Prevalence and mortality of COVID-19 are associated with the L55M functional polymorphism of Paraoxonase 1

Proceedings of Singapore Healthcare ◽

10.1177/20101058211040582 ◽

2021 ◽

pp. 201010582110405

Author(s):

Mostafa Saadat

Keyword(s):

Enzyme Activity ◽

Diagnostic Test ◽

Human Development Index ◽

Environmental Variables ◽

Antioxidant Properties ◽

Paraoxonase 1 ◽

Functional Polymorphism ◽

Confounding Variable ◽

Functional Polymorphisms ◽

Potential Confounding Variable

Introduction Accumulating evidence recommends that infectious diseases including coronavirus disease 2019 (COVID-19) are often associated with oxidative stress and inflammation. Paraoxonase 1 ( PON1, OMIM: 168,820), a member of the paraoxonase gene family, has antioxidant properties. Enzyme activity of paraoxonase depends on a variety of influencing factors such as polymorphisms of PON1, ethnicity, gender, age, and a number of environmental variables. The PON1 has two common functional polymorphisms, namely, Q192R (rs662) and L55M (rs854560). The R192 and M55 alleles are associated with increase and decrease in enzyme activity, respectively. Objective The present study was conducted to investigate the possible association of rs662 and rs854560 polymorphisms with morbidity and mortality of COVID-19. Methods Data for the prevalence, mortality, and amount of accomplished diagnostic test (per 106 people) on 25 November 2020 from 48 countries were included in the present study. The Human Development Index (HDI) was used as a potential confounding variable. Results The frequency of M55 was positively correlated with the prevalence (partial r = 0.487, df = 36, p = 0.002) and mortality of COVID-19 (partial r = 0.551, df = 36, p < 0.001), after adjustments for HDI and amount of the accomplished diagnostic test as possible confounders. Conclusions This means that countries with higher M55 frequency have higher prevalence and mortality of COVID-19.

Download Full-text

PP-209: PARAOXONASE 1 ENZYME ACTIVITY IN METABOLIC SYNDROME PATIENTS WITHOUT CORONARY ARTERY DISEASE

International Journal of Cardiology ◽

10.1016/s0167-5273(11)70408-9 ◽

2011 ◽

Vol 147 ◽

pp. S148

Author(s):

E. Yucel ◽

A. Aydinlar ◽

A. Aydin Kaderli ◽

T. Senturk ◽

S. Gunay ◽

...

Keyword(s):

Coronary Artery Disease ◽

Metabolic Syndrome ◽

Enzyme Activity ◽

Coronary Artery ◽

Paraoxonase 1 ◽

Artery Disease

Download Full-text

Paraoxonase-1 enzyme activity in rheumatoid arthritis patients: association with carotid intima-media thickness?

Menoufia Medical Journal ◽

10.4103/mmj.mmj_5_16 ◽

2020 ◽

Vol 33 (1) ◽

pp. 82

Author(s):

AlyM El-Kholy ◽

SabryA Shoeib ◽

AhmedR Tawfeek ◽

WaleedM Fathy ◽

MohamedZ Nouh

Keyword(s):

Rheumatoid Arthritis ◽

Enzyme Activity ◽

Intima Media Thickness ◽

Carotid Intima Media Thickness ◽

Paraoxonase 1 ◽

Media Thickness

Download Full-text

Sitagliptin-Dependent Differences in the Intensity of Oxidative Stress in Rat Livers Subjected to Ischemia and Reperfusion

Oxidative Medicine and Cellular Longevity ◽

10.1155/2019/2738605 ◽

2019 ◽

Vol 2019 ◽

pp. 1-10

Author(s):

Małgorzata Trocha ◽

Małgorzata Krzystek-Korpacka ◽

Anna Merwid-Ląd ◽

Beata Nowak ◽

Małgorzata Pieśniewska ◽

...

Keyword(s):

