This paper examines the aggregate impacts of magnetic field, thermophoresis, Brownian motion, variable viscosity, chemical reaction and radiative heat flux on the thermal putrefaction and immanent irreversibility of a channelling nanoliquid film flowing along with a slanted heated permeable plate. Following Buongiorno approach, the two-phase nanoliquid nonlinear model is obtained and addressed numerically using shooting technique as well as the Runge-Kutta- Fehlberg integration scheme. Effects of various emerging parameters on the overall flow structure with heat and mass transfer characteristics including entropy generation rate and Bejan number are displayed using diagrams and discussed. It is found that the entropy generation rate lessened with an upsurge in a magnetic field but heightened with an elevation in the buoyancy forces.