Stratigraphic templates for ice core records of the past 1.5 million years

The international ice core community has a target to obtain continuous ice cores stretching back as far as 1.5 million years. This would provide vital data (including a CO2 profile) allowing us to assess ideas about the cause of the Mid-Pleistocene Transition (MPT). The European Beyond EPICA project and the Australian Million Year Ice Core project each plan to drill such a core in the region known as Little Dome C. Dating the cores will be challenging, and one approach will be to match some of the records obtained with existing marine sediment datasets, informed by similarities in the existing 800 kyr period. Water isotopes in Antarctica have been shown to closely mirror deepwater temperature, estimated from Mg / Ca ratios of benthic foraminifera, in a marine core on the Chatham Rise near to New Zealand. The dust record in ice cores resembles very closely a South Atlantic marine record of iron accumulation rate. By assuming these relationships continue beyond 800 ka, our ice core record could be synchronised to dated marine sediments. This could be supplemented, and allow synchronisation at higher resolution, by the identification of rapid millennial scale-events that are observed both in Antarctic methane records and in emerging records of planktic oxygen isotopes and alkenone sea surface temperature (SST) from the Portuguese Margin. Although published data remain quite sparse, it should also be possible to match 10Be from ice cores to records of geomagnetic palaeointensity and authigenic 10Be/9Be in marine sediments. However, there are a number of issues that have to be resolved before the ice core 10Be record can be used. The approach of matching records to a template will be most successful if the new core is in stratigraphic order, but should also provide constraints on disordered records, if used in combination with absolute radiogenic ages.

Microstructure, micro-inclusions, and mineralogy along the EGRIP ice core – Part 1: Localisation of inclusions and deformation patterns

Impurities deposited in polar ice enable the reconstruction of the atmospheric aerosol concentration of the past. At the same time they impact the physical properties of the ice itself such as its deformation behaviour. Impurities are thought to enhance ice deformation, but observations are ambiguous due to a shortage of comprehensive microstructural analyses. For the first time, we systematically analyse micro-inclusions in polar fast flowing ice, i.e. from the East Greenland Ice Core Project ice core drilled through the Northeast Greenland Ice Stream. In direct relation to the inclusions we derive the crystal preferred orientation, fabric, grain size, and microstructural features at 10 depths, covering the Holocene and Late Glacial. We use optical microscopy to create microstructure maps to analyse the in situ locations of inclusions in the polycrystalline, solid ice samples. Micro-inclusions are more variable in spatial distribution than previously observed and show various distributional patterns ranging from centimetre-thick layers to clusters and solitary particles, independent of depth. In half of all samples, micro-inclusions are more often located at or close to the grain boundaries by a slight margin (in the areas occupied by grain boundaries). Throughout all samples we find strong indications of dynamic recrystallisation, such as grain islands, bulging grains, and different types of sub-grain boundaries. We discuss the spatial variability in micro-inclusions, the link between spatial variability and mineralogy, and possible effects on the microstructure and deformation behaviour of the ice. Our results emphasise the need for holistic approaches in future studies, combining microstructure and impurity analysis.

Teachers' Experiences in the Implementation of the Life Skills CAPS for Learners With Severe Intellectual Disability

This article focuses on a participatory process where the experiences of teachers regarding the implementation of the life skills curriculum and assessment policy statement (CAPS) for learners with severe intellectual disabilities (SID) in schools for learners with special educational needs were investigated. This curriculum for learners with SID has been developed to be more effective in meeting the needs of these learners. The curriculum ensures that learners can meet the requirements of the national CAPS used in ordinary public schools at a reduced depth and width, or at a more functional level, in accordance with their cognitive abilities. Although a descriptive mixed research method was applied in the study, this article reports on the qualitative part of the research. In the qualitative phase, collages and arts-based discussions with core project groups were used to generate data. Four schools, 13 core project groups, and 51 participants (teachers) were involved in the research. The transcribed data from the core project group discussions were analysed using thematic analysis, and the themes that emerged were discussed by the participants. Based on the results of these qualitative arts-based discussions, the findings were used to create opportunities for the teachers to talk and work together to jointly develop a training manual for beginner teachers and to form a learning environment that would permit rich inquiry-based dialogue among the teachers.

