Chapter 4 of Practice Research in the Human Services: A University-Agency Partnership Model offers examples of practice research that employ cross-case comparisons in order to identify practice implications and enable senior managers to identify innovations for application to their own organizations. The key steps are described, including the dialogue and negotiation process that involves the university researcher with the practice community of agency administrators. The first study described in the chapter examined welfare reform implementation by county agencies, based on interviews with social service agency staff and consumers, as well as documents relevant to each program or practice. The second study focused on organizational knowledge-sharing processes in county agencies, while the third study explored organizational growth and resilience among nonprofit organizations. Practice research principles generated by the projects relate to generalizability limitations, data source triangulation and timeliness, and case study context.