Artemisinin Cocrystals for Bioavailability Enhancement. Part 1: Formulation Design and Role of the Polymeric Excipient

2021 ◽  
Author(s):  
Manreet Kaur ◽  
Vanessa Yardley ◽  
Ke Wang ◽  
Jinit Masania ◽  
Adolfo Botana ◽  
...  
Keyword(s):  
Bioavailability Enhancement ◽  
Formulation Design

Lipidic Nanocarrier for Oral Bioavailability Enhancement of an Anticancer Agent: Formulation Design and Evaluation

2012 ◽  
Vol 11 (1) ◽  
pp. 43-52 ◽  
Author(s):  
Akash Chaurasiya ◽  
Ajeet Kumar Singh ◽  
Satish Chandra Upadhyay ◽  
Dinesh Asati ◽  
Farhan Jalees Ahmad ◽  
...  
Keyword(s):  
Oral Bioavailability ◽  
Anticancer Agent ◽  
Bioavailability Enhancement ◽  
Formulation Design

scholarly journals Emerging era of microneedle array for pharmaceutical and biomedical applications: recent advances and toxicological perspectives

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Shailesh Dugam ◽  
Rahul Tade ◽  
Rani Dhole ◽  
Sopan Nangare
Keyword(s):  
Biomedical Applications ◽  
Microneedle Array ◽  
Bioavailability Enhancement ◽  
Main Text ◽  
The Past ◽  
Recent Advancement ◽  
Insight Into

Abstract Background Microneedles (MNs) are the utmost unique, efficient, and minimally invasive inventions in the pharmaceutical field. Over the past decades, many scientists around the globe have reported MNs cautious because of their superb future in distinct areas. Concerning the wise use of MNs herein, we deal in depth with the present applications of MNs in drug delivery. Main text The present review comprises various fabrication materials and methods used for MN synthesis. The article also noted the distinctive advantages of these MNs, which holds huge potential for pharmaceutical and biomedical applications. The role of MNs in serving as a platform to treat various ailments has been explained accompanied by unusual approaches. The review also inculcates the pharmacokinetics of MNs, which includes permeation, absorption, and bioavailability enhancement. Besides this, the in vitro/in vivo toxicity, biosafety, and marketed product of MNs have been reviewed. We have also discussed the clinical trials and patents on the pharmaceutical applications of MNs in brief. Conclusion To sum up, this article gives insight into the MNs and provides a recent advancement in MNs, which pave the pathway for future pharmaceutical and biomedical applications. Graphical abstract Pharmaceutical and biomedical applications of MNs

scholarly journals Advances in nutraceutical delivery systems: From formulation design for bioavailability enhancement to efficacy and safety evaluation

2018 ◽  
Vol 78 ◽  
pp. 270-291 ◽  
Author(s):  
Raquel F.S. Gonçalves ◽  
Joana T. Martins ◽  
Catarina M.M. Duarte ◽  
António A. Vicente ◽  
Ana C. Pinheiro
Keyword(s):  
Safety Evaluation ◽  
Delivery Systems ◽  
Efficacy And Safety ◽  
Bioavailability Enhancement ◽  
Formulation Design

Enhancing Oral Bioavailability by Paclitaxel Polymeric Micelles: Role of Transmembrane Pathways in the Oral Absorption

2020 ◽  
Vol 16 (7) ◽  
pp. 1160-1168
Author(s):  
Qiaoming Liu ◽  
Meng Cheng ◽  
Jianqin Liang ◽  
Yi Jin ◽  
Jianfang Feng ◽  
...  
Keyword(s):  
Oral Bioavailability ◽  
Transport Process ◽  
Oral Absorption ◽  
Polymeric Micelles ◽  
Bioavailability Enhancement ◽  
Perfusion Model ◽  
Intestinal Membrane ◽  
Endocytosis Pathway

The oral administration of paclitaxel suffering obstacles like poorly solubility and low permeability, causing extremely low oral bioavailability. In this study, we aim to study the role of transmembrane pathway on the absorption mechanisms of PTX-Micelles. In addition, we will further study the permeability of PTX-Micelles by employing in situ perfusion model. The results showed the PTX-Micelles could be up taken by caco-2 intact. In addition, we found that the endocytosis pathway and M cells pathway attended, while paracellular pathway absented in the transport process of PTX-Micelles. The study on in situ perfusion showed the absorption rate constant (Ka) of PTX was enhanced from 6.3, 6.1, 10.6 and 13.6 × 10–2/min to 15.1, 18.4, 45.6 and 42.9 × 10–2/min by micelles in duodenum, jejunum, ileum and colon, respectively, indicating the PTX-Micelles could enhance the permeability of PTX in intestinal membrane. This study indicating that transmembrane pathway-mediated transport is an important part in the transport process of polymeric micelles, and designing formulation based on transmembrane pathways may be a promising route for oral bioavailability enhancement of poor-soluble drugs.

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