Various lifestyle facts influence on microbial landscape of gut and change variety of microbiota with ulcerative colitis. New technologies of nucleotide sequencing, innovating statistics and bioinformatics grade into presentation about etiology and pathogenesis of some illness, for example ulcerative colitis. Current studies demonstrate that microbiome of gut acquaint with eukaryotic and prokaryotic viruses, which make virome of gut and be much part of microbial eco-system of intestinal tract. Number of bacteriophages and viruses escalete in the context of environmental stress so microbiome of the digestive tract disturbed. When we open specific microbiota, which associated with etiology of ulcerative colitis, we will create new treatment modality. Drive of this review is generalization of information about involvement with virome in ulcerative colitis becoming. For searching the literature were use systems PubMed and GoogleScholar with keywords: ulcerative colitis, gut virome, gut microbiome. Nowadays in the literature have limited but necessary information about this question. It requires accumulation scientifi c facts for integrated data.