Prevalence and mortality of COVID-19 are associated with the L55M functional polymorphism of Paraoxonase 1

Introduction Accumulating evidence recommends that infectious diseases including coronavirus disease 2019 (COVID-19) are often associated with oxidative stress and inflammation. Paraoxonase 1 ( PON1, OMIM: 168,820), a member of the paraoxonase gene family, has antioxidant properties. Enzyme activity of paraoxonase depends on a variety of influencing factors such as polymorphisms of PON1, ethnicity, gender, age, and a number of environmental variables. The PON1 has two common functional polymorphisms, namely, Q192R (rs662) and L55M (rs854560). The R192 and M55 alleles are associated with increase and decrease in enzyme activity, respectively. Objective The present study was conducted to investigate the possible association of rs662 and rs854560 polymorphisms with morbidity and mortality of COVID-19. Methods Data for the prevalence, mortality, and amount of accomplished diagnostic test (per 106 people) on 25 November 2020 from 48 countries were included in the present study. The Human Development Index (HDI) was used as a potential confounding variable. Results The frequency of M55 was positively correlated with the prevalence (partial r = 0.487, df = 36, p = 0.002) and mortality of COVID-19 (partial r = 0.551, df = 36, p < 0.001), after adjustments for HDI and amount of the accomplished diagnostic test as possible confounders. Conclusions This means that countries with higher M55 frequency have higher prevalence and mortality of COVID-19.

Trajectories of boredom in self-control demanding tasks

Self-control does not always work effectively. Whether this reflects the depletion of a global self-control resource is subject to an ongoing debate. We turned to boredom as a potential confounding variable to advance this debate. In a high-powered experiment (N = 719), participants worked on a primary (transcription) tasks of varying self-control demands (low, high) and length (2, 4, 8 minutes), followed by a secondary (Stroop) task with low and high self-control demanding trials. In addition to trait boredom, we measured self-control investments (effort), self-control costs (difficulty, tiredness, frustration), and boredom after the primary task and repeatedly during the secondary task. Self-control investments and costs increased with the demand and duration of the primary task; however, without affecting performance in the secondary task. Importantly, participants rated both the primary and the secondary task as boring, and higher boredom at the state and the trait level was associated with lower self-control investments and higher self-control costs. During the secondary task, boredom increased steadily but was generally lower in more self-control demanding trials. Finally, boredom predicted performance in the secondary task. These results show an intricate relationship between self-control and boredom that research on these two constructs should carefully disentangle.

A Review of Depth of Focus in Measurement of the Amplitude of Accommodation

The aim of this review is to investigate the role of depth of focus (DoF) as a potential confounding variable in the measurement of the amplitude of accommodation (AoA). The role of DoF in human vision is briefly summarised, and it is noted that the prevalent method of measuring AoA is the push-up method. Factors influencing the effect of DoF on the push-up and other methods of measuring AoA are reviewed in detail. DoF is shown to add substantial measurement error in the routine assessment of accommodation when the AoA is measured by methods involving subjective judgement of an object’s clarity. Reliable compensation for this source of error is not realistically possible because of the complexity of the aetiology of DoF, and its inter-individual and intra-individual variation. The method of measurement also influences the extent of the error. It is concluded that methods of measurement of AoA that exclude DoF should be preferred.

Sex differences in post-stroke aphasia rates are caused by age. A meta-analysis and database query

BackgroundStudies have suggested that aphasia rates are different in men and women following stroke. One hypothesis says that men have more lateralized language function than women. Given unilateral stroke, this would lead to a prediction of men having higher aphasia rates than women. Another line of observations suggest that women are more severely affected by stroke, which could lead to a higher aphasia rate among women. An additional potential confounding variable could be age, given that women are typically older at the time of stroke.Methods & ProceduresThis study consists of two parts. First, a meta-analysis of the available reports of aphasia rates in the two sexes was conducted. A comprehensive literature search yielded 25 studies with sufficient information about both aphasia and gender. These studies included a total of 48,362 stroke patients for which aphasia rates were calculated. Second, data were extracted from an American health database (with 1,967,038 stroke patients), in order to include age and stroke severity into a regression analysis of sex differences in aphasia rates.Outcomes & ResultsBoth analyses revealed significantly larger aphasia rates in women than in men (1.1-1.14 ratio). This speaks against the idea that men should be more lateralized in their language function. When age and stroke severity were included as covariates, sex failed to explain any aphasia rate sex difference above and beyond that which is explained by age differences at time of stroke.

Comment on “The Influence of Risk Assessment Instrument Scores on Evaluators’ Risk Opinions and Sexual Offender Containment Recommendations”

The work of the Colorado Sex Offender Management Board (SOMB) has been called into question as a result of the manuscript “The Influence of Risk Assessment Instrument Scores on the Evaluators’ Risk Opinions and Sexual Offender Containment Recommendations” published in Criminal Justice and Behavior (2017). This response covers the following areas: significant nomenclature problems used to describe the Adult Standards and Guidelines, the dated nature of the SOMB citations in the manuscript, the flaws in the interpretation of the use of the 17 SOMB risk factors and the SOMB policy related to risk assessment, a potential confounding variable that may explain the results obtained, and finally the work of the SOMB to foster the use of validated risk assessment instruments and evidence-based policies and practices. The SOMB takes pride in providing up-to-date, research-supported practices for its providers and would never intentionally do otherwise, as suggested by the article.

Two-year citations of JAPPL original articles: evidence of a relative age effect

Several indicators have been used to analyze scientific journals, with the impact factor and the number of citations in a 2-yr calendar time frame (2-YRC) being the most common factors. However, considering that the Journal of Applied Physiology (JAPPL) appears monthly and that calculations of these indicators are based on citations of papers published in previous years, we hypothesized that articles published at the beginning of the year would be cited more in the 2-YRC compared with those appearing in the last issues of the year, a phenomena known as a relative age effect. Our objective was to confirm the existence of a relative age effect in the 2-YRC for original articles published in JAPPL. From 2005 to 2008, a total of 1,726 original articles were published, according to the Web of Science, and 9,973 citations in 2-YRC, varying from 0 to 45, with a mean of 5.78 for individual papers. Although there were no differences in the number of original articles published in a given month ( P = 0.99), the 2-YRC varied considerably throughout the year, being higher for those earlier issues of the year, as shown by the linear regression analysis ( r2 = 0.76; P < 0.001). The 2-YRC began at 6.62 during the first 3 mo of the year, dropping by 10% at each 3-mo period. In summary, the longer an article has been out there, the more citations it collects. The relative age effect is a potential confounding variable for the assessment and interpretation of 2-YRC (using calendar years) from JAPPL original articles.