DNA Mutations via Chern–Simons Currents

We test the validity of a possible schematization of DNA structure and dynamics based on the Chern–Simons theory, that is a topological field theory mostly considered in the context of effective gravity theories. By means of the expectation value of the Wilson Loop, derived from this analogue gravity approach, we find the point-like curvature of genomic strings in KRAS human gene and COVID-19 sequences, correlating this curvature with the genetic mutations. The point-like curvature profile, obtained by means of the Chern–Simons currents, can be used to infer the position of the given mutations within the genetic string. Generally, mutations take place in the highest Chern–Simons current gradient locations and subsequent mutated sequences appear to have a smoother curvature than the initial ones, in agreement with a free energy minimization argument.

Topological field theories induced by twisted R-Poisson structure in any dimension

We construct a class of topological field theories with Wess-Zumino term in spacetime dimensions ≥ 2 whose target space has a geometrical structure that suitably generalizes Poisson or twisted Poisson manifolds. Assuming a field content comprising a set of scalar fields accompanied by gauge fields of degree (1, p − 1, p) we determine a generic Wess-Zumino topological field theory in p + 1 dimensions with background data consisting of a Poisson 2-vector, a (p + 1)-vector R and a (p + 2)-form H satisfying a specific geometrical condition that defines a H-twisted R-Poisson structure of order p + 1. For this class of theories we demonstrate how a target space covariant formulation can be found by means of an auxiliary connection without torsion. Furthermore, we study admissible deformations of the generic class in special spacetime dimensions and find that they exist in dimensions 2, 3 and 4. The two-dimensional deformed field theory includes the twisted Poisson sigma model, whereas in three dimensions we find a more general structure that we call bi-twisted R-Poisson. This extends the twisted R-Poisson structure of order 3 by a non-closed 3-form and gives rise to a topological field theory whose covariant formulation requires a connection with torsion and includes a twisted Poisson sigma model in three dimensions as a special case. The relation of the corresponding structures to differential graded Q-manifolds based on the degree shifted cotangent bundle T*[p]T*[1]M is discussed, as well as the obstruction to them being QP-manifolds due to the Wess-Zumino term.

DNA Mutations via Chern-Simons Current

We test the validity of a possible schematization of DNA structure and dynamics based on the Chern-Simons theory, that is a topological field theory mostly considered in the context of effective gravity theories. By means of the expectation value of the Wilson Loop, derived from this analogue gravity approach, we find the point-like curvature of genomic strings in KRAS human gene and COVID-19 sequences, correlating this curvature with the genetic mutations. The point-like curvature profile, obtained by means of the Chern-Simons currents, can be used to infer the position of the given mutations within the genetic string. Generally, mutations take place in the highest Chern-Simons current gradient locations and subsequent mutated sequences appear to have a smoother curvature than the initial ones, in agreement with a free energy minimization argument.

On dualizability of braided tensor categories

We study the question of dualizability in higher Morita categories of locally presentable tensor categories and braided tensor categories. Our main results are that the 3-category of rigid tensor categories with enough compact projectives is 2-dualizable, that the 4-category of rigid braided tensor categories with enough compact projectives is 3-dualizable, and that (in characteristic zero) the 4-category of braided multi-fusion categories is 4-dualizable. Via the cobordism hypothesis, this produces respectively two-, three- and four-dimensional framed local topological field theories. In particular, we produce a framed three-dimensional local topological field theory attached to the category of representations of a quantum group at any value of $q$ .

Quarter-BPS states, multi-symmetric functions and set partitions

We give a construction of general holomorphic quarter BPS operators in $$ \mathcal{N} $$ N = 4 SYM at weak coupling with U(N) gauge group at finite N. The construction employs the Möbius inversion formula for set partitions, applied to multi-symmetric functions, alongside computations in the group algebras of symmetric groups. We present a computational algorithm which produces an orthogonal basis for the physical inner product on the space of holomorphic operators. The basis is labelled by a U(2) Young diagram, a U(N) Young diagram and an additional plethystic multiplicity label. We describe precision counting results of quarter BPS states which are expected to be reproducible from dual computations with giant gravitons in the bulk, including a symmetry relating sphere and AdS giants within the quarter BPS sector. In the case n ≤ N (n being the dimension of the composite operator) the construction is analytic, using multi-symmetric functions and U(2) Clebsch-Gordan coefficients. Counting and correlators of the BPS operators can be encoded in a two-dimensional topological field theory based on permutation algebras and equipped with appropriate defects.

Flat Structure on the Space of Isomonodromic Deformations

Flat structure was introduced by K. Saito and his collaborators at the end of 1970's. Independently the WDVV equation arose from the 2D topological field theory. B. Dubrovin unified these two notions as Frobenius manifold structure. In this paper, we study isomonodromic deformations of an Okubo system, which is a special kind of systems of linear differential equations. We show that the space of independent variables of such isomonodromic deformations can be equipped with a Saito structure (without a metric), which was introduced by C. Sabbah as a generalization of Frobenius manifold. As its consequence, we introduce flat basic invariants of well-generated finite complex reflection groups and give explicit descriptions of Saito structures (without metrics) obtained from algebraic solutions to the sixth Painlevé equation.