  
En Shu ◽  
Hiroyuki Kanoh ◽  
Tatsuhiko Miyazaki ◽  
...  
Keyword(s):  
Histopathological Examination ◽  
Lymphocytic Infiltration ◽  
Japanese Woman ◽  
Eosinophilic Fasciitis ◽  
Old Japanese ◽  
Weighted Magnetic Resonance Imaging ◽  
Peau D’Orange ◽  
Lymphocytic Infiltrates ◽  
Immunohistological Study ◽  
Fibrinoid Degeneration

Eosinophilic fasciitis is clinically characterized by symmetrical scleroderma-like indurations of the skin with pain. The histological features are fascial inflammation with lymphocytes and eosinophils as well as thickened and fibrotic fascia. Lymphocytic infiltration and degeneration of the underlying muscle are rarely observed. We report a 69-year-old Japanese woman who presented with multiple areas of glossy induration and painful peau d'orange-like lesions on the chest and four extremities. T2-weighted magnetic resonance imaging showed significant hyperintense thickening of the fascia of the lower extremities. Histopathological examination of a biopsy specimen from the induration showed marked fibrinoid degeneration of the fascia and the neighboring muscle with mixed cellular infiltration of lymphocytes and eosinophils. The predominant CD8+ lymphocytic infiltrates were observed by immunohistological study. A diagnosis of eosinophilic fasciitis with myositis was made. Oral administration of prednisolone and discontinuation of exercise significantly improved the lesions and pain.

scholarly journals Successful management of cutaneous lymphangitis carcinomatosa arising from cervical cancer with paclitaxel-cisplatin and bevacizumab combination therapy: a case report and review of the literature

2019 ◽  
Vol 13 (1) ◽  
Author(s):  
Fumihiro Nakamura ◽  
Manabu Seino ◽  
Yuriko Suzuki ◽  
Hirotsugu Sakaki ◽  
Takeshi Sudo ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Combination Therapy ◽  
Histopathological Examination ◽  
Therapeutic Option ◽  
Japanese Woman ◽  
Positron Emission ◽  
Curative Radiotherapy ◽  
Old Japanese ◽  
Effective Therapeutic Option ◽  
Lymphangitis Carcinomatosa

Abstract Background Globally, cervical cancer is the fourth most common cancer in women. Here, we report a case of cutaneous lymphangitis carcinomatosa arising from cervical cancer, an extremely rare and treatment-resistant condition. Case presentation A 64-year-old Japanese woman presented with genital bleeding. She was diagnosed as having stage IB1 squamous cell cervical cancer and subsequently treated with radiotherapy. Approximately 2 years after the curative radiotherapy, she developed itching, skin rash, and small nodules on her left femoral and pubic area. Slight 18F-fluorodeoxyglucose uptake was detected at her left femoral skin on positron emission tomography with computed tomography. A histopathological examination was performed on a biopsy sample from an erythematous macule on her left femoral skin and vulva. Consequently, she was diagnosed as having cutaneous lymphangitis carcinomatosa arising from cervical cancer. Paclitaxel (135 mg/m2), cisplatin (50 mg/m2), and bevacizumab (15 mg/kg) combination therapy was administered every 21 days. Both itching and rash improved after three treatment cycles. After the completion of six cycles, skin erythema in the femoral and vulval area disappeared completely. Our patient experienced a 25-month symptom-free interval after the last chemotherapy session. Conclusion Our findings suggest that combination chemotherapy plus bevacizumab is an effective therapeutic option in patients with cutaneous lymphangitis carcinomatosa arising from cervical cancer.

Cerebellitis in a human T-lymphotropic virus type 1 carrier: a case report

2021 ◽  
Vol 14 (6) ◽  
pp. e241366
Author(s):  
Atsushi Mizuma ◽  
Kumiko Enokida ◽  
Eiichiro Nagata ◽  
Shunya Takizawa
Keyword(s):  
Cerebrospinal Fluid ◽  
Virus Type ◽  
Spastic Paraparesis ◽  
Saccadic Eye Movements ◽  
Japanese Woman ◽  
High Dose ◽  
Type I ◽  
T Lymphotropic Virus ◽  
Word Finding ◽  
Old Japanese

Human T-lymphotropic virus type I (HTLV-I) is a retrovirus associated with adult T-cell lymphoma (ATL) and HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP). In addition to HAM/TSP and ATL, HTLV-I-associated encephalopathy and cerebellar involvement have been reported. We report a case of an 87-year-old Japanese woman presenting with progressive dysarthria and gait disturbance. Neurological examination showed word-finding difficulty, scanning speech, saccadic eye movements, ocular dysmetria, gaze-evoked nystagmus and bilateral dysmetria. There was no motor weakness or spasticity. HTLV-I antibody was detected in both her serum and cerebrospinal fluid. Cerebrospinal fluid neopterin (57 pg/mL) and IgG index (3.27) were significantly elevated. MRI showed cerebellar swelling. She was finally diagnosed with HTLV-I associated cerebellitis. Two courses of high-dose intravenous methylpredonine therapy attenuated cerebellar ataxia and cerebellar swelling. It suggests that cerebellitis can result from HTLV-I infection, regardless of the existence of ATL or HAM/TSP.

