scholarly journals Unique Presentation of Squamous Cell Carcinoma as Giant Cutaneous Horn

2019 ◽  
Vol 103 (9-10) ◽  
pp. 505-508
Author(s):  
Mohammad Fazelul Rahman Shoeb ◽  
Sanna Adappa
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Local Excision ◽  
Squamous Cell ◽  
Wide Local Excision ◽  
Verrucous Carcinoma ◽  
Histopathologic Examination ◽  
Unique Case ◽  
Cutaneous Horn

Cutaneous horn is a conical, dense, and hyperkeratotic protrusion that often appears similar to the horn of an animal. Giant cutaneous horns are rare; no incidence or prevalence has been reported. The significance of cutaneous horns is that they occur in association with, or as a response to, a wide variety of underlying benign, premalignant, and malignant cutaneous diseases. Herein we report a unique case of a 60-year-old male with a giant cutaneous horn (size: 10 cm × 2 cm) projecting from the left angle of mouth, which is extremely rare. Wide local excision of the growth was done. Histopathologic examination showed verrucous carcinoma with negative margin. There is no recurrence after follow-up of 2 years.

Cutaneous Angiosarcoma of the Scalp Masquerading as a Squamous Cell Carcinoma: Case Report and Literature Review

2012 ◽  
Vol 16 (3) ◽  
pp. 187-190 ◽  
Author(s):  
Padmanabhan Dhanasekar ◽  
Vilvapathy Senguttuvan Karthikeyan ◽  
Nagarajan Rajkumar ◽  
Sarath Chandra Sistla ◽  
S. Manwar Ali ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Case Report ◽  
Cell Carcinoma ◽  
Local Excision ◽  
Squamous Cell ◽  
Wide Local Excision ◽  
Kaposi Sarcoma ◽  
Neck Region ◽  
The Elderly ◽  
Elderly Male

Background: Cutaneous angiosarcoma is a rare tumor of the elderly male, most commonly affecting the head and neck region. It is difficult to differentiate this tumor from hemangiomas, hemangioblastomas, Kaposi sarcoma, squamous cell carcinoma and anaplastic melanomas. Methods: Case report and review of pertinent English medical literature. Case summary: We report a case of a 60-year-old male presenting with multiple nodules over the scalp where a preoperative histopathologic diagnosis of squamous cell carcinoma was made by wedge biopsy from the tumor. Postoperative histopathology and immuno histochemistry of the wide local excision specimen proved the tumor to be cutaneous angiosarcoma and the patient completed adjuvant radiotherapy. He is now on regular follow-up for 1 year without recurrence. Conclusions: Cutaneous angiosarcoma must be kept in mind in view of its rarity especially in extensive involvement of the scalp by malignancy. The primary treatment is wide local excision with adequate skin cover and adjuvant chemotherapy and radiotherapy in positive margins and lymph node metastasis.

scholarly journals The management of non-melanocytic skin malignancies of the scalp and calvarium

2014 ◽  
Vol 47 (01) ◽  
pp. 36-42 ◽  
Author(s):  
Harun Çöloğlu ◽  
Burak Özkan ◽  
Mesut Şener ◽  
Ahmet Çağri Uysal ◽  
Hüseyin Borman
Keyword(s):  
Squamous Cell Carcinoma ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Local Excision ◽  
Squamous Cell ◽  
Wide Local Excision ◽  
Locally Advanced ◽  
Histopathological Diagnosis ◽  
Full Thickness ◽  
Adjacent Structures

ABSTRACT Background: The management of advanced cutaneous malignancies has been controversial. Thirteen patients with nonmelanoma skin neoplasias that had invaded the bone of the calvarium and scalp were treated in our centre. Objective: The purpose of this study was to evaluate our experience in treating these malignancies with scalp resection and full or partial thickness cranium reconstruction. Patients and Methods: From June 2008 to March 2012, thirteen patients with locally advanced tumours of the scalp invading the calvarium were treated with wide local excision of the scalp combined with an underlying craniectomy and dural resection if needed. Results: Using histopathological diagnosis eleven patients were diagnosed with basal cell carcinoma and two patients with squamous cell carcinoma. A full thickness cranium resection was performed in seven patients and partial in six patients. Conclusion: These large cancers occasionally invade adjacent structures, as well as bone, presenting a challenging surgical problem. In general, giant rotational or island scalp flaps and free tissue transfers are needed to close the area. Finding clean margins are an important part of treating patients with bone involvement and can usually be attained using outer tabula curettage thus preventing unnecessary morbidity.