Discovery and Development of Pregabalin (Lyrica): The Role of Public Funding

Background:Pregabalin (Lyrica), a widely used drug that has generated billions in revenue as a treatment for diabetic neuropathy and other conditions, was originally discovered in an academic medical center, largely supported by public funding.Objective:To define the extent of direct federal public funding that contributed to various stages of pregabalin’s development prior to Food and Drug Administration (FDA) approval.Methods:We identified key research, scientists and organizations involved in the development of pregabalin from its discovery through FDA approval. Using key terms (e.g., its indications and mechanism of action), we searched PubMed for relevant publications and determined whether each publication was based on federal public funding, using the National Institutes of Health RePORTER. For each award prior to the drug’s FDA approval, we scored its potential relatedness to pregabalin’s development based on its title, investigator, and organization, and then examined descriptions of the most relevant awards to aid in defining these relationships. The budgets for all related awards were converted to 2020 dollars.Results:Pregabalin was discovered largely on the basis of publicly funded research at Northwestern University; in 1990, it was licensed to Parke-Davis which further developed it through its FDA approval in 2004. Most key terms were related to the drug and drug-target (n=5) and organizations involved (n=5), followed by patent-listed inventors (n=3). These key terms linked 6,438 core project awards, and we identified 37 NIH awards related to pregabalin’s development: 9 awards through 1990 ($3.3 million) and 28 from 1991-2004 ($10.5 million).Conclusions:Like many other widely-sold medications, the development of pregabalin relied on public-sector as well as industry contributions to its discovery, with relevant NIH awards totaling $13.8 million during its pre-approval development.

A portable lightweight in situ analysis (LISA) box for ice and snow analysis

There are enormous costs involved in transporting snow and ice samples to home laboratories for “simple” analyses in order to constrain annual layer thicknesses and identify accumulation rates of specific sites. It is well known that depositional noise, incurred from factors such as wind drifts, seasonally biased deposition and melt layers can influence individual snow and firn records and that multiple cores are required to produce statistically robust time series. Thus, at many sites, core samples are measured in the field for densification, but the annual accumulation and the content of chemical impurities are often represented by just one core to reduce transport costs. We have developed a portable “lightweight in situ analysis” (LISA) box for ice, firn and snow analysis that is capable of constraining annual layers through the continuous flow analysis of meltwater conductivity and hydrogen peroxide under field conditions. The box can run using a small gasoline generator and weighs less than 50 kg. The LISA box was tested under field conditions at the East Greenland Ice-core Project (EastGRIP) deep ice core drilling site in northern Greenland. Analysis of the top 2 m of snow from seven sites in northern Greenland allowed the reconstruction of regional snow accumulation patterns for the 2015–2018 period (summer to summer).

Key Drivers for Adopting Design-Build in Public Construction Projects: Malaysian Perspective

Design-build (D-B) had been applied in many advanced countries because the delivery method improves construction project success. While several megaprojects in Malaysia have adopted D-B, it is still uncommon in the local construction industry. Therefore, understanding the key drivers that are affecting the acceptance or rejection of D-B is crucial. However, that information is lacking in the existing body of knowledge. Thus, this research addresses that issue by identifying the key drivers for adopting D-B in the Malaysian construction sector from the standpoint of the core project parties (e.g., project clients, consultants and contractors). Questionnaire survey data from 111 professionals with D-B experience were analysed using inferential statistics, including t-test and analysis of variance (ANOVA). The outcome shows that the key drivers for industry practitioner in Malaysia for adopting D-B are: (1) "Maximise the use of resources between project team members", (2) "Sharing of expertise (design and technical) with project team members", (3) "Well-organised project team structure", (4) "High success rate" and (5) "Dispute prevention during the construction stage". Also, there are no significant differences found in the drivers between different geographical regions and project parties. Based on the investigations, this study adds to the current assortment of information in capturing the key drivers and providing an in-depth understanding of the underlying components for adopting D-B in Malaysia. Researchers and industry practitioners can use the findings to enhance the level of D-B adoption strategically.

