Aim. To evaluate the psychometric properties and validity of the updated version of the Dutch multidimensional European Society of Cardiology (ESC) psychosocial screening instrument in patients with heart disease and the general population. Method. 678 participants (Mage = 48.2, SD = 16.8; 46% male) of the Dutch general population and 312 cardiac patients (Mage = 65.9, SD = 9.9; 77% male) who recently received percutaneous coronary intervention completed the ESC Psychosocial screening instrument and validated questionnaires for depression (PHQ-9), anxiety (GAD-7), Type D personality (DS14), hostility (CMHS), anger (STAS-T), trauma (SRIP), and chronic work and family stress (ERI, MMQ-6). Results. Confirmatory factor analysis (CFA) confirmed that the eight screened risk factors were best measured as separate entities, rather than as broader indications of distress. Inter-instrument agreement, assessed with the intraclass coefficient (ICC) and the screening accuracy indicators (receiving operator characteristic [ROC] curves, sensitivity, specificity, and the positive and negative predictive values [PPV;NPV]) were good for most screened risk factors. PPV was low in low prevalence risk factors like anxiety and trauma. Conclusion. Overall, the current version of the ESC Psychosocial screening instrument has an acceptable performance in both populations, with a fair to excellent level of agreement with established full questionnaires. Besides a few suggestions for further refinement, the screener may be implemented in primary care and cardiological practice.