A novel thermoplastic elastomer was applied in the measurement of extravehicular liquid cooling garment and the satisfying result in improving the heat dissipating capacity of liquid cooling garment was achieved. Firstly, five kinds of elastomer were selected, which were ethylene-vinyl acetate copolymer (EVA), high temperature vulcanized silicone rubber (HTV), medical used silicon rubber (MSR), natural rubber latex (NRL) and thermoplastic SBS complex (TPR). To evaluate the synthetic performance of these materials, a series of experiments characterizing material’s mechanical and thermodynamic properties was performed, including tensile and compression test, heat property test and so on. Meanwhile, fuzzy mathematic method was employed to get parameters’ weight distribution, and then fuzzy decision-making method was adopted to perform synthetic evaluation, which showed that TPR had satisfying optimization performance and can be used as simulated skin in thermal manikin. Finally, to verify the function of TPR simulated skin, comparative experiments were performed in climate chamber when thermal manikin covered with TPR simulated skin and did not cover with TPR simulated skin. Results show that TPR simulated skin can effectively improve the heat dissipating capacity of liquid cooling garment.