A RARE CASE OF PRIMARY SQUAMOUS CELL CARCINOMA AT ILEOSTOMY SITE: CASE REPORT

2021 ◽  
pp. 58-59
Author(s):  
Hitesh Soni ◽  
Saurabh Kalia ◽  
J M Mehta ◽  
Manisha Agarwal
Keyword(s):  
Squamous Cell Carcinoma ◽  
Case Report ◽  
Cell Carcinoma ◽  
Local Excision ◽  
Squamous Cell ◽  
Wide Local Excision ◽  
En Bloc Resection ◽  
Bloc Resection ◽  
Primary Squamous Cell Carcinoma ◽  
En Bloc

Primary squamous cell carcinoma at ileostomy site is extremely rare and there are only eight reported cases prior to our report. The present case report describes a patient of ileostomy formation 12 years prior to evaluation after total colectomy who now presented with mass at stomal and parastomal site and underwent biopsy and Positron emission tomography (PET) scan. Tumor was suspected and hence wide local excision with en bloc resection of the ileostomy and ileo-rectal anastomosis was done and histopathology showed differentiated Squamous cell carcinoma (SCC), Grade 1. This case underlines the need of regular follow-up of patients with stomas to allow the timely detection of stomal problems and the early diagnosis and management of the rare complication of parastomal squamous-cell carcinoma. Also, persistent peristomal ulcerations and proliferative lesions must undergo biopsies to rule out malignancy. Wide local excision of the carcinoma with en bloc resection of ileostomy and formation of new ileostomy at a different site is usually done to manage such cases.

SQUAMOUS CELL CARCINOMA OF THE TEMPORAL REGION MANAGED WITH WIDE LOCAL EXCISION AND FREE LATERAL THIGH FLAP COVER

2021 ◽  
pp. 72-73
Author(s):  
Surya Rao Rao Venkata Mahipathy ◽  
Narayanamurthy Sundaramurthy ◽  
Alagar Raja Durairaj ◽  
Anand Prasath Jayachandiran ◽  
Suresh Rajendran
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Local Excision ◽  
Squamous Cell ◽  
Wide Local Excision ◽  
Chemical Exposure ◽  
Temporal Region ◽  
The Face ◽  
Lateral Thigh ◽  
Flap Cover

Squamous cell carcinoma is the second most common form of cutaneous malignancy and is usually due to exposure of ultraviolet radiation (UV-B), inammation (from trauma or burns), chemical exposure and immunosuppression. Squamous cell carcinoma is a malignant proliferation of the epidermal keratinocyte. It is most common in elderly Caucasian population. Lesions occur most commonly on the face, neck, ears, hands and arms but metastases are rare. Here, we present a case of an elderly gentleman who came with an ulceroproliferative lesion of the left temporal scalp for 6 months. Biopsy proved to be a well differentiated squamous cell carcinoma. Wide local excision was done and the defect was closed using a free thin lateral thigh ap.

scholarly journals Squamous Cell Carcinoma of Nose: An Unusual Presentation

2011 ◽  
Vol 4 (3) ◽  
pp. 166-167
Author(s):  
Aseem Mishra ◽  
Smita K Nagle ◽  
Vikram Oberoi ◽  
Mohan Vasant Jagade ◽  
Vimal Kasbekar
Keyword(s):  
Squamous Cell Carcinoma ◽  
Basal Cell Carcinoma ◽  
Human Papilloma Virus ◽  
Cell Carcinoma ◽  
Local Excision ◽  
Squamous Cell ◽  
Wide Local Excision ◽  
Histopathological Diagnosis ◽  
Papilloma Virus ◽  
Nasal Vestibule

ABSTRACT Most commonly, a carcinoma of nose is a basal cell carcinoma and a squamous cell carcinoma commonly arise from the dorsum of the nose. We present here a case of 35-year-old female with a squamous cell carcinoma of the nasal vestibule, which started as a wart and was very slowly progressive, until it was excised by a practitioner in a village. It then progressed rapidly and presented to us. The mass appeared a squamous cell carcinoma arising from nasal vestibule. The wart-like presentation also associates the etiology of squamous cell carcinoma to human papilloma virus and the disadvantages of excision of mass without proper histopathological diagnosis. The case was successfully managed with wide local excision with reconstruction by buccal and Estlander's flap.

scholarly journals Recurrent verrucous carcinoma of the foot: A case report

2016 ◽  
Vol 1 (1) ◽  
Author(s):  
Jayabal Pandiaraja ◽  
Selvaraju Uthayam
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Verrucous Carcinoma ◽  
Surgical Margin ◽  
Metastatic Potential ◽  
History Of ◽  
Forefoot Amputation ◽  
Slow Growing

<p>Verrucous carcinoma is an uncommon, locally invasive and slow growing squamous cell carcinoma of the skin and mucous membrane. The proposed causative agent for verrucous carcinoma is human papillomavirus (HPV). It has low metastatic potential compared to squamous cell carcinoma. This is a report of a 75-year-old male admitted with history of growth over the forefoot. Histopathological examinations confirmed verrucous carcinoma and the patient underwent forefoot amputation with 2 cm clear surgical margin. During the 4th month of follow-up, the patient developed a lesion at the post-operative site which was proven as a recurrence. Even though it carried low metastatic potential, it needed repeated resection or amputation because of high local recurrence.</p><p> </p>

scholarly journals Post-operative radiation therapy with or without chemotherapy for anal squamous cell carcinoma incidentally discovered after local excision: a propensity score matched analysis of retrospective multicenter study

