ORAL ALLERGY SYNDROME (OAS) AKIBAT REAKSI ALERGI MAKANAN

Allergic condition such as itching of the skin, or runny nose and sneezing are widely known, but different case of allergic reaction in the mouth. Are still unknown, one of them is Oral Allergy Syndrome (OAS). Almost everyone knows food allergens such as shrimp, or marine fish, but actually fresh fruits and vegetables also can trigger allergic reactions like OAS in the form of itching or swelling of the lips, tongue, palate, and pharynx. Author intends to provide further information about the OAS in this paper. The mechanism of OAS is a type I, immunoglobulin E-mediated hypersensitivity reaction, common in atopic people with history of atopic rhinitis, bronchial asthma, or urticaria. Food allergen that causes OAS have a cross reaction/ homolog with pollen from protein pathogen respons / PR-10 family, such as Bet v 1 (Birch) and Bet v 2 (Birch). Some OAS allergens from vegetables that homolog with Bet v 1 includes celery (Api g 1) and soybean (Gly m 4), and other allergens from fruits homolog with Bet v 2, such as Ana c1 alergen pineapple. The diagnosis of OAS based on medical history, clinical examination and diagnostic tests includes skin prick test, specific IgE serum, or basophil activation test, and cellular antigen stimulation test with an enzyme-linked immunosorbent assay. Management of OAS consists of non-pharmacological includes information and education to avoid the causes, and give suggestion to eat cooked food. Pharmacologically are prescription of antihistamines or epinephrine injection in case of emergencies. Signs and symptoms of OAS in fact have long been found, but its diagnosis and management are still not widely known. Dentist should know about signs and symptoms of food allergy in the oral mucosa include OAS which caused by fruits and vegetables such as celery, soybean, carrot, apple, pineapple, and strawberry, so finally dentist will provide good management for the patient..

Download Full-text

Birch pollen associated soy allergy – possibilities in diagnostic and clinical relevance1)

LaboratoriumsMedizin ◽

10.1515/labmed-2012-0019.et ◽

2012 ◽

Vol 36 (3) ◽

Author(s):

Susanne Beyer ◽

Ulrich Sack ◽

Regina Treudler

Keyword(s):

Birch Pollen ◽

Basophil Activation Test ◽

Specific Ige ◽

Oral Allergy Syndrome ◽

Food Allergies ◽

Food Allergens ◽

Prick Test ◽

The Past ◽

Immunological Cross Reaction

AbstractBirch pollen allergic individuals frequently suffer from food allergies in the form of an oral allergy syndrome after eating pome and stone fruits. These complaints are based on an immunological cross-reaction between pollen and food allergens. In the past, it has been shown that many birch pollen allergic patients are additionally not able to tolerate high protein soy products. Some severe immediate type reactions to soy have been observed. The cause for these immediate type reactions to soy is a Bet v 1 cross-reactive soy allergen called Gly m 4.Using a collective of 73 birch pollen allergic patients with associated food allergy in Leipzig as an example, the results of a standardized questioning, prick-to-prick test with a soy drink, determination of specific IgE against rGly m 4, and basophil activation test with Gly m 4 are presented.We showed that commercially available prick test extracts and determination of specific IgE against soy bean mix/f14 are not appropriate to diagnose birch pollen associated soy allergy. Generally, soy sensitization could be proven when a prick-to-prick-test with a soy drink and determination of specific IgE against rGly m 4 were done. A positive prick-to-prick test with a soy drink was found in 79% (55/70) of the birch pollen allergic patients with 89% (65/73) showing specific IgE for rGly m 4 (CAP>1). Although not every sensitization was clinically relevant, every third patient with a proven soy sensitization was diagnosed with a clinically relevant allergy to soy.

Download Full-text

Allergic Response

10.2310/fm.1232 ◽

2019 ◽

Author(s):

Joud Hajjar ◽

Lawrence B Schwartz

Keyword(s):

