AB0196 SURVIVAL ANALYSIS OF TIME TO FIRST ADVERSE DRUG REACTION AND DRUG SURVIVAL IN RHEUMATOID ARTHRITIS PATIENTS TREATED WITH ADALIMUMAB AND ETANERCEPT

Background:Treatment of rheumatoid arthritis (RA) with biologic disease-modifying antirheumatic drugs (bDMARDs) has been common practice in the last two decades. However, differences in patients experiencing adverse drug reactions (ADRs) between individual bDMARDs, such as adalimumab (ADA) and etanercept (ETN), during first time treatment has not been studied yet in real-world settings.Objectives:To compare proportions of RA patients experiencing ADRs as well as survival to first ADR and drug survival during treatment with ADA and ETN.Methods:Retrospective single centre cohort study including adult patients with RA, treated with either ADA or ETN between 1 January 2003 and 30 April 2020. The proportions of patients experiencing an ADR were compared by assessing the percentage of patients, treated with either ADA or ETN, experiencing at least one ADR during their first time treatment. Survival to first ADR and drug survival were assessed by calculating time between start of treatment and first ADR and start of treatment and discontinuation of treatment respectively. Stop and restart of treatment within 90 days was considered as continuous use. Differences in proportions were statistically tested using Fisher’s Exact Test. Differences in drug survival between ADA and ETN were tested by Kaplan-Meier analysis and Log Rank tests.Results:A total of 422 patients were included in this study (ADA 259, ETN 163). For 93 patients (21.2%) an ADR was registered during first time treatment. The proportion of patients experiencing at least one ADR during their first time treatment was 22.7% for ADA and 20.2% for ETN (p=0.628). Survival time to first ADR did not differ significantly between ADA and ETN (median survival ADA 10.34 years (95% CI [7.62-13.06], median survival ETN not reached, p=0.109, figure 1A). Median drug survival was 1.75 years for ADA (95 CI [1.38-2.11]) and 2.68 years for ETN (95% CI [1.73-3.64]). Drug survival differed significantly (p<0.001, figure 1B).Figure 1.Kaplan-Meier survival curves for adalimumab and etanercept with (a) survival to first ADR and (b) drug survival.Conclusion:Neither the proportion of patients experiencing ADRs nor survival to first ADR during first time treatment with ADA and ETN differed significantly. Drug survival of first time drug treatment of ADA was significantly lower compared to drug survival of first time drug treatment of ETN.Disclosure of Interests:My Nguyen: None declared, Kimberly Velthuis: None declared, Joep Scholl: None declared, Jurriaan Jansen: None declared, Leanne Kosse: None declared, Peter ten Klooster: None declared, Naomi Jessurun: None declared, Harald Vonkeman Consultant of: BMS, Celgene, Celltrion, Galapagos, Gilead, Janssen-Cilag, Lilly, Novartis, Pfizer, Sanofi-Genzyme, Grant/research support from: Abbvie

Kondisi Psikologis Mahasiswa PGSD Universitas Muhammadiyah Buton (UMB) dalam Pelaksanaan Pembelajaran Daring di Masa Pandemi

Pelaksanaan pembelajaran daring di masa pandemi memunculkan berbagai masalah bagi peserta didik termasuk keluhan kondisi psikologis, maka dari itu perlu dilakukan suatu penelitian untuk mendeteksi bagaimana kondisi psikologi mahasiswa selama penerapan pembelajaran daring. Jenis penelitian yang digunakan adalah metode penelitian kuantitatif dengan menggunakan metode Survey. Variabel penelitian yaitu keluhan psikologis dalam pelaksanaan pembelajaran daring dan mahasiswa PGSD Universitas Muhammadiyah Buton. Subyek penelitian ialah mahasiswa PGSD Universitas Muhammadiyah Buton (UM. Buton) yang dipilih dengan menggunakan teknik simple Random Sampling sehingga diperoleh 80 sampel penelitian. Hasil penelitian menunjukkan bahwa secara deskriptif bahwa mahasiswa mengalami keluhan psikologis dalam mengikuti pembelajaran daring dimasa pandemic, hal tersebut diukur menggunakan indikator psikologis. Adapun keluhan psikologis yang dialami oleh mahasiwa yakni; 77,5% mahasiswa bosan dan tidak bosan 22,5%, cemas 45% dan tidak cemas adalah 55%, stress 57,5% dan tidak stress 42,5%, resah 57,5% dan tidak resah ada 42,5%, pusing 73,8% dan tidak pusing ada 26,2% dan mahasiswa yang berharap agar pembelajaran daring segera berakhir ada 95% dan yang merasa tidak resah ada,5%. Kesimpulannya adalah terdapat keluhan psikologi yang dialami mahasiswa PGSD Universitas Muhammadiya Buton (UMB) dalam mengikuti pembelajaran daring di masa pendemi. Dengan hasil penelitian ini diharapkan pendidik lebih selektif dalam memilih metode dan sarana pembelajaran daring

