DEVELOPMENT OF AN AUTOMATED DESIGN SYSTEM FOR FLEXIBLE AUTOMATED PRODUCTION

Design of flexible manufacturing systems (FMS) of modern multi-level production is usually carried out on the basis of general rationing when using large recommendations. At the same time, the specifics and features of a particular production are not always taken into account. In such a design, the most important is the experience of the designer, which is not always based on modern methods of optimizing project solutions. Therefore, the problem of creating automated design systems in the development of flexible automated productions (FAP), which use cost equipment with numerical control (CNC) is extremely urgent. The development of automated design systems is based on the ideas of a systematic approach that determine different cycles of the process: design - production preparation - production. Information about the projected object is generated in the process of project development by different groups of users: researchers, designers, designers, technologists, production organizers. A multilevel, cyclical design process requires the use of such a volume of information that cannot be processed without the use of modern mathematical methods and calculated equipment. Therefore, it is extremely important to create automated gap design systems, which are marked by greater versatility, efficiency and possibility of development, improvement and adaptation to the conditions of various enterprises. Such requirements served as the basis for the creation of an automated design system , which allows to take into account a huge amount of information in the automatic cycle during the development of the project. The scientific novelty of the work is the development of an integrated automation system for the design of processing technology and the selection of elements of FMS structures. At the same time, information unity with the system of technological training of production at the level of operation of FMS is ensured.

MODERN INFORMATION TECHNOLOGIES IN CONSTRUCTION

The ever-increasing level of competition requires the optimization of the construction process to use automated design systems, which reduces construction costs and reduces lead time. An excellent tool for this is information technology. This article presents the main information technologies used at different stages of the life cycle of building structures.

APPROACHES FOR THE DEVELOPMENT OF FOR AUTOMATED DESIGN AND SIMULATION OF ONBOARD NETWORKS

The article presents an analysis of the development prospects for the aerospace industry in relation to on-board systems and new-generation networks. It also presents the approaches for developing the SANDS software, intended for computer-aided design and simulation of on-board networks. Various approaches are described that will allow the existing software product to be refined and updated to meet new industry demands.

Toeholder: a software for automated design and in silico validation of toehold riboswitches

Synthetic biology aims to engineer biological circuits, which often involve gene expression. A particularly promising group of regulatory elements are riboswitches because of their versatility with respect to their targets, but early synthetic designs were not as attractive because of a reduced dynamic range with respect to protein regulators. Only recently, the creation of toehold switches helped overcome this obstacle by also providing an unprecedented degree of orthogonality. However, a lack of automated design and optimization tools prevents the widespread and effective use of toehold switches in high-throughput experiments. To address this, we developed Toeholder, a comprehensive open-source software for toehold design and in silico benchmarking. Toeholder takes into consideration sequence constraints as well as data derived from molecular dynamics simulations of a toehold switch. We describe the software and its in silico validation results, as well as its potential applications and impacts on the management and design of toehold switches.