Mast Cell ◽

Immunoglobulin E ◽

Signs And Symptoms ◽

Specific Ige ◽

Consensus Conference ◽

Allergic Response ◽

Working Definition ◽

Keywords Allergy ◽

Ige Mediated ◽

Definition Of

The term hypersensitivity refers to diseases caused by an immune response, regardless of whether the response is against a pathogen, nonpathogen, or self and regardless of whether the response is directed by antibodies, lymphocytes, or innate pathways. The term anaphylaxis was coined in 1902 by Charles Richet, who received the Nobel Prize in 1913; this systemic allergic response is now known to be an immediate hypersensitivity reaction, initiated by allergen delivered to a host having allergen-specific IgE, thereby causing an IgE-mediated immunologic response and activating mast cells and basophils to secrete bioactive mediators. In 2005, the National Institutes of Health organized a consensus conference to develop a working definition of anaphylaxis, designed to be used by physicians at the bedside, as a serious allergic reaction that is rapid in onset, typically eliciting various combinations of cutaneous, cardiovascular, respiratory, and gastrointestinal manifestations, and may cause death.1,2 This facilitated the early treatment of such patients with epinephrine. Confusion arises over the misapplication of the term allergy or hypersensitivity to describe any untoward reaction to food, medications, or environmental exposures. Furthermore, non–IgE-mediated forms of local and systemic mast cell or basophil activation events can occur, causing signs and symptoms similar to those mediated by IgE. This review contains 3 figures, 9 tables, and 62 references. Keywords: allergy, hypersensitivity, anaphylaxis, interleukin, chemokines, immunoglobulin E, mast cell, eosinophil

Download Full-text

Allergenic Characterization of Tropomyosin from the Dusky Brown Cockroach, Periplaneta fuliginosa

Clinical and Diagnostic Laboratory Immunology ◽

10.1128/cdli.11.4.680-685.2004 ◽

2004 ◽

Vol 11 (4) ◽

pp. 680-685 ◽

Cited By ~ 12

Author(s):

Kyoung Yong Jeong ◽

Heeyu Hwang ◽

Jongweon Lee ◽

In-Yong Lee ◽

Dong Soo Kim ◽

...

Keyword(s):

Recombinant Protein ◽

Periplaneta Americana ◽

Immunoglobulin E ◽

Expression System ◽

Specific Ige ◽

Cross Reactivity ◽

Enzyme Linked Immunosorbent Assay ◽

Inhibitor Concentration ◽

The Cross ◽

Elisa Inhibition

ABSTRACTHousehold arthropods are one of the most common causes of allergic diseases. Four species of cockroaches are found to reside in Korean homes, but published work deals almost exclusively with the German and American cockroaches. This study was undertaken to investigate the cross-reactive allergenic components of the dusky brown cockroach,Periplaneta fuliginosa. Enzyme-linked immunosorbent assay (ELISA) inhibition and immunoblot analyses for the dusky brown cockroach were performed withBlattella germanicaandDermatophagoides farinaeallergic sera. cDNA encoding tropomyosin, which is a well known cross-reactive pan-allergen, was cloned by reverse transcriptase PCR, and recombinant protein was produced by using a pET-28b expression system. Native tropomyosin was purified by ammonium sulfate fractionation and electroelution. The immunoglobulin E (IgE) reactivities of native and recombinant tropomyosins were compared by an ELISA inhibition study. All 30 sera tested showedP. fuliginosa-specific IgE, and the IgE-binding reactivity of theP. fuliginosaextract was inhibited as much as 79.4% by aB. germanicaextract and as much as 63.3% by aD. farinaeextract. The deduced amino acid sequence of cloned cDNA was identical with that ofPeriplaneta americanatropomyosin (98.5% nucleotide sequence identity). Seven of 26 (26.9%) allergic sera had IgE specific for recombinant protein, and the maximum inhibition ofP. fuliginosa-specific IgE achieved with recombinant tropomyosin was 37.7% at an inhibitor concentration of 10 μg/ml. Native tropomyosin inhibited the binding of IgE to theP. fuliginosa,B. germanica, andD. farinaeextracts by 65.0, 51.8, and 39% at an inhibitor concentration of 1 μg/ml.P. fuliginosaappears to possess allergens that are highly cross-reactive with allergens ofB. germanicaandD. farinae. Tropomyosin was found to be a major allergenic component accounting for the cross-reactivity between cockroaches and dust mites.