scholarly journals Tearfilm immunoglobulin E (IgE) level in vernal keratoconjunctivitis by ELISA

1970 ◽  
Vol 7 (2) ◽  
pp. 104-108 ◽  
Author(s):  
S Pokharel ◽  
DN Shah ◽  
SN Joshi ◽  
M Choudhary
Keyword(s):  
Hypersensitivity Reaction ◽  
Immunoglobulin E ◽  
Vernal Keratoconjunctivitis ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Female Group ◽  
Type I ◽  
High Concentration ◽  
Type Iv ◽  
Significant Difference

Background: Vernal keratoconjunctivitis (VKC) is recurrent chronic allergic conjunctivitis occurring in the prepubertal age-group with secondary involvement of the cornea and is self-limiting in character. The disease is prevalent worldwide but it shows predominance in the areas with dry and warm climate including the South Asia. VKC represents about 3% of the serious ophthalmic disease in some parts of the world where the prevalence is rate is high.Type I hypersensitivity reaction which is IgE-dependent and type IV hypersensitivity reaction have been implicated for the pathogenesis VKC. Objective: To determine level of immunoglobulin E (IgE) in the tear film of patients with Vernal Keratoconjunctivitis (VKC) attending outpatient department of BP Koirala Lions Centre for Ophthalmic Studies (BPKLCOS). Materials and methods: Thirty-four VKC patients and thirty-four controls were included in this study. Tear samples were collected using micro- capillary glass tube method and tear IgE levels were measured using an enzyme - linked immunosorbent assay (ELISA). Results: There was high concentration of tear IgE level in VKC (95.09IU/ml) than in controls (1.63IU/ml) though the difference was not statistically significant (p=0.16). No statistically significant difference was observed in male and female gender within VKC group and when compared with control group (in male group, p=0.21 and in female group, p=0.26). There was no statistically significant difference observed in tear IgE level in different age groups within VKC group and when compared with control group (p=0.30). The result did not show any significant difference in tear IgE level with respect to the duration of the disease (p=0.23).There was no statistically significant difference in tear IgE level with different episodes of VKC (p=0.69). No statistically significant difference of IgE concentration in tear was seen among different types of VKC (p=0.53) and grades of tarsal and limbal papillae (p= 0.72). Conclusion: There was high concentration of tear IgE level observed in VKC. Key words: Vernal keratoconjunctivitis; Tearfilm; IgE level; Type I hypersensitivity reaction; Type IV hypersensitivity reaction. DOI: 10.3126/kumj.v7i2.2700 Kathmandu University Medical Journal (2009) Vol.7, No.2 Issue 26, 104-108

Macromolecular transport by rat gastric mucosa

1992 ◽  
Vol 262 (6) ◽  
pp. G1033-G1040 ◽  
Author(s):  
G. H. Curtis ◽  
D. G. Gall
Keyword(s):  
Gastric Mucosa ◽  
Immunoglobulin E ◽  
Intact Protein ◽  
Enzyme Linked Immunosorbent Assay ◽  
Metabolic Inhibitor ◽  
Type I ◽  
Protein Antigens ◽  
Atp Production ◽  
Ussing Chambers ◽  
Rat Gastric Mucosa

We previously demonstrated that the stomach is capable of mounting a type I hypersensitivity reaction to luminal antigen challenge. These findings imply that antigenically intact macromolecules cross the gastric mucosa. To test this hypothesis, rat gastric mucosa was mounted in Ussing chambers, and bovine serum albumin (BSA, 0.5 mg/ml) and 125I-labeled BSA (10 microCi) were added to mucosal fluids. After equilibration, serosal fluids were sampled for two 30-min periods, and fluxes of immunologically intact BSA (determined by an enzyme-linked immunosorbent assay) and total BSA (125I-BSA) were calculated under basal conditions and in the presence of NaF and colchicine, and at 4 degrees C. Additional experiments examined macromolecular permeability in sensitized-challenged tissues. Immunologically intact BSA (21.3 +/- 4.5 ng.30 min-1.cm-2) crossed the gastric mucosa as approximately one-fourth of the total BSA flux (78.2 +/- 7.5 ng.30 min-1.cm-2). The uptake of immunologically intact BSA was significantly reduced by NaF, an inhibitor of ATP production and endocytosis; colchicine, which inhibits polymerization of cytoskeletal microtubules; and at 4 degrees C, a general metabolic inhibitor. The transmural passage of antigen was not significantly altered by immunoglobulin E-mediated anaphylaxis. These findings indicate that intact protein antigens cross the gastric mucosa by an active, energy-dependent mechanism that uses the microtubular network.

