Infiltrating Ductal Breast Carcinoma Metastasized to the Rectum: A Case Report and a Review of the Literature

BACKGROUND:Gastrointestinal (GI) metastasis in breast cancer (BC) is uncommon, although in the rare cases when it occurs, infiltrating lobular carcinoma is the most commonly reported pathological subtype. Nonetheless, gastrointestinal metastasis from infiltrating ductal breast carcinoma is extremely rare and usually occurs several years after the appearance of the primary tumor. The present study was, to the best of our knowledge, the first one to present a case of distal rectum metastasis originating from infiltrating ductal breast carcinoma. CASE PRESENTATION:The present report discusses the case of a Chinese female patient aged 37 years. The patient presented with diarrhea along with bloody stools and anal bearing-down pain. Earlier in 2015, she had undergone axillary lymph node dissection (LND) and right modified radical mastectomy in another hospital to treat the infiltrating ductal breast carcinoma pT1N1M0. The presented symptoms were investigated by performing colonoscopy, which indicated lower rectal swelling at 3 cm on the top of the anal verge. Further investigation with positron emission tomography-computed tomography (PET-CT) revealed an uptake of fluorodeoxyglucose (FDG) within the distal rectum as well as in the left acetabulum. The samples from laparoscopic exploration were biopsied, which revealed metastases of breast cancer. Therefore, the patient was intraoperatively diagnosed with the rectal metastasis of BC and was treated with laparoscopic radical abdominoperineal resection. Furthermore, the immunohistochemical analysis of the tumor confirmed that the patient had the rectal metastasis of infiltrating ductal BC. CONCLUSION:Rectal metastasis should be considered when breast cancer patients present with a complaint of changed bowel habits, even for those with a history of ductal breast cancer.

Anorectal anomalies in the male: revisiting the radiological classification

Background Classifying anorectal anomalies (ARA) has always been a matter of debate among pediatric surgeons. A new classification does not necessarily imply discarding older ones. Several concepts have been introduced in the past and stood the test of time being still valid up till now In this report, we present our experience in managing a group of boys with ARA by PSARP. We have tried to enhance the current classification to include information about the level of the rectum in relation to sacrum, not just the location of the fistula. Results The study included 62 consecutive male patients with anorectal anomalies who underwent PSARP between 2009 and 2019. Included cases were either recto-bulbar fistula (21 cases), recto-prostatic fistula (30 cases), or imperforate anus without fistula (11 cases). Their age at operation ranged from 3 to 36 months (mean 7.8 months). Cases with recto-prostatic fistula were further subclassified according to the level of distal rectum into two subgroups: (type 1) those with the rectum ending opposite the level of S4/S5, and (type 2) those with the rectum ending at a higher level opposite S3. The PSARP procedure proved to be a successful surgical approach to reach, separate, and mobilize the rectum in all cases of recto-bulbar fistula, imperforate anus without fistula, and recto-prostatic fistula type (1). In cases of recto-prostatic fistula type (2), the perineal approach (PSARP) failed to reach and mobilize the rectum in two out of the eleven cases. Conclusion In management of anorectal anomalies, the sacrum can provide two important indicators: a prognostic value for continence, and anatomical landmark to stratify the level of distal rectum in the pelvis which is crucial for planning the best surgical approach.

Accuracy Of Transperineal Sonography And Distal Loopogram In Determining Distal Rectal Pouch-Perineal Distance And Fistula On Anorectal Malformation Post Colostomy Patients At Dr. Mohammad Hoesin Palembang

Background : Imperforated anus is a congenital abnormality which is better known as anorectal malformation. The incidence of anorectal malformations is 1 in 4000 to 5000 live births. The incidence of anorectal malformations in Europe varies from 1.14 to 5.96 per 10,000 people and can change each year.1-3 The surgical approach in the management of anorectal malformations depends on the classification of anorectal malformations based on low, intermediate and high location. The distal loopogram or distal colostrography / colostrogram examination is an examination that is very important to determine the location of the distal rectum before definitive repair, but this examination has the disadvantage of using contrast and x-ray radiation. One alternative radiological examination that can be used for faster initial management is sonographic.7 Method : This study was a diagnostic test study to assess the diagnostic accuracy of the distal loopogram / colostrography examination and sonographic examination with the transperineal approachon post-colostomy Anorectal Malformations patients at Mohammad Hoesin Hospital, Palembang in August 2019-October 20120 or until the number of research samples is met. Result : There were 21 samples in this study, 11 (52.4%) samples were dominated by clinical appearance without fistula. On the results of ultrasound examination, the majority of samples of rectouretral fistulas were 7 (33.3%). Loopogram examination found the majority of samples without fistulas as many as 10 (47.6%) samples. On intraoperative examination, 7 (33.3%) samples were obtained for rectouretral fistulas. The result of pouch-perineum measurement on ultrasound examination was 1.15 ± 0.6 cm, loopogram was 0.7 ± 1.5 cm, intra-operasionem was 1.8 ± 1.6 cm. In this study, USG has a very high accuracy value with a sensitivity of 100% and a specificity of 93.8% while the Loopogram has a sensitivity of 100% and a specificity of 68.8%. Conclusion : Transperineal ultrasound has a very high accuracy value with a sensitivity of 100% and a specificity of 93.8% while the Loopogram has a sensitivity of 100% and a specificity of 68.8%. Although there is a significant difference between the distal rectum -perineal distance calculation with a difference of -0.38 ± 0.70 cm, these two methods are equally accurate in assessing the distal rectal pouch -perineal distance and the location of the fistula.

