Response outcome gates the effect of spontaneous cortical state fluctuations on perceptual decisions

Sensory responses of cortical neurons are more discriminable when evoked on a baseline of desynchronized spontaneous activity, but cortical desynchronization has not generally been associated with more accurate perceptual decisions. Here we show that mice perform more accurate auditory judgements when activity in the auditory cortex is elevated and desynchronized before stimulus onset, but only if the previous trial was an error, and that this relationship is occluded if previous outcome is ignored. We confirmed that the outcome-dependent effect of brain state on performance is neither due to idiosyncratic associations between the slow components of either signal, nor to the existence of specific cortical states evident only after errors. Instead, errors appear to gate the effect of cortical state fluctuations on discrimination accuracy. Neither facial movements nor pupil size during the baseline were associated with accuracy, but they were predictive of measures of responsivity, such as the probability of not responding to the stimulus or of responding prematurely. These results suggest that the functional role of cortical state on behavior is dynamic and constantly regulated by performance monitoring systems.

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Developmental loss of ErbB4 in PV interneurons disrupts state-dependent cortical circuit dynamics

10.1101/2020.12.09.418590 ◽

2020 ◽

Author(s):

Renata Batista-Brito ◽

Antara Majumdar ◽

Alejandro Nuno ◽

Martin Vinck ◽

Jessica A. Cardin

Keyword(s):

Signaling Pathway ◽

Cortical Neurons ◽

Temporal Organization ◽

Spine Density ◽

Cortical Circuits ◽

Neuregulin 1 ◽

State Dependent ◽

Sensory Responses ◽

Early Developmental

AbstractGABAergic inhibition plays an important role in the establishment and maintenance of cortical circuits during development. Neuregulin 1 (Nrg1) and its interneuron-specific receptor ErbB4 are key elements of a signaling pathway critical for the maturation and proper synaptic connectivity of interneurons. Using conditional deletions of the ERBB4 gene in mice, we tested the role of this signaling pathway at two developmental timepoints in parvalbumin-expressing (PV) interneurons, the largest subpopulation of cortical GABAergic cells. Loss of ErbB4 in PV interneurons during embryonic, but not late postnatal, development leads to alterations in the activity of excitatory and inhibitory cortical neurons, along with severe disruption of cortical temporal organization. These impairments emerge by the end of the second postnatal week, prior to the complete maturation of the PV interneurons themselves. Early loss of ErbB4 in PV interneurons also results in profound dysregulation of excitatory pyramidal neuron dendritic architecture and a redistribution of spine density at the apical dendritic tuft. In association with these deficits, excitatory cortical neurons exhibit normal tuning for sensory inputs, but a loss of state-dependent modulation of the gain of sensory responses. Together these data support a key role for early developmental Nrg1/ErbB4 signaling in PV interneurons as powerful mechanism underlying the maturation of both the inhibitory and excitatory components of cortical circuits.

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Faculty Opinions recommendation of A dual role of EphB1/ephrin-B3 reverse signaling on migrating striatal and cortical neurons originating in the preoptic area: should I stay or go away?

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.726218366.793515751 ◽

2016 ◽

Author(s):

Karina Cramer

Keyword(s):

Cortical Neurons ◽

Preoptic Area ◽

Dual Role ◽

Reverse Signaling

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Cortical and Striatal Electroencephalograms and Apomorphine Effects in the FUS Mouse Model of Amyotrophic Lateral Sclerosis

Journal of Alzheimer s Disease ◽

10.3233/jad-201472 ◽

2021 ◽

pp. 1-15

Author(s):

Vasily Vorobyov ◽

Alexander Deev ◽

Frank Sengpiel ◽

Vladimir Nebogatikov ◽

Aleksey A. Ustyugov

Keyword(s):

