An NHC and photo-redox co-catalyzed α-amino acid
decarboxylative carbonylation reaction was presented here. This method displayed
good scope generality, providing an easy and direct pathway to access various
downstream α-amino ketones from readily accessible starting materials under bio- and medicinally compatible conditions. Moreover, this
strategy is appealing to chemical biology since it
has great potential for chemical modification of peptides or late-stage
synthesis of keto-peptides.
An NHC and photo-redox co-catalyzed α-amino acid
decarboxylative carbonylation reaction was presented here. This method displayed
good scope generality, providing an easy and direct pathway to access various
downstream α-amino ketones from readily accessible starting materials under bio- and medicinally compatible conditions. Moreover, this
strategy is appealing to chemical biology since it
has great potential for chemical modification of peptides or late-stage
synthesis of keto-peptides.
Mechanism of CO2 reduction in carbonylation reaction promoted by ionic liquid additives: A computational and experimental study