A Software Development Model for the Automatic Generation of Classes

In this paper it is presented a software development model based on transformations that allows to derive, in an automatic way, classes in object-oriented programming languages (Ada 95, C++, Eiffel and Java) starting from formal specifications. The set of transformations that conforms the software development model are a systematic steps, which starts from the algebraic specification of a type. This algebraic specification describes the abstract behavior of a type (type of interest) by means of other type, previously specified and implemented (representation type). In a progressive way, the transformations steps allow get a program (class) nearby to the initial specification (type of interest). These transformations obtain -in the first step- an intermediate specification (class specification) that it describes the operations of the type of interest by means of pre and post-conditions. Then, the intermediate specification is used to obtain imperative code in language-independent notation (pseudo-class); and finally the pseudo-class is transformed to any object- oriented programming language for which it has been defined transformations.

Hubungan Pertambahan Berat Badan Ibu Hamil terhadap Berat Bayi Lahir di Kota Pariaman

AbstrakPertumbuhan janin intrauterin sangat menentukan berat bayi lahir. Banyak faktor yang dapat mempengaruhi berat bayi lahir, salah satunya adalah status gizi janin.Untuk mencapai status gizi yang diharapkan, ibu hamil harus mencapai penambahan berat badan yang ideal. Tujuan penelitian ini adalah untuk mengetahui hubungan pertambahan berat badan ibu hamil terhadap berat bayi lahir di kota Pariaman. Metode penelitian adalah analitik yang dilakukan di kota Pariaman dengan menggunakan data ibu melahirkan bulan Januari-Juni 2011. Ada 95 sampel yang digunakan dalam penelitian ini, didapatkan jumlah terbanyak pertambahan berat badan ibu pada range < 10 kg, yaitu sebanyak 39 orang dengan rerata 7,46 kg (± 1,274 SD) sedangkan berat badan yang >12,3 kg didapatkan 27 orang dengan rerata 17,39 kg (± 5,792 SD). Secara keseluruhan pertambahan berat badan ibu rerata dalam rentang normal, yaitu 11,29 kg (± 5,194 SD). Bayi dengan berat badan lahir rendah (≤ 2,5 kg) sebanyak 2 bayi (2,1%) dengan berat rerata 2,350 gram (± 0,2121 SD) sedangkan berat badan normal (>2,5 – 4 kg) adalah 92 bayi atau 96,8% dengan berat rerata 3,176 gram (± 0,3339 SD). Secara keseluruhan berat bayi lahir rratae yang didapatkan adalah 3,169 kg (± 0,3661 SD). Berdasarkan hasil uji korelasi, didapatkan r = 0,103 dan p = 0,323 (>0,05). Disimpulkan bahwa tidak ada hubungan signifikan antara pertambahan berat badan ibu hamil terhadap berat bayi lahirdi kota Pariaman.Kata kunci: pertambahan berat badan ibu hamil, berat bayi lahir, pertumbuhan janin intrauterin, status gizi janin AbstractThe intrauterine fetal growth is very affect the birth weight. Many factors that can affect birth weight is one of the nutritional status of the fetus. To achieve the expected nutritional status of pregnant, women have reached the ideal weight gain. The objective of this study was to determine the relationship of maternal weight gain on infant birth weight in Pariaman. The method of this study is analytical in Pariaman. Pregnant women’s data taken from January until June 2011.There were 95 samples used in this study.Obtained the highest number of maternal weight gain, we found that the average of birth weight, range < 10 kg, as many as 39 samples with an average 7.46 kg (± 1.274 SD), whereas sample with a weight gain of more than 12.53 kg as many as 27 samples with an average 17.39 kg (± 5.792 SD). Overall maternal weight gain in the average is normal, the average is 11.29 kg (± 5.194 SD). Obtained birth weight, infant with low birth weight (≤ 2.5 kg) as many as 2 samples (2.1%) with an average 2.350 kg (± 0.2121 SD) whereas sample withnormal birth weight (> 2.5 – 4 kg) as many as 92 samples,(96.8%)with weight in the average is normal, 3.176 gram (± 0.3339 SD). Overall birth weight int the average is normal, the average is 3.169 kg (± 0.3661 SD). Based on the test result showed that the correlation, r = 0.103 and p = 0.323 (> 0.05). It can be concluded that there is no significant relationship between maternal weight gain on infant birth weight in Pariaman.Keywords: maternal weight gain, birth weight, intrauterine fetal growth, nutritional status of the fetus