Granular cell tumour arising from the Kiesselbach's area of the nasal septum

2006 ◽  
Vol 121 (2) ◽  
pp. 170-173 ◽  
Author(s):  
T Sasaki ◽  
K Yamamoto ◽  
T Akashi
Keyword(s):  
Nasal Septum ◽  
Histopathological Examination ◽  
English Literature ◽  
Granular Cell ◽  
Surgical Excision ◽  
Japanese Woman ◽  
Cell Tumour ◽  
Granular Cell Tumour ◽  
Old Japanese ◽  
The Right

An extremely rare case of a granular cell tumour arising from the right Kiesselbach's area (Little's area) of the nasal septum is reported. A 69-year-old Japanese woman consulted our clinic and her chief complaints were of continuous serous discharge, stuffiness and occasional slight bleeding from the right nasal cavity. Fibrescopy showed a multilocular mass, which was provisionally considered a nasal polyp. Surgical excision was attempted. During surgery, the tumour shrank markedly following local application of adrenaline, suggestive of hypervascularity. The tumour was successfully excised by careful dissection after cauterisation of the mucosa surrounding the tumour. Histopathological examination revealed morphological features of granular cell tumour immunopositive for S-100 protein. This is the first report of granular cell tumour arising from the Kiesselbach's area in the English literature. The eccentric behaviour of the tumour and the management of a granular cell tumour arising from this area are discussed, together with a literature review.

Eosinophilic granuloma of gastro-intestinal tract Larva migrans

1969 ◽  
Vol 4 (4) ◽  
pp. 323-323
Author(s):  
K. Tsushima ◽  
N. Yamagata ◽  
N. Aoki ◽  
H. Tsuchida ◽  
T. Mikami ◽  
...  
Keyword(s):  
Intestinal Tract ◽  
Eosinophilic Granuloma ◽  
Larva Migrans ◽  
Gastro Intestinal Tract

Tonsillar lipoma: a case report

1995 ◽  
Vol 109 (7) ◽  
pp. 662-664 ◽  
Author(s):  
Hiroshi Harada ◽  
Shoichi Kashiwagi ◽  
Minoru Morimatsu ◽  
Tadamitsu Kameyama ◽  
Masami Takahashi
Keyword(s):  
Case Report ◽  
Connective Tissue ◽  
Histopathological Examination ◽  
Fibrous Tissue ◽  
Japanese Woman ◽  
Fibrous Connective Tissue ◽  
Fat Tissue ◽  
Mucosal Epithelium ◽  
Old Japanese ◽  
Benign Tumours

AbstractBenign tumours of the tonsils are rare. Only a few cases of tonsillar lipoma have been previously reported. The case of a pedunculated polypoid lipoma of the palatine tonsil in a 44-year-old Japanese woman is presented. The ‘polyp’ was excised and an histopathological examination was carried out. The ‘polyp’ contained dilated lymphatics in the dense fibrous connective tissue beneath the overlying mucosal epithelium and below the mature fat tissue with intervening strands of fibrous tissue.

scholarly journals ORAL ALLERGY SYNDROME (OAS) AKIBAT REAKSI ALERGI MAKANAN

2018 ◽  
Vol 2 (2) ◽  
pp. 125-132
Author(s):  
Nanan Nur'aeny
Keyword(s):  
Fruits And Vegetables ◽  
Immunoglobulin E ◽  
Signs And Symptoms ◽  
Basophil Activation Test ◽  
Specific Ige ◽  
Oral Allergy Syndrome ◽  
Enzyme Linked Immunosorbent Assay ◽  
Type I ◽  
Prick Test ◽  
Bet V 1

Allergic condition such as itching of the skin, or runny nose and sneezing are widely known, but different case of allergic reaction in the mouth. Are still unknown, one of them is Oral Allergy Syndrome (OAS). Almost everyone knows food allergens such as shrimp, or marine fish, but actually fresh fruits and vegetables also can trigger allergic reactions like OAS in the form of itching or swelling of the lips, tongue, palate, and pharynx. Author intends to provide further information about the OAS in this paper. The mechanism of OAS is a type I, immunoglobulin E-mediated hypersensitivity reaction, common in atopic people with history of atopic rhinitis, bronchial asthma, or urticaria. Food allergen that causes OAS have a cross reaction/ homolog with pollen from protein pathogen respons / PR-10 family, such as Bet v 1 (Birch) and Bet v 2 (Birch). Some OAS allergens from vegetables that homolog with Bet v 1 includes celery (Api g 1) and soybean (Gly m 4), and other allergens from fruits homolog with Bet v 2, such as Ana c1 alergen pineapple. The diagnosis of OAS based on medical history, clinical examination and diagnostic tests includes skin prick test, specific IgE serum, or basophil activation test, and cellular antigen stimulation test with an enzyme-linked immunosorbent assay. Management of OAS consists of non-pharmacological includes information and education to avoid the causes, and give suggestion to eat cooked food. Pharmacologically are prescription of antihistamines or epinephrine injection in case of emergencies. Signs and symptoms of OAS in fact have long been found, but its diagnosis and management are still not widely known. Dentist should know about signs and symptoms of food allergy in the oral mucosa include OAS which caused by fruits and vegetables such as celery, soybean, carrot, apple, pineapple, and strawberry, so finally dentist will provide good management for the patient..

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