PROFIL PENDERITA HEMOROID DI RUMAH SAKIT ISLAM SITI RAHMAH PADANG SUMATERA BARAT PERIODE 2016-2017

Hemoroid (wasir) merupakan pelebaran pleksus vaskular arteri vena yang mengelilingi bagian distal rectum dan kanal anal. Namun, kebanyakan masyarakat kurang tahu mengenai gejala-gejalanya. Data Dinas Kesehatan Provinsi Sumatera Selatan menyatakan penderita penyakit Hemoroid pada tahun 2009 sebanyak 424 orang, tahun 2010 sebanyak 427 penderita dan tahun 2011 sebanyak 436 orang penderita. Penelitian ini bertujuan untuk mengetahui profil penderita hemoroid di rumah Sakit Islam Siti Rahmah Padang periode 2016 - 2017 dengan menggunakan penelitian deskriptif dengan menggunakan data sekunder yang berasal dari rekam medis dan data primer dari wawancara pasien. Sampel dari penelitian ini diambil dari data rekam medis seluruh pasien hemoroid yang memenuhi kriteria inklusi. Data diambil dengan menggunakan metode “Simple Random Sampling”. Hasil penelitian menunjukan bahwa kelompok usia tertinggi adalah kelompok usia 15-44 tahun (60%), jenis kelamin terbanyak laki laki (57,8%), klasifikasi hemoroid interna (88,9%), derajat III dan IV yang masing-masingnya (32,2%), keluhan nyeri (100%) diikuti benjolan (97,77%), posisi defekasi duduk (55,5%), riwayat konstipasi (95,6%). Kata kunci: Usia, jenis kelamin, klasifikasi, derajat, riwayat, posisi defekasi dan konstipiasi

Infra-anastomotic Innervation of Residual Aganglionic Distal Rectum After Pull-through Surgery for Hirschsprung Disease

Background Descending neurons are important for intestinal reflex activities, including the recto-anal inhibitory reflex involved in normal defecation. Pull-through surgery for Hirschsprung disease results in the anastomosis of ganglionic bowel to native aganglionic rectum just superior to the internal anal sphincter, which potentially could allow for physiologically significant infra-anastomotic innervation. Methods The density and distribution of intramuscular neuronal nitric oxide synthase (nNOS)- and mucosal calretinin-immunoreactive nerves were evaluated proximal and distal to the anastomosis in redo resection specimens after pull-through surgery for Hirschsprung disease. The findings were compared with data collected from cadaveric controls with no history of dysmotility and the distal aganglionic segments of primary rectal resections from patients with Hirschsprung disease. Results Native aganglionic rectum of Hirschsprung patients lacks the normal lush intramuscular nNOS- and mucosal calretinin-immunoreactive nerves present in normal bowel. In post-pull-through resection specimens obtained more than 7 months after pull-through surgery, nNOS- and calretinin-positive innervation is at least partially restored for variable distances up to 10 to 12 mm inferior to the anastomosis, respectively. Conclusions Innervation of infra-anastomotic muscularis propria and mucosa in the aganglionic distal rectum occurs to a variable degree after pull-through surgery for Hirschsprung disease and may contribute to individual differences in postoperative obstructive symptoms. Strategies to enhance infra-anastomotic innervation may improve clinical outcome.

Ambulatory Surgery for Perianal Crohn’s Disease: Study of Feasibility

Background. One-third of Crohn’s disease (CD) patients present perianal fistula. The gold standard in the diagnosis and treatment of symptomatic perianal disease (PAD) in CD is the exploration of the anal canal and distal rectum under anesthesia (EUA). This procedure is mainly conducted as a day case surgery. Unfortunately, it is not always possible to proceed within the ideal timing and any delay may well represent a relevant clinical issue. The aim of this study was to evaluate the feasibility of outpatient treatment of symptomatic perianal fistulas in CD patients. Methods. All CD patients under regular follow-up at our inflammatory bowel disease referral center, presenting with symptomatic perianal fistulas, were offered surgical consultation. The data of patients were prospectively collected for three years (February 2014 to February 2017) for the purpose of the study. All clinical information, including previous EUA and/or records from MRI and endoscopic ultrasound, was included. Outpatient anal canal and distal rectum exploration and treatment (OE) were undertaken during the specialist surgical consultation. Fistulas were classified according to Parks’s classification; the type of outpatient treatment and compliance of patients were recorded. Pain was assessed by VAS at the time of the procedure and during the first control. Patients were followed up in the surgical clinic in relation to the study. Results. Ninety-two CD patients with symptomatic perianal fistulas had surgical consultation during the study period. OE was offered to all but 18 patients who fulfilled the exclusion criteria or had an extremely severe disease; six patients refused the OE (8.11%). Of the 68 patients undergoing OE, eleven (16.18%) had previous surgery for perianal disease. The OE was accomplished in sixty-one patients (89.71%), while in 7 patients, it was abandoned for scarce compliance. Nine patients (14.75%) underwent drainage of perianal abscess; in 3 of them, it was possible to probe the fistula tract, find the internal orifice, and pass a loose seton. Overall, setonage was performed in 50 patients (81.97%). Rectovaginal setons were placed in 3 patients and more than one seton (up to 3) in 6 cases. Fistulotomy was performed in 4 simple subcutaneous fistulous tracts. Concordance with the preoperative findings was found in 54 out of 61 patients. EUA was scheduled at the time of OE for the 7 patients who did not complete the procedure. All sixty-one patients who had the OE were followed up for a minimum of 12 months. Conclusions. This preliminary study indicates that OE in CD patients with symptomatic perianal fistulas is safe and feasible in a high-volume referral center. It might provide several benefits, including patients’ logistics, reduce or remove patients’ symptoms and discomfort, allow for a timely start of medical therapy, and avoid further complications.