scholarly journals Comparative Analysis of Visual Inspection with Acetic Acid And Lugol’s Iodine And Liquiprep TM in Cervical Cancer Screening with Cervical Biopsy As Gold Standard

2016 ◽  
Vol 15 (07) ◽  
pp. 54-62 ◽  
Author(s):  
Dr.S.Anitha Rani ◽  
Dr.K. Rama
2003 ◽  
Vol 106 (3) ◽  
pp. 404-408 ◽  
Author(s):  
Rengaswamy Sankaranarayanan ◽  
Ramani Wesley ◽  
Somanathan Thara ◽  
Namrata Dhakad ◽  
Bharathykutty Chandralekha ◽  
...  

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. e12009-e12009
Author(s):  
Surbhi Grover ◽  
Melody Ju ◽  
Lilie L. Lin ◽  
Shobha Krishnan

e12009 Background: Visual inspection with acetic acid and Lugol’s iodine (VIA/VILI) is increasingly reframed as a bridge modality through which low resource countries can provide cervical cancer screening while waiting for the more effective HPV DNA tests to become affordable. Often the screening programs are organized by government bodies that lack the trust of the local communities and hence such programs suffer from poor participation. Here we aim to describe a locally-sustained VIA/VILI screening program in rural Kutch district in India directed by Kutch Mahlia Vikas Sangathan (KMVS), a local NGO committed to women empowerment. Methods: All capacity-building measures (funding, training, materials, and healthcare workers) were rooted in the local community. Heath workers were sent to Tata Memorial Cancer Center in Mumbai for training. NGO members held information sessions prior the screening camps educating women about the significance of screening. A three-visit screening model using VIA/VILI was implemented. At first visit, all women were consented and screened. VIA/VILI positive women returned for a second visit for biospy. Biopsy positive women then returned for a third visit to arrange for treatment. All the screening camps were conducted in community buildings such as schools with the collaboration of the village leaders. Results: Screening camps were set up in 17 villages in 2010-2011, screening a total of 832 married women upto the age of 50. There were 0 cervical intraepithelial neoplasia (CIN) positive lesions or invasive cancers found. None of the women were lost to follow-up. Conclusions: It is feasible to develop a community level screening program and to provide cancer prevention needs from within a community. Future directions include further evaluation of downstream protocols after VIA/VILI tests, increasing health worker diagnostic and treatment capacity, and determining positive recruitment factors in women attending screening camps. The KMVS screening program has been well-received and has been approached by several other NGO’s and training centers seeking to build similar community-based cervical cancer screening programs.


2020 ◽  
Vol 18 (3) ◽  
pp. 426-430
Author(s):  
Bigya Shrestha ◽  
Karishma Malla Vaidya ◽  
Rijuta Joshi

Background: Cervical cancer is the second most common cancer among women in developing countries. Cervical cancer generally develops slowly over a period of 10-15 years. Incidence and mortality related to cervical cancer both have declining in developed countries because of effective screening programs through Papanicolaou smear. Therefore, cervical cancer can be prevented through implementation of different methods of screening programs like visual inspection of cervix with application of acetic acid visual inspection with acetic acid, liquid based cytology and human papilloma virus deoxyribonucleic acid. The purpose of this study is to compare the efficacy of  visual inspection with Acetic Acid with liquid based cytology in cervical cancer screening taking cervical biopsy as a gold standard. Methods: The study was conducted at Paropakar Maternity and Women’s Hospital, Kathmandu. One hundred forty four patients underwent visual inspection with acetic acid and liquid based cytology test followed by biopsy for confirmation of the lesion, when required. Data were obtained and statistically analyzed. Results: Out of 144 screened patients, 62 (43.05%) were positive in visual inspection with acetic acid test. Eighteen (12.5%) cases were positive in liquid based cytology. Thirteen women were positive with both tests. Thirty-nine cases underwent histopathological examination including 13 cases who were positive in both tests. The sensitivity, specificity, positive predictive value and negative predictive value for visual inspection with acetic acid was 81.25%, 65.22%, 61.90% and 83.33%, whereas for liquid based cytology it was 100%, 91.30%, 88.89% and 94.87% respectively. Conclusions: Liquid based cytology was more efficacious to diagnose atypical cells with higher sensitivity and specificity in comparison to that of  visual Inspection with Acetic Acid test. Keywords: Cervical cancer; liquid based cytology; visual inspection with acetic acid


1970 ◽  
Vol 2 (2) ◽  
pp. 48-53
Author(s):  
Samira Khan ◽  
Rajshree Jha ◽  
Pradam R Pant

Aims: To study the accuracy of visual inspection using acetic acid (VIA) or Lugol's iodine (VILI) and Pap smear for cervical cancer screening comparing with the histology from positively screened women in all three. Method: In this descriptive study, 300 women 25 - 65 years from Gynecology clinic of T.U Teaching Hospital from December 2004 - 2005 underwent cervical screening. Positive tests for cytology was CIN I or above, VIA was opaque aceto white lesion on applying 4% acetic acid or detection of definite yellow iodine non uptake areas with Lugol's iodine in the transformation zone or close to touching the squamocolumnar junction. Positive cases were scheduled for colposcopy directed biopsies and histological evaluation. Results: Positive results obtained from cytology were 7.3% (22). VIA was positive in 52 women [low threshold +ve in 13.6% (41); high threshold +ve in 3.6%. (11)] VILI tested +ve in 8.7% (26). Cervical biopsy was done in 62 women who had positive result [10 were positive with all three tests, 4 were positive with VIA and Pap smear, 14 were positive with VIA and VILI. 24 were positive with only VIA, 2 were with only VILI and 8 were positive with only Pap smear]. Histology in 19 was suggestive of CIN and carcinoma. [LSIL (12), HSIL (6), carcinoma (1)] Pick up by Pap smear, VIA and VILI were 10; 17 and 15 missing respectively 9:[ LSIL (7) HSIL (2)]; [LSIL (2)] and 4 [LSIL (3) and HSIL (1)]. VIA had highest number of false positive as compared to Pap smear and VILI. Sensitivity for Pap smear (52.6%); low (81.1%)/high threshold VIA (80.0%) and VILI was (78.9%). Specificity for Pap smear (72 %); low was (20%) but high threshold VIA was similar to VILI (74.4%) The positive predictive value of low or high threshold VIA, VILI and cytology were 22.0%, 72.7%, 57.7% and 45.5%; such that the compounding NPV were 80.0%, 80.0%, 88.9% 77.5%. Overall accuracy of high threshold VIA (76 %) was comparable to VILI 75.8%; cytology having 66% and low threshold VIA with 33 %. Conclusion: High threshold VIA and VILI have higher accuracy for detection of precancerous lesions of cervix than Pap smear indicating that these test to be implicated for cancer screening which is more cost effective. Keywords: Visual inspection; acetic acid; Lugol's iodine; VIA; VILI; screening of cervical cancer; Papanicolau (Pap) smear. doi:10.3126/njog.v2i2.1455 N. J. Obstet. Gynaecol 2007 Nov-Dec; 2 (2): 48 - 53


PLoS ONE ◽  
2017 ◽  
Vol 12 (1) ◽  
pp. e0170631 ◽  
Author(s):  
Amidu O. Raifu ◽  
Mariam El-Zein ◽  
Ghislain Sangwa-Lugoma ◽  
Agnihotram Ramanakumar ◽  
Stephen D. Walter ◽  
...  

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