The four noble truths are the foundation of all of Buddhist thought, and especially ethical thought. This chapter examines Buddhist insight into the ways that suffering pervades every aspect of our lives, and the importance of the many different levels of suffering, including suffering from shame, suffering of change, and suffering of pervasive conditioning. The chapter also covers the Buddhist account of the origins of suffering, from the three pathologies of primal confusion, attraction, and aversion. Finally, it addresses the aspects of the eightfold path, and its applications as a way to attain the cessation of these forms of suffering.