Download Full-text

KAITAN IgE SPESIFIK METODE IMUNOBLOT TERHADAP ELISA PADA RINITIS ALERGI (Association Between Specific IgE Immunoblot Method with ELISA on Allergic Rhinitis)

INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY ◽

10.24293/ijcpml.v21i3.1284 ◽

2018 ◽

Vol 21 (3) ◽

pp. 298

Author(s):

Aryati Aryati ◽

Dwi Retno Pawarti ◽

Izzuki Muhashonah ◽

Janti Tri Habsari

Keyword(s):

Allergic Rhinitis ◽

Correlation Coefficient ◽

Sensitivity And Specificity ◽

Clinical Signs ◽

Signs And Symptoms ◽

Specific Ige ◽

Total Serum ◽

Inhalant Allergen ◽

Elisa Method ◽

Prick Test

Allergic rhinitis is an allergic disease that is most often found beside bronchial asthma and eczema with the prevalence of is about33.3%, 9.8% and 11.2% respectively. The main examinations of allergic rhinitis are Skin Prick Test (SPT) and specific IgE, becausethe sensitivity and specificity of specific IgE examination depend on the examination method. To know the diagnostic value of specificIgE immunoblot examination by determination and were compared with ELISA in patients with allergic rhinitis. The cross-sectionaldesign of the study is con-ducted on patients at the Outpatient Clinic Department of ENT-Head and Neck from May until October 2014.Patients were grouped as diagnosis of allergic rhinitis and non-allergic non-infectious rhinitis based on clinical signs and symptoms,physical examina-tion, positive in SPT examination with or without an increase in total serum IgE and/or blood eosinophils. SpecificIgE immunoblot was conducted by using Foresight®, Acon Laboratories and the ELISA method using Allercoat™. The sensitivity andspecificity of inhalant allergen -specific IgE immunoblot Foresight® method was 73.9% and 42.9%, respectively. The sensitivity andspecificity of inhalant allergen -specific IgE ELISA method was 67.4% and 57.1%, respectively. The results of these two methods havea correlation coefficient 0.531 with p=0.000. The sensitivity and specificity of ingestan allergen specific IgE immunoblot Foresight®method was 41.3% and 85.7%, respectively. The sensitivity and specificity of ingestan allergen specific IgE ELISA method was 17.4 and78.6%, res-pectively. Results of these two methods have a correlation coefficient 0.375 with p=0.003. Based on this study of specificIgE immunoblot and ELISA methods, both have diagnostic sensitivity and specificity, which are almost the same. The sensitivity ofimmunoblot method inhalant allergens are superior to ELISA. The Immunoblot method ingestan allergen specificity is superior toELISA.

Download Full-text

Allergic Response

10.2310/im.1232 ◽

2019 ◽

Author(s):

Joud Hajjar ◽

Lawrence B Schwartz

Keyword(s):

Mast Cell ◽

Immunoglobulin E ◽

Signs And Symptoms ◽

Specific Ige ◽

Consensus Conference ◽

Allergic Response ◽

Working Definition ◽

Keywords Allergy ◽

Ige Mediated ◽

Definition Of

Download Full-text

THE HIGH-AFFINITY IMMUNOGLOBULIN E (IgE) RECEPTOR (FcεRI) MEDIATES IgE-DEPENDENT ALLERGEN PRESENTATION

PEDIATRICS ◽

10.1542/peds.98.2.325a ◽

1996 ◽

Vol 98 (2) ◽

pp. 325-325

Author(s):

Russell Hopp

Keyword(s):

Immunoglobulin E ◽

Late Phase ◽

Specific Ige ◽

Delayed Response ◽

Target Area ◽

Type I ◽

Ige Receptor ◽

High Affinity ◽

Ige Receptors ◽

Response Target

Low numbers of monocytes with highaffinity IgE receptors and bound-specific IgE, attracted to the late-phase response target area (skin, nose, or lungs) may be a prime cell for the initiation of further Type I immediate and Type I late-phase responses (referred to as T cell mediated, delayed response, in this paper).

Download Full-text

Comparison between Specific Immunoglobulin E and Skin Prick Test for Diagnosis of Allergic Patients

10.51429/ejmm29422 ◽

2020 ◽

Vol EJMM29 (4) ◽

pp. 173-179

Author(s):

Wafaa S. Metwally ◽

Ghada A. Mokhtar

Keyword(s):

