growth morphology
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2022 ◽  
Vol 79 (2) ◽  
Author(s):  
Soukaina Ziyadi ◽  
Abdelghani Iddar ◽  
Mostafa Kabine ◽  
Mohammed El Mzibri ◽  
Adnane Moutaouakkil

2021 ◽  
Vol 204 (1) ◽  
Author(s):  
Mahsa Zarei ◽  
Mohammad Mir-Derikvand ◽  
Hamzeh Hosseinpour ◽  
Touran Rabiee Samani ◽  
Razieh Ghasemi ◽  
...  

2021 ◽  
pp. 163172
Author(s):  
M.S. Chang ◽  
M.A.A. Mohd Salleh ◽  
D.S.C. Halin ◽  
M.I.I. Ramli ◽  
H. Yasuda ◽  
...  
Keyword(s):  

2021 ◽  
pp. 134004
Author(s):  
Yan Xie ◽  
Tao Zheng ◽  
Yu-Jie Zhu ◽  
Jin-Rong Zhong ◽  
Jing-Chun Feng ◽  
...  

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Darian J. Santana ◽  
Teresa R. O’Meara

AbstractCandida auris is an emerging healthcare-associated pathogen of global concern. Recent reports have identified C. auris isolates that grow in cellular aggregates or filaments, often without a clear genetic explanation. To investigate the regulation of C. auris morphogenesis, we applied an Agrobacterium-mediated transformation system to all four C. auris clades. We identified aggregating mutants associated with disruption of chitin regulation, while disruption of ELM1 produced a polarized, filamentous growth morphology. We developed a transiently expressed Cas9 and sgRNA system for C. auris that significantly increased targeted transformation efficiency across the four C. auris clades. Using this system, we confirmed the roles of C. auris morphogenesis regulators. Morphogenic mutants showed dysregulated chitinase expression, attenuated virulence, and altered antifungal susceptibility. Our findings provide insights into the genetic regulation of aggregating and filamentous morphogenesis in C. auris. Furthermore, the genetic tools described here will allow for efficient manipulation of the C. auris genome.


Crystals ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. 1430
Author(s):  
Xuejiao Wang ◽  
Benyan Xu ◽  
Kunpeng Wang ◽  
Zhenyou Li ◽  
Jianxiu Zhang ◽  
...  

Comprehensive ab initio electronic structure calculations were performed for a newly developed deep-ultraviolet (DUV) non-linear optical (NLO) crystal Ca2B10O14F6 (CBOF) using the first principle method. Fifteen point defects including interstitial, vacancy, antisite, Frenkel, and Schottky of Ca, O, F, and B atoms in CBOF were thoroughly investigated as well as their effects on the optical absorption properties. Their formation energies and the equilibrium concentrations were also calculated by ab initio total energy calculations. The growth morphology was quantitatively analyzed using the Hartman–Perdok approach. The formation energy of interstitial F (Fi) and antisite defect OF were calculated to be approximately 0.33 eV and 0.83 eV, suggesting that they might be the dominant defects in the CBOF material. The absorption centers might be induced by the O and F vacancies (VF, VO), interstitial B and O (Oi, Bi), and the antisite defect O substitute of F (OF), which might be responsible for lowering the damage threshold of CBOF. The ionic conductivity might be increased by the Ca vacancy (Vca), and, therefore, the laser-induced damage threshold decreases.


2021 ◽  
pp. 102953
Author(s):  
Pian Xu ◽  
Gang Lu ◽  
Lei Zhang ◽  
Shitong Zhou ◽  
Yuping Yan ◽  
...  

2021 ◽  
Vol 555 ◽  
pp. 153110
Author(s):  
Kui Liu ◽  
Tan tan ◽  
Xuanpu Zhou ◽  
Nantao Zheng ◽  
Yue Ma ◽  
...  

2021 ◽  
Vol 289 ◽  
pp. 110455
Author(s):  
Jie Zou ◽  
Dimitrios Fanourakis ◽  
Georgios Tsaniklidis ◽  
Ruifeng Cheng ◽  
Qichang Yang ◽  
...  

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