2020 ◽  
Vol 93 (1106) ◽  
pp. 20190667 ◽  
Author(s):  
Kyung Su Kim ◽  
Ah Ram Chang ◽  
Kyubo Kim ◽  
Hyeon Kang Koh ◽  
Won Il Jang ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Radiation Therapy ◽  
Propensity Score ◽  
Cell Carcinoma ◽  
Treatment Outcomes ◽  
Local Excision ◽  
Squamous Cell ◽  
Concurrent Chemotherapy ◽  
Anal Squamous Cell Carcinoma

Objective: To evaluate the results of post-operative radiation therapy (RT) for anal squamous cell carcinoma (ASCC) incidentally detected after excision, and compare these outcomes with those of definitive RT without excision for exploring the possibility of treatment de-intensification Methods and materials: A total of 25 patients with T1–2N0-1 ASCC who underwent RT following incidental tumor resection were selected from multicenter retrospective database. And, we selected one-to-one matched 25 patients receiving definitive RT from the same database using propensity score matching method, and the outcomes were compared. Results: Median age was 60 years (range, 30–76), and 18 patients (72%) were female. 19 patients (76%) had T0/1 tumors and four patients (16%) had regional lymph node metastases. Hemorrhoidectomy was performed in eight patients (32%) and the others underwent local excision. 12 patients (48%) had microscopic or gross residual diseases. Median RT dose to the primary lesion was 50.4 Gy (range, 40–60). Concurrent chemotherapy was delivered to 23 patients (92%). Median follow-up period was 71 months (range, 4.5–203.1 months). None of the patients showed recurrence during follow-up. However, one patient died after 6 months due to the chemotherapy-related hematologic toxicity. When compared with those patients receiving definitive RT, clinicopathological variables were well-balanced between the two groups. While matched paired patients treated with definitive RT received a higher median RT dose of 54 Gy (range, 45–61.2) and concurrent chemotherapy was given to 22 patients (88%), overall survival was not significantly different (p = 0.262). Conclusion: Patients treated with RT for early stage ASCC after local excision showed favorable treatment outcomes. Further study is warranted to justify the de-intensification of the treatment for these patients. Advances in knowledge: Post-operative RT can achieve favorable treatment outcomes in incidental ASCC with residual diseases after local excision.

scholarly journals Predictability of Recurrence using Immunohistochemistry to delineate Surgical Margins in mucosal Head and Neck Squamous Cell Carcinoma (PRISM-HNSCC): study protocol for a prospective, observational and bilateral study in Australia and India

BMJ Open ◽  
2017 ◽  
Vol 7 (10) ◽  
pp. e014824 ◽  
Author(s):  
Sheela Joseph ◽  
Rajinikanth Janakiraman ◽  
Geeta Chacko ◽  
Rama Jayaraj ◽  
Mahiban Thomas ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Local Excision ◽  
Squamous Cell ◽  
Study Protocol ◽  
Wide Local Excision ◽  
Disease Recurrence ◽  
Surgical Margins ◽  
Lugol’S Iodine

ObjectivesTreatment failure and poor 5-year survival in mucosal head and neck squamous cell carcinoma (HNSCC) has remained unchanged for decades mainly due to advanced stage of presentation and high rates of recurrence. Incomplete surgical removal of the tumour, attributed to lack of reliable methods to delineate the surgical margins, is a major cause of disease recurrence. The predictability of recurrence using immunohistochemistry (IHC) to delineate surgical margins (PRISM) in mucosal HNSCC study aims to redefine margin status by identifying the true extent of the tumour at the molecular level by performing IHC with molecular markers, eukaryotic initiation factor, eIF4Eand tumour suppressor gene, p53, on the surgical margins and test the use of Lugol’s iodine and fluorescence visualisation prior to the wide local excision. This article describes the study protocol at its pre - results stage.Methods and analysisPRISM-HNSCC is a bilateral observational research being conducted in Darwin, Australia and Vellore, India. Individuals diagnosed with HNSCC will undergo the routine wide local excision of the tumour followed by histopathological assessment. Tumours with clear surgical margins that satisfy the exclusion criteria will be selected for further staining of the margins with eIF4E and p53 antibodies. Results of IHC staining will be correlated with recurrences in an attempt to predict the risk of disease recurrence. Patients in Darwin will undergo intraoperative staining of the lesion with Lugol’s iodine and fluorescence visualisation to delineate the excision margins while patients in Vellore will not undertake these tests. The outcomes will be analysed.Ethics and disseminationThe PRISM-HNSCC study was approved by the institutional ethics committees in Darwin (Human Research Ethics Committee 13-2036) and Vellore (Institutional Review Board Min. no. 8967). Outcomes will be disseminated through publications in academic journals and presentations at educational meetings and conferences. It will be presented as dissertation at the Charles Darwin University. We will communicate the study results to both participating sites. Participating sites will communicate results with patients who have indicated an interest in knowing the results.Trial registration numberAustralian New Zealand Clinical Trials Registry (ACTRN12616000715471).

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