APPLICATION OF THE PONTRYAGIN MAXIMUM PRINCIPLE TO CONTROL TUMOR ANGIOGENESIS

We present a sample application covering several cases using an extension of the Pontryagin Minimum Principle (PMP) [3]. We are interested in the management of tumor angiogenesis, that is, the therapeutic management of the proliferation of cancer cells that develop new blood vessels. Let us formulate the problem and derive the optimal control and apply the Pontryagin maximum principle to our optimal trajectory, and we derive the theorem and check it with an example. Then we will study stabilization.

Sensitivity-Based Non-Linear Model Predictive Control for Aircraft Descent Operations Subject to Time Constraints

The ability to meet a controlled time of arrival while also flying a continuous descent operation will enable environmentally friendly and fuel efficient descent operations while simultaneously maintaining airport throughput. Previous work showed that model predictive control, a guidance strategy based on a reiterated update of the optimal trajectory during the descent, provides excellent environmental impact mitigation figures while meeting operational constraints in the presence of modeling errors. Despite that, the computational delay associated with the solution of the trajectory optimization problem could lead to performance degradation and stability issues. This paper proposes two guidance strategies based on the theory of neighboring extremals that alleviate this problem. Parametric sensitivities are obtained by linearization of the necessary conditions of optimality along the active optimal trajectory plan to rapidly update it for small perturbations, effectively converting the complex and time consuming non-linear programming problem into a manageable quadratic programming problem. Promising results, derived from more than 4000 simulations, show that the performance of this method is comparable to that of instantaneously recalculating the optimal trajectory at each time sample.