Amyotrophic Lateral Sclerosis ◽

Motor Neurons ◽

Cortical Neurons ◽

Primary Motor Cortex ◽

Beta Activity ◽

Systemic Injection ◽

Eeg Spectra ◽

Electroencephalogram Eeg ◽

Lateral Sclerosis

Background: Amyotrophic lateral sclerosis (ALS) is characterized by degeneration of motor neurons resulting in muscle atrophy. In contrast to the lower motor neurons, the role of upper (cortical) neurons in ALS is yet unclear. Maturation of locomotor networks is supported by dopaminergic (DA) projections from substantia nigra to the spinal cord and striatum. Objective: To examine the contribution of DA mediation in the striatum-cortex networks in ALS progression. Methods: We studied electroencephalogram (EEG) from striatal putamen (Pt) and primary motor cortex (M1) in ΔFUS(1–359)-transgenic (Tg) mice, a model of ALS. EEG from M1 and Pt were recorded in freely moving young (2-month-old) and older (5-month-old) Tg and non-transgenic (nTg) mice. EEG spectra were analyzed for 30 min before and for 60 min after systemic injection of a DA mimetic, apomorphine (APO), and saline. Results: In young Tg versus nTg mice, baseline EEG spectra in M1 were comparable, whereas in Pt, beta activity in Tg mice was enhanced. In older Tg versus nTg mice, beta dominated in EEG from both M1 and Pt, whereas theta and delta 2 activities were reduced. In younger Tg versus nTg mice, APO increased theta and decreased beta 2 predominantly in M1. In older mice, APO effects in these frequency bands were inversed and accompanied by enhanced delta 2 and attenuated alpha in Tg versus nTg mice. Conclusion: We suggest that revealed EEG modifications in ΔFUS(1–359)-transgenic mice are associated with early alterations in the striatum-cortex interrelations and DA transmission followed by adaptive intracerebral transformations.

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Subcortical circuits mediate communication between primary sensory cortical areas in mice

Nature Communications ◽

10.1038/s41467-021-24200-x ◽

2021 ◽

Vol 12 (1) ◽

Author(s):

Michael Lohse ◽

Johannes C. Dahmen ◽

Victoria M. Bajo ◽

Andrew J. King

Keyword(s):

Cortical Neurons ◽

Common Property ◽

Primary Auditory Cortex ◽

Facilitatory Effect ◽

Thalamic Nuclei ◽

Auditory Midbrain ◽

Cortical Areas ◽

Auditory Responses ◽

Evoked Activity

AbstractIntegration of information across the senses is critical for perception and is a common property of neurons in the cerebral cortex, where it is thought to arise primarily from corticocortical connections. Much less is known about the role of subcortical circuits in shaping the multisensory properties of cortical neurons. We show that stimulation of the whiskers causes widespread suppression of sound-evoked activity in mouse primary auditory cortex (A1). This suppression depends on the primary somatosensory cortex (S1), and is implemented through a descending circuit that links S1, via the auditory midbrain, with thalamic neurons that project to A1. Furthermore, a direct pathway from S1 has a facilitatory effect on auditory responses in higher-order thalamic nuclei that project to other brain areas. Crossmodal corticofugal projections to the auditory midbrain and thalamus therefore play a pivotal role in integrating multisensory signals and in enabling communication between different sensory cortical areas.

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Retraction Note: Computerized Performance Monitoring Systems: Learning and Living with its Limitations

Administration and Policy in Mental Health and Mental Health Services Research ◽

10.1007/s10488-007-0119-x ◽

2007 ◽

Vol 43 (4) ◽

pp. 628-628

Author(s):

Daniel J. Luchins

Keyword(s):

Performance Monitoring ◽

Monitoring Systems ◽

Systems Learning

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Compressor Computerized Performance Monitoring System CPMS

10.2118/204582-ms ◽

2021 ◽

Author(s):

Vadim Goryachikh ◽

Fahad Alghamdi ◽

Abdulrahman Takrouni

Keyword(s):

Natural Gas ◽

Real Time ◽

Monitoring System ◽

Performance Monitoring ◽

Compressibility Factor ◽

Background Information ◽

Monitoring Systems ◽

Turbo Expander ◽

Time Calculation ◽

Performance Deterioration

Abstract Background information Natural gas liquid (NGL) production facilities, typically, utilize turbo-expander-brake compressor (TE) to generate cold for C2+ separation from the natural gas by isentropic expansion of feed stream and use energy absorbed by expansion to compress residue gas. Experience shows that during operational phase TE can exposed to operation outside of design window that may lead to machine integrity loss and consequent impact on production. At the same time, there is a lack of performance indicators that help operator to monitor operating window of the machine and proactively identify performance deterioration. For instance, TE brake compressor side is always equipped with anti-surge protection system, including surge deviation alarms and trip. However, there is often gap in monitoring deviation from stonewall region. At the same time, in some of the designs (2×50% machines) likelihood of running brake compressor in stonewall is high during one machine trip or train start-up, turndown operating modes. Also, typical compressor performance monitoring systems does not have enough dynamic parameters that may indicate machine process process performance deterioration proactively (real-time calculation of actual polytrophic efficiency, absorbed power etc.) and help operator to take action before catastrophic failure occurs. In addition, typical compressor monitoring systems are based on assumed composition and fixed compressibility factor and do not reflect actual compositions variations that may affect machine performance monitoring. To overcome issues highlighted above, Hawiyah NGL (HNGL) team has developed computerized monitoring and advisory system to monitor the performance of turbo-expander-brake compressor, proactively, identify potentially unsafe conditions or performance deterioration and advice operators on taking necessary actions to avoid unscheduled deferment of production. Computerized performance monitoring system has been implemented in HNGL DCS (Yokogawa) and utilized by control room operators on day-to-day basis. Real-time calculation, analysis and outputs produced by performance monitoring system allow operator to understand how current operating condition are far from danger zone. Proactive deviation alarms and guide messages produce by the system in case of deviation help operators to control machine from entering unsafe region. Actual polytrophic efficiency, adsorbed power calculations provide machine condition status and allow identifying long-term performance deterioration trends.