Skin Prick Test ◽

Immunoglobulin E ◽

Diagnostic Yield ◽

Good Alternative ◽

Specific Ige ◽

Gold Standard Method ◽

Serum Ige ◽

Prick Test ◽

Serum Total Ige

Background: Skin prick test (SPT) has been identified as the gold standard method to diagnose IgE mediated hypersensitivities; it is accurate, easy and cheap. However, SPT has some important limitations, so in vitro serum specific serum IgE (sSIgE) detection can be a good alternative. The diagnostic yield of sSIgE testing usually depends on the specific allergen. Objective: This study compares between SPT and sSIgE for diagnosis of allergy. Methodology: 61 allergic patients enrolled from Zagazig University Allergy and Immunology Unit, tested by SPT for the common allergens. Serum total IgE and specific IgE levels were measured and compared to SPT results. Results: The over- all sensitivities of sSIgE were excellent (75-100%) for most of allergens tested. PPV was excellent with some allergens (pollens, cockroaches, mites) and poor with others (cat hair). Sensitivity of mites sSIgE was excellent with PPV approaching 90%, specificiy was only 13%. However, the NPV was 100%. Significant level of agreement and correlation between the results of SPT and sSIgE for cockroaches and molds was reported. Positive correlation between the total levels of serum IgE and the diameter of wheal and flare of the SPT for mites, pollens and cockroaches was found. Conclusion: The sensitivities of sSIgE were excellent for most of allergens tested. Specificity of sSIgE varies between individual allergens. Serum specific IgE testing may be a good alternative to skin prick test if the latter could not be carried out.

Download Full-text

Allergy tests

Oxford Handbook of Clinical Immunology and Allergy ◽

10.1093/med/9780199603244.003.0019 ◽

2013 ◽

pp. 533-554

Author(s):

Gavin P Spickett

Keyword(s):

Drug Allergy ◽

Immunoglobulin E ◽

Eosinophil Cationic Protein ◽

Basophil Activation Test ◽

Specific Ige ◽

Ige Receptor ◽

Cationic Protein ◽

Challenge Tests ◽

Specific Igg ◽

Receptor Antibodies

Introduction Allergen-specific IgE Allergen-specific IgG antibodies Basophil activation test CD23, soluble (Fcε‎ receptor) C3a, C4a, and C5a (anaphylotoxins) Challenge tests Drug allergy testing Eosinophil cationic protein (ECP) Eosinophil count Flow-CAST® and CAST-ELISA® Histamine-release assays Immunoglobulin E (total IgE) IgE autoantibodies/IgE receptor antibodies...

Download Full-text

The Effect of Birch Pollen Immunotherapy on Apple and rMal d 1 Challenges in Adults with Apple Allergy

Nutrients ◽

10.3390/nu12020519 ◽

2020 ◽

Vol 12 (2) ◽

pp. 519 ◽

Cited By ~ 3

Author(s):

Johanna van der Valk ◽

Birgit Nagl ◽

Roy Gerth van Wljk ◽

Barbara Bohle ◽

Nicolette de Jong

Keyword(s):

Skin Prick Test ◽

Challenge Test ◽

Birch Pollen ◽

Food Challenge ◽

Specific Ige ◽

P Value ◽

Double Blind ◽

P Values ◽

Prick Test ◽

Bet V 1

Background: A proportion of patients allergic to birch pollen are also allergic to pit fruit. The objective of this study was to investigate the effect of immunotherapy with birch pollen on birch-pollen-related apple allergy. Method: Patients with birch pollen immunotherapy underwent a skin-prick test with birch pollen, apple and rMal d 1, global assessments and nasal challenges with birch pollen, open food challenge with apple and a double-blind, placebo-controlled test with rMal d 1 at the start of and during the immunotherapy. Measurements of specific IgE in response to Bet v 1 and rMal d 1 and IgG4 in response to Bet v 1 and rMal d 1 took place. Results: Six of eight patients demonstrated an improvement of nasal challenge test results and all patients improved on global assessment during the immunotherapy. The median oral dose of apple required to elicit a reaction increased but was not statistically significant. The patients showed a decrease in skin-prick test values in response to birch pollen (1.05 to 0.36), apple (0.78 to 0.25) and rMal d 1 (0.51 to 0.10) with p-values of 0.04, 0.03 and 0.06, respectively and a decrease of specific IgE in response to Bet v 1 (10.66 kU/L to 5.19 kU/L) and rMal d 1 (0.99 to 0.61 kU/L) with p-values of 0.01 and 0.05, respectively. Only the median specific IgG4 value to Bet v 1 increased from 0.05 to 1.85 mg/L (p-value of 0.02) and not to IgG4 rMal d 1 (0.07 to 0.08 kU/L). Conclusion: The beneficial effects of immunotherapy for birch pollen were accompanied by a limited effect on apple allergy.

Download Full-text