Detailed Chemistry Studies of 225Actinium Labeled Radiopharmaceuticals

Background: Synthesis of 225Actinium derivatives using PSMA-617, DOTATATE peptides and EDTMP ligand was afforded. Detailed experimental, quality control (QC) and stability studies were well described. The radiolabelling reactions were performed in mild conditions with desirable radiochemical yields and high radiochemical purities. Methods: PSMA-617, and DOTATATE were radiolabelled with 225Actinium in 0.1 M HCl in the presence of ascorbate buffer solution and passed through the C-18 light cartridge for purification and the product was eluted by ethanol-water solution. EDTMP was also radiolabelled with 225Actinium without using any stabilizer and purification step. All products were well analyzed by R-TLC and R-HPLC. The stability of those compounds was also studied within the valid time. Results: 225Ac-DOTATATE and 225Ac-PSMA-617 were obtained at the same condition. The radiochemical yield of 225Ac-DOTATATE was less than 225Ac-PSMA 617. Stability experiments indicated decay daughters of 225Actinium appeared after T0 +1 h due to the recoil effect radiolysis. On the other hand, 225Ac-EDTMP was more stable than DOTA-peptide radiolabelled compounds. 225Ac-EDTMP was produced with more than 95% radiochemical yield and 99% radiochemical purity. Conclusion: A detailed chemistry study was presented for the synthesis of 225Actinium derivatives in mild conditions with absolute radiochemical purities and high yields. Experimental results showed that 225Ac-EDTMP could be a suitable alternative radiopharmaceutical for bone metastases arising from primer tumors as a cocktail therapy.

Radon Progeny Recoil Effect in Retrospective Indoor Glass Dosimetry

Radon gas diffusion and progeny transport in air, are mechanisms to be considered in retrospective glass dosimetry. With the aim to contribute to the understanding of the Rn progeny recoil energy role in this dosimetry methodology, we carried out a simulation employing GEANT4 code. In that, we assumed the chemical compound of the glass that is used commonly in households. Results are compared to experimentally measured 210Bi concentration to show that the recoil energy helps the progenies incrustation, mainly for the 218,214Po alpha emitters but do not influence bismuth-210 diffusion directly. A significant difference exists between our results and measured values; that is interpreted as due to atomic displacement by primary knock-on atoms. The SiO2 molecule binding energy breaks and the following ion recombination, induce a structural modification between the atom by e.g. cavities formation in such a way that reduces significantly the radon progeny diffusion speed.

Релятивистский расчёт эффекта отдачи ядра для g-фактора состояния ^2P-=SUB=-3/2-=/SUB=- многозарядных бороподобных ионов

The nuclear recoil effect on the $^2 P_{3/2}$-state $g$ factor of B-like ions is calculated to first order in the electron-to-nucleus mass ratio $m/M$ in the range $Z=18$--$92$. The calculations are performed by means of the $1/Z$ perturbation theory. Within the independent-electron approximation, the one- and two-electron recoil contributions are evaluated to all orders in the parameter $\alpha Z$ by employing a fully relativistic approach. The interelectronic-interaction correction of first order in $1/Z$ is treated within the Breit approximation. Higher orders in $1/Z$ are partially taken into account by incorporating the screening potential into the zeroth-order Hamiltonian. The most accurate to date theoretical predictions for the nuclear recoil contribution to the bound-electron $g$ factor are obtained.

Расчеты релятивистских, корреляционных, ядерных и квантово-электродинамических поправок к энергии и потенциалу ионизации основного состояния гелиеподобных ионов

In this work, nonrelativistic and relativistic variational calculations of the energies and ionization potentials of the ground state of helium-like ions for the nuclear charges in the range Z = 2 − 20 were performed.the leading corrections to the total energy were calculated including the contribution of electronic correlations, relativistic and quantum-electrodynamic (QED) corrections, and the contributions of the finite size ofnucleus (field shift) and the finite mass of the nucleus (recoil effect). Relativistic сalculations of the wave functions were performed using the Dirac-Coulomb-Breit (DCB) Hamiltonian.