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From observation to enactment: Can dance experience enhance multisensory temporal integration?

Seeing and Perceiving ◽

10.1163/187847612x648170 ◽

2012 ◽

Vol 25 (0) ◽

pp. 188

Author(s):

Helena Sgouramani ◽

Chris Muller ◽

Leon van Noorden ◽

Marc Leman ◽

Argiro Vatakis

Keyword(s):

Motion Capture ◽

Temporal Integration ◽

Stimulus Onset ◽

Point Of View ◽

Motion Capture System ◽

Temporal Window ◽

Synchronous Condition ◽

First Time ◽

Method Of Constant Stimuli

We report two experiments aiming to define how experience and stimulus enactment affect multisensory temporal integration for ecologically-valid stimuli. In both experiments, a number of different dance steps were used as audiovisual displays at a range of stimulus onset asynchronies using the method of constant stimuli. Participants were either professional dancers or non-dancers. In Experiment 1, using a simultaneity judgment (SJ) task, we aimed at defining — for the first time — the temporal window of integration (TWI) for dancers and non-dancers and the role of experience in SJ performance. Preliminary results showed that dancers had smaller TWI in comparison to non-dancers for all stimuli tested, with higher complexity (participant rated) dance steps requiring larger auditory leads for both participant groups. In Experiment 2, we adapted a more embodied point of view by examining how enactment of the stimulus modulates the TWIs. Participants were presented with simple audiovisual dance steps that could be synchronous or asynchronous and were asked to synchronize with the audiovisual display by actually performing the step indicated. A motion capture system recorded their performance at a millisecond level of accuracy. Based on the optimal integration hypothesis, we are currently looking at the data in terms of which modality will be dominant, considering that dance is a spatially (visual) and temporally (audio) coordinated action. Any corrective adjustments, accelerations–decelerations, hesitations will be interpreted as indicators of the perception of ambiguity in comparison to their performance at the synchronous condition, thus, for the first time, an implicit SJ response will be measured.

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Temporal Dynamics of Shape Analysis in Macaque Visual Area V2

Journal of Neurophysiology ◽

10.1152/jn.00822.2003 ◽

2004 ◽

Vol 92 (5) ◽

pp. 3030-3042 ◽

Cited By ~ 47

Author(s):

Jay Hegdé ◽

David C. Van Essen

Keyword(s):

Cortical Neurons ◽

Time Course ◽

Temporal Dynamics ◽

Visual Stimulation ◽

Signal To Noise Ratio ◽

Stimulus Onset ◽

Visual Area ◽

Response Modulation ◽

Population Response ◽

Area V2

The firing rate of visual cortical neurons typically changes substantially during a sustained visual stimulus. To assess whether, and to what extent, the information about shape conveyed by neurons in visual area V2 changes over the course of the response, we recorded the responses of V2 neurons in awake, fixating monkeys while presenting a diverse set of static shape stimuli within the classical receptive field. We analyzed the time course of various measures of responsiveness and stimulus-related response modulation at the level of individual cells and of the population. For a majority of V2 cells, the response modulation was maximal during the initial transient response (40–80 ms after stimulus onset). During the same period, the population response was relatively correlated, in that V2 cells tended to respond similarly to specific subsets of stimuli. Over the ensuing 80–100 ms, the signal-to-noise ratio of individual cells generally declined, but to a lesser degree than the evoked-response rate during the corresponding time bins, and the response profiles became decorrelated for many individual cells. Concomitantly, the population response became substantially decorrelated. Our results indicate that the information about stimulus shape evolves dynamically and relatively rapidly in V2 during static visual stimulation in ways that may contribute to form discrimination.

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