A Pseudo-Random Generator Whose Output is a Normal Sequence

Pseudo-random number generators (PRNGs) are widely used in computer simulation, cryptography, and many other fields. In this paper, we describe a PRNG class, which, firstly, has been successfully tested using the most powerful modern test batteries, and secondly, is proved to consist of generators that generate normal sequences. The latter property means that, for any generated sequence [Formula: see text] and any binary word [Formula: see text], we have [Formula: see text] where [Formula: see text] is the number of occurrences of [Formula: see text] in the sequence [Formula: see text], [Formula: see text].

Chromatic Variation in Late Antique Rainbows

Depictions of rainbows in late antique and early Byzantine art follow the normal sequence of the spectral colours, only some bows exclude blue and violet. Another characteristic feature of the late antique rainbow is the inclusion of white and the non-spectral hue pink. In order to investigate chromatic characteristics, I use as case studies the comparatively few extant rainbow images of third- to sixth-century date from Thessaloniki, Constantinople, Rome and Ravenna. The rainbows, depicted in a floor mosaic, three illuminated manuscripts and three monumental wall mosaic decorations, are either part of narratives or rainbow-patterned borders used to frame other scenes. To throw light on the chromatic variations, ancient descriptions of rainbows are brought into the discussion and the representations are seen in relation to meteorological research. I propose that the late antique rainbow images follow two visual traditions, both of which can be traced back to the Hellenistic period and both of which are grounded in scientific research. One is the sunrise/sunset rainbow that ranges from red to green. I argue that the exclusion of blue/violet may be due to its being more difficult to see against the sky, the wavelength of violet being closest to the boundary beyond which coloured light tends to look black. The variant type, found especially in the church mosaics, covers the whole spectrum from red via green to violet as well as pink and white. I suggest that the non-spectral pink hues can be understood as the gradations of red that can sometimes be observed in the natural bow and that the white band provides highlight, which combined with a silver line indicates a strong luminance.

Specific and Sensitive Diagnosis of BCOR-ITD in Various Cancers by Digital PCR

BCOR is an epigenetic regulator altered by various mechanisms including BCOR-internal tandem duplication (BCOR-ITD) in a wide range of cancers. Six different BCOR-ITD in the 3’-part of the coding sequence of exon 15 have been reported ranging from 89 to 114 bp in length. BCOR-ITD is a common genetic alteration found in clear cell sarcoma of the kidney and primitive myxoid mesenchymal tumor of infancy (PMMTI) and it characterizes a new type of central nervous system tumor: “CNS tumor with BCOR-ITD”. It can also be detected in undifferentiated round cell sarcoma (URCS) and in high-grade endometrial stromal sarcoma (HGESS). Therefore, it is of utmost importance to search for this genetic alteration in these cancers with the most frequent technique being RNA-sequencing. Here, we developed a new droplet PCR assay (dPCR) to detect the six sequences characterizing BCOR-ITD. To achieve this goal, we used a single colored probe to detect both the duplicated region and the normal sequence that acts as a reference. We first generated seven synthetic DNA sequences: ITD0 (the normal sequence) and ITD1 to ITD6 (the duplicated sequences described in the literature) and then we set up the optima dPCR conditions. We validated our assay on 19 samples from a representative panel of human tumors (9 HGNET-BCOR, 5 URCS, 3 HGESS, and 2 PMMTI) in which BCOR-ITD status was known using at least one other method including RNA sequencing, RT-PCR or DNA-methylation profiling for CNS tumors. Our results showed that our technique was 100% sensitive and specific. DPCR detected BCOR-ITD in 13/19 of the cases; in the remaining 6 cases additional RNA-sequencing revealed BCOR gene fusions. To conclude, in the era of histomolecular classification of human tumors, our modified dPCR assay is of particular interest to detect BCOR-ITD since it is a robust and less expensive test that can be applied to a broad spectrum of cancers that share this alteration.

SINTAKSIS (Komponen dan Struktur)

The hierarchical order of linguistic units that one level smaller will form a larger unit, namely: discourse, sentence, clause, phrase, word, morpheme, phoneme. The hierarchy is theoretically normal. In language practice there are many factors that cause deviations in the order. If in the normal sequence the level increase or decrease in the level occurs at the next level which is one level up or one level down, then in a level jump event occurs, a unit becomes a constituent in the level, at least, two levels above it. A case of level coating occurs when a constituent becomes a constituent element in the same level construction. And the case of a decrease in the level occurs when a constituent becomes another constituent element whose level is lower than the original constituent level.Keyword: syntax, type, word, phrase, sentence, discourse

Right Bundle Branch Block: Current Considerations

: RBBB, a pattern seen on the 12-lead ECG, results when normal electrical activity in the His-Purkinje system is interrupted by some reason. The normal sequence of activation is altered in RBBB, with a resultant characteristic appearance on the ECG manifest by a widened QRS complex and changes in the directional vectors of the R and S waves. This ECG pattern is often seen in clinical practice and generally regarded as benign. The anatomy, epidemiology, causes, symptoms, ECG findings and diagnosis, differential diagnosis in ECG, treatment, complications, prognosis, with respect to RBBB is outlined here, demonstrating some typical ECGs of RBBB.