Time Perception in Prodromal Alzheimer's Dementia and in Prodromal Dementia With Lewy Bodies

Background: Time perception is a subjective experience or sense of time. Previous studies have shown that Alzheimer's dementia (AD) patients have time perception deficits compared to a cognitively unimpaired control group (CU). There are only a few studies on dementia with Lewy bodies (DLB) patients' time perception in comparison with CU and AD patients. Early intervention and prescription of the right medicine may delay the deterioration of AD and DLB, moreover, knowing how prodromal AD (prAD) and prodromal DLB's (prDLB) time perception differ from each other might be helpful for future understanding of these two dementias. Therefore, the purpose of this study is to explore the difference in time perception performance between prodromal AD and prodromal DLB.Methods: We invited people diagnosed with prAD, prDLB, and CU to participate in this study. Tests of verbal estimation of time and time interval production were used to assess their time perception. We analyzed the average time estimation (ATE), absolute error score (ABS), coefficient of variance (CV), and subjective temporal unit (STU) within the three groups.Results: A total of 40 prAD, 30 prDLB, and 47 CU completed the study. In the verbal estimation test, the CV for the prAD was higher than both prDLB and CU at the 9 s interval, and the CV of prAD was higher than CU at the 27 s interval. In the time interval production test, the subjective time units of prDLB were higher than prAD at the 10 s interval, while those of both prDLB and CU were higher than prAD at the 30 s interval. The percentage of subjects with STU < 1.0 s, indicating overestimation, was higher in prAD than both prDLB and CU.Conclusion: Time perception of prAD patients showed imprecision and overestimation of time, while prDLB tended to underestimate time intervals. No significant difference was found in accuracy among the three groups. It is speculated that the clinical and pathological severity of the two prodromal dementia stages may be different, and some patients have not yet had their time perception affected.

Correction and Validation of Time-Critical Behavioral Measurements over the Internet in the Stage Twin Cohort with More Than 7000 Participants

Behavioral data are increasingly collected over the Internet. This is particularly useful when participants’ own computers can be used as they are, without any modification that relies on their technical skills. However, the temporal accuracy in these settings is generally poor, unknown, and varies substantially across different hard- and software components. This makes it dubious to administer time-critical behavioral tests such as implicit association, reaction time, or various forms of temporal judgment/perception and production. Here, we describe the online collection and subsequent data quality control and adjustment of reaction time and time interval production data from 7127 twins sourced from the Swedish Twin Registry. The purposes are to (1) validate the data that are already and will continue to be reported in forthcoming publications (due to their utility, such as the large sample size and the twin design) and to (2) provide examples of how one might engage in post-hoc analyses of such data, and (3) explore how one might control for systematic influences from specific components in the functional chain. These possible influences include the type and version of the operating system, browser, and multimedia plug-in type

Bayes, Time Perception, and Relativity: The Central Role of Hopelessness.

Time judgement and time experience are distinct elements of time perception. It is known that time experience tends to be slow, or dilated, when depressed, but there is less certainty or clarity concerning how depression affects time judgement. Here, we use a Bayesian Prediction Error Minimisation (PEM) framework called ‘distrusting the present’ as an explanatory and predictive model of both aspects of time perception. An interval production task was designed to probe and modulate the relationship between time perception and depression. Results showed that hopelessness, a symptom of severe depression, was associated with the ordering of interval lengths, reduced overall error, and dilated time experience. We propose that ‘distrusting the future’ is accompanied by ‘trusting the present’, leading to the experiences of time dilation when depressed or hopeless. Evidence was also found to support a relative difference model of how hopelessness dilates, and arousal accelerates, the rate of experienced time.

Making Sense of Timing and Attention: Modality Effect in Timing with a Break

Tones are perceived longer than visual stimuli of same durations. One interpretation of this modality effect is that auditory stimuli capture attention more easily than visual stimuli, resulting in more efficient temporal processing. During a time interval production, expecting a break signal lengthens the produced interval, an effect explained by attention sharing between timing and monitoring for the signal occurrence. In the present study, participants produced a brief time interval defined by a visual or an auditory stimulus and in most trials, there was a break in stimulus presentation. The effect of break expectancy was significantly stronger when the timing stimulus was presented in the visual than in the auditory modality, an interaction supporting attentional interpretations of the modality and expectancy effects. We conclude that auditory stimuli orient attention to time more readily than visual stimuli in a context of attention sharing, which reduces the distracting effect of break expectancy.