microfluidic technology
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2022 ◽  
Vol 13 ◽  
pp. 100205
Author(s):  
Akhilesh Bendre ◽  
Mahesh P. Bhat ◽  
Kyeong-Hwan Lee ◽  
Tariq Altalhi ◽  
Mohammed Ayad Alruqi ◽  
...  

Soft Matter ◽  
2022 ◽  
Author(s):  
Tatiana Porto Santos ◽  
Cesare Mikhail Cejas ◽  
Rosiane Lopes da Cunha

Microfluidic technology enables a judicious control of the process parameters on a small length-scale, which in turn allows speeding up the destabilization of emulsion droplets interface in microfluidic devices. In...


ACS Omega ◽  
2021 ◽  
Author(s):  
Yu Qin ◽  
Xinyu Lu ◽  
Han Que ◽  
Dandan Wang ◽  
Tao He ◽  
...  

Cancers ◽  
2021 ◽  
Vol 13 (23) ◽  
pp. 6052
Author(s):  
Hongyan Xie ◽  
Jackson W. Appelt ◽  
Russell W. Jenkins

Recent advances in cancer immunotherapy have led a paradigm shift in the treatment of multiple malignancies with renewed focus on the host immune system and tumor–immune dynamics. However, intrinsic and acquired resistance to immunotherapy limits patient benefits and wider application. Investigations into the mechanisms of response and resistance to immunotherapy have demonstrated key tumor-intrinsic and tumor-extrinsic factors. Studying complex interactions with multiple cell types is necessary to understand the mechanisms of response and resistance to cancer therapies. The lack of model systems that faithfully recapitulate key features of the tumor microenvironment (TME) remains a challenge for cancer researchers. Here, we review recent advances in TME models focusing on the use of microfluidic technology to study and model the TME, including the application of microfluidic technologies to study tumor–immune dynamics and response to cancer therapeutics. We also discuss the limitations of current systems and suggest future directions to utilize this technology to its highest potential.


2021 ◽  
Vol 2119 (1) ◽  
pp. 012067
Author(s):  
M I Pryazhnikov ◽  
A V Minakov ◽  
A I Pryazhnikov ◽  
I A Denisov ◽  
A S Yakimov ◽  
...  

Abstract This paper presents the results of testing microfluidic technology for oil displacement problems using cheap and quickly manufactured chips made of polymethylmethacrylate (PMMA) by milling. The oil displacement process from a microfluidic chip simulating a homogeneous porous medium is studied. The microfluidic chip was manufactured by milling of polymethylmethacrylate. The size of the microchannels was 200 microns. The paper presents the results of visualization and microscopy of the oil displacement process. The effect of water flow on the efficiency of oil displacement from the microfluidic chip was studied.


2021 ◽  
Author(s):  
Ping Ye ◽  
Yizhou Yang ◽  
Bo Su ◽  
Cunlin Zhang

Foods ◽  
2021 ◽  
Vol 10 (11) ◽  
pp. 2646
Author(s):  
Yuanhang Yao ◽  
Jiaxing Jansen Lin ◽  
Xin Yi Jolene Chee ◽  
Mei Hui Liu ◽  
Saif A. Khan ◽  
...  

Inadequate intake of lutein is relevant to a higher risk of age-related eye diseases. However, lutein has been barely incorporated into foods efficiently because it is prone to degradation and is poorly bioaccessible in the gastrointestinal tract. Microfluidics, a novel food processing technology that can control fluid flows at the microscale, can enable the efficient encapsulation of bioactive compounds by fabricating suitable delivery structures. Hence, the present study aimed to evaluate the stability and the bioaccessibility of lutein that is encapsulated in a new noodle-like product made via microfluidic technology. Two types of oils (safflower oil (SO) and olive oil (OL)) were selected as a delivery vehicle for lutein, and two customized microfluidic devices (co-flow and combination-flow) were used. Lutein encapsulation was created by the following: (i) co-flow + SO, (ii) co-flow + OL, (iii) combination-flow + SO, and (iv) combination-flow + OL. The initial encapsulation of lutein in the noodle-like product was achieved at 86.0 ± 2.7%. Although lutein’s stability experienced a decreasing trend, the retention of lutein was maintained above 60% for up to seven days of storage. The two types of device did not result in a difference in lutein bioaccessibility (co-flow: 3.1 ± 0.5%; combination-flow: 3.6 ± 0.6%) and SO and OL also showed no difference in lutein bioaccessibility (SO: 3.4 ± 0.8%; OL: 3.3 ± 0.4%). These results suggest that the types of oil and device do not affect the lutein bioaccessibility. Findings from this study may provide scientific insights into emulsion-based delivery systems that employ microfluidics for the encapsulation of bioactive compounds into foods.


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