<p>In radiative-convective equilibrium (RCE) simulations, convective self-aggregation (CSA) is the spontaneous organization into segregated cloudy and cloud-free regions. Evidence exists for how CSA is stabilized, but how it arises favorably on large domains is not settled. Using large-eddy simulations (LES), we link the spatial organization emerging from the interaction of cold pools (CPs) to CSA. We systematically weaken simulated rain evaporation to reduce maximal CP radii, <em>R</em><sub>max</sub>, and find reducing <em>R</em><sub>max</sub> causes CSA to occur earlier. We further identify a typical rain cell generation time and a minimum radius, <em>R</em><sub>min</sub>, around a given rain cell, within which the formation of subsequent rain cells is suppressed. Incorporating <em>R</em><sub>min</sub> and <em>R</em><sub>max</sub>, we propose a toy model that captures how CSA arises earlier on large domains: when two CPs of radii <em>r</em><sub><em>i</em>,<em>j </em></sub>&#8712; [<em>R</em><sub>min</sub>, <em>R</em><sub>max</sub>] collide, they form a new convective event. These findings imply that CPs play a crucial role in RCE simulations by preventing the onset of CSA.</p>