Recovery Method for Emergency Situations with Hazardous Substances Emission into the Atmosphere

The objective of this Article is development of a hazardous area extent reducing method in the atmosphere upon emergency situation occurrence with hazardous chemical and radioactive substances emission. To achieve the specified objective it is recommended to use deposition of gaseous, liquid and solid disperse hazardous particles from the atmosphere using artificial precipitation over a zone of emergency. For artificial intensification of precipitation, use of chemical and physical principles of impact on droplets formation processes in the area of clouds is proposed. A pyrotechnic composition was developed for chemical impact, which when combustion generates finely dispersed chemical centers of condensation and modifying components for hazardous chemical substances neutralization. Conducting the ionization of precipitation formation area by a strong impulse electromagnetic irradiation was proposed as a physical impact on the artificial precipitation formation processes. The laboratory study results confirmed the technical feasibility of this method implementation. To reduce the necessary radiator power, application of a multi-position radiators system with radiation focusing to one irradiation zone was proposed. The theoretical and experimental results obtained in the article are the base for development of emergency situation negative consequences reduction practical procedures through artificial precipitation initiation.

Sinensetin-Rich Fraction Solid Dispersion Inhibits Cancer Cell Cycle

Drug development efforts to find new selective and safe drugs for cancer from natural resources are promising ones. The natural products are obtained in the multiple or single compounds. One of them is a sinensetin found in ethanol extract of Orthosiphon stamineus Benth. Sinensetin could inhibit cancer cell proliferation. However, it has a poor solubility so the absorption is low and then it impacts on the low bioavailability. The solubility problem in conventional drug could be solved by pharmaceutical manipulation. In the previous research, the manipulation was tried although there was no single compound found in the material tested. We found an optimal formula of a manipulation using solid disperse system of polyethylene glycol (PEG 6000) 15 times higher than sinensetin weight. This research was focused on observing the effect of the optimal formula of solid disperse system to inhibit cancer cell cycle. The cell lines used were T47D cells. The method used was flow cytometry. The result showed that the optimum formula has a consistent effect on the concentration of 40 and 60µg/mL. The sinensetin increase cell accumulation on S phase at the percentage of 18.80% (40µg/mL) and 22.21% (60µg/mL) compared to T47D normal cells. It reflects the S phase as the longest time experienced by the cells. Inhibition on S phase (S arrest) resulted from a DNA elongation. It causes an inhibition of DNA synthesis process. It could be concluded that the solid disperse of sinensetin was active to inhibit cancer cells proliferation on phase S. Keywords: cell cycle; sinensetin; solid disperse; poor solubility