Microstructure, Micro-inclusions and Mineralogy along the EGRIP ice core – Part 1: Localisation of inclusions and deformation patterns

Impurities deposited in polar ice allow the reconstruction of the atmospheric aerosol concentration of the past. At the same time they impact the physical properties of the ice itself such as its deformation behaviour. Impurities are thought to enhance ice deformation, but observations are ambiguous due to a shortage of comprehensive microstructural analyses. For the first time, we systematically analyse micro-inclusions in polar fast flowing ice, i.e. from the East Greenland Ice Core Project ice core drilled trough the Northeast Greenland Ice Stream. In direct relation to the inclusions we derive the crystal-preferred orientation, fabric, grain size, and microstructural features at ten depths, covering the Holocene and Late Glacial. We use optical microscopy to create microstructure maps to analyse the in situ locations of inclusions in the polycrystalline, solid ice samples. Micro-inclusions are more variable in spatial distribution than previously observed, and show various distributional patterns ranging from centimetre-thick layers to clusters and solitary particles, independent of depth. Analysing the area occupied by grain boundaries in the respective samples shows that micro-inclusions are slightly more often located at or close to grain boundaries in half of all samples. Throughout all samples we find strong indications of dynamic recrystallisation, such as grain islands, bulging grains and different types of subgrain boundaries. We discuss the spatial variability of micro-inclusions, the link between spatial variability and mineralogy, and possible effects on the microstructure and deformation behaviour of the ice. Our results emphasise the need for holistic approaches in future studies, combining microstructure and impurity analysis.

Microstructure, Micro-inclusions and Mineralogy along the EGRIP ice core – Part 2: Implications for paleo-mineralogy

Impurities in polar ice do not only allow the reconstruction of past atmospheric aerosol concentration, but also in- fluence the physical properties of the ice. However, the mineralogy and location of impurities in ice and the involved processes are poorly understood. We use Continuous Flow Analysis to derive the dust particle concentration and optical microscopy and Cryo-Raman spectroscopy to systematically locate and analyse the mineralogy of micro-inclusions in situ inside eleven solid ice samples from the upper 1340 m of the East Greenland Ice Core Project ice core. Micro-inclusions are more variable in min- eralogy than previously observed and are mainly composed of mineral dust (quartz, mica and feldspar) and sulphates (mainly gypsum). Inclusions of the same composition tend to cluster, but clustering frequency and mineralogy changes considerably with depth. A variety of sulphates dominate the upper 900 m while gypsum is the only sulphate in deeper samples, which however contain more mineral dust, nitrates and dolomite. The analysed part of the core can thus be divided into two depth regimes of different mineralogy, and to a lesser degree of spatial distribution, which could originate from different chemical reactions in the ice or large-scale changes of ice cover in NE-Greenland during the Mid-Holocene. The complexity of impurity mineralogy on the metre- and centimetre-scale in polar ice is still underestimated and new methodological approaches are necessary to establish a comprehensive understanding of the role of impurities.

Safe Local Aerial Manipulation for the Installation of Devices on Power Lines: AERIAL-CORE First Year Results and Designs

The power grid is an essential infrastructure in any country, comprising thousands of kilometers of power lines that require periodic inspection and maintenance, carried out nowadays by human operators in risky conditions. To increase safety and reduce time and cost with respect to conventional solutions involving manned helicopters and heavy vehicles, the AERIAL-CORE project proposes the development of aerial robots capable of performing aerial manipulation operations to assist human operators in power lines inspection and maintenance, allowing the installation of devices, such as bird flight diverters or electrical spacers, and the fast delivery and retrieval of tools. This manuscript describes the goals and functionalities to be developed for safe local aerial manipulation, presenting the preliminary designs and experimental results obtained in the first year of the project.