Oxidative Stress ◽

Rat Liver ◽

Ischemia Reperfusion ◽

Antioxidant Properties ◽

Thiobarbituric Acid ◽

Treated Group ◽

Paraoxonase 1 ◽

Pon1 Activity ◽

Tbars Level ◽

Rat Livers

Purpose. Ischemia/reperfusion (IR) is the main cause of liver damage after transplantation. We evaluated the effect of sitagliptin (STG) on oxidative stress parameters in the rat liver under IR. Methods. Rats were treated with STG (5 mg/kg) (S and SIR) or saline solution (C and CIR). Livers from CIR and SIR were subjected to ischemia (60 min) and reperfusion (24 h). During reperfusion, aminotransferases (ALT and AST) were determined in blood samples. Thiobarbituric acid reactive substances (TBARS), superoxide dismutase (SOD), catalase (CAT), paraoxonase-1 (PON1), glutathione peroxidase (GPx), and the mRNA expression of SOD1 were determined in liver homogenates after reperfusion. Different regions of livers were also histologically evaluated. Results. The PON1 activity was higher, and the TBARS level was lower in SIR than in CIR. There was an inverse relationship between TBARS and PON1 levels in the whole cohort. The GPx activity was lower in ischemic than in nonischemic groups regardless of the STG treatment. In SIR, the SOD1 activity was higher compared to that in CIR. In S, the expression of SOD1 mRNA was the highest of all examined groups and positively correlated with the SOD1 activity in the whole animal cohort. During IR aminotransferases, the activity in the drug-treated group was lower in all examined points of time. In drug-treated groups, the percentage of steatosis was higher than that in nontreated groups regardless of IR. Conclusions. The protective effect of STG on the rat liver, especially its antioxidant properties, was revealed under IR conditions.

Download Full-text

HDL subfraction distribution of paraoxonase-1 and its relevance to enzyme activity and resistance to oxidative stress

The Journal of Lipid Research ◽

10.1194/jlr.m700439-jlr200 ◽

2008 ◽

Vol 49 (6) ◽

pp. 1246-1253 ◽

Cited By ~ 28

Author(s):

Xenia Moren ◽

Sara Deakin ◽

Ming-Lin Liu ◽

Marja-Riitta Taskinen ◽

Richard W. James

Keyword(s):

Oxidative Stress ◽

Enzyme Activity ◽

Paraoxonase 1

Download Full-text

Association between Paraoxonase 1(PON1) Gene Polymorphisms and PON1 Enzyme Activity in Indian Patients with Coronary Artery Disease (CAD)

Current Pharmacogenomics and Personalized Medicine ◽

10.2174/1875692117666181227112119 ◽

2019 ◽

Vol 16 (3) ◽

pp. 219-229

Author(s):

Renuka Munshi ◽

Falguni Panchal ◽

Ajay Chaurasia ◽

Girish Rajadhyaksha

Keyword(s):

Coronary Artery Disease ◽

Enzyme Activity ◽

Coronary Artery ◽

Gene Polymorphisms ◽

Paraoxonase 1 ◽

Pon1 Gene ◽

Indian Patients ◽

Artery Disease

Download Full-text

Beyond the antioxidant properties: Pomegranate juice polyphenols increase hepatocyte paraoxonase 1 secretion

Atherosclerosis ◽

10.1016/j.atherosclerosis.2009.09.032 ◽

2010 ◽

Vol 208 (1) ◽

pp. 28-29 ◽

Cited By ~ 3

Author(s):

Alejandro Gugliucci

Keyword(s):

Antioxidant Properties ◽

Pomegranate Juice ◽

Paraoxonase 1

Download Full-text

Distribution of paraoxonase-1 gene polymorphisms and enzyme activity in a Peruvian population

Environmental and Molecular Mutagenesis ◽

10.1002/em.20259 ◽

2006 ◽

Vol 47 (9) ◽

pp. 699-706 ◽

Cited By ~ 14

Author(s):

Héctor C. Cataño ◽

Jayme L. Cueva ◽

Anthony M. Cardenas ◽

VÍctor Izaguirre ◽

Amparo I. Zavaleta ◽

...

Keyword(s):

Enzyme Activity ◽

Gene Polymorphisms ◽

Paraoxonase 1

Download Full-text

Additional Common Polymorphisms in thePONGene Cluster Predict PON1 Activity but Not Vascular Disease

Journal of Lipids ◽

10.1155/2012/476316 ◽

2012 ◽

Vol 2012 ◽

pp. 1-11 ◽

Cited By ~ 19

Author(s):

Daniel S. Kim ◽

Amber A. Burt ◽

Jane E. Ranchalis ◽

Rebecca J. Richter ◽

Julieann K. Marshall ◽

...

Keyword(s):

Genetic Variants ◽

Carotid Artery Disease ◽

Paraoxonase 1 ◽

Pon1 Activity ◽

Nucleotide Polymorphisms ◽

Single Nucleotide ◽

Functional Polymorphisms ◽

Functional Snps ◽

Artery Disease ◽

The Many

Background. Paraoxonase 1 (PON1) enzymatic activity has been consistently predictive of cardiovascular disease, while the genotypes at the four functional polymorphisms atPON1have not. The goal of this study was to identify additional variation at thePONgene cluster that improved prediction of PON1 activity and determine if these variants predict carotid artery disease (CAAD).Methods. We considered 1,328 males in a CAAD cohort. 51 tagging single-nucleotide polymorphisms (tag SNPs) across thePONcluster were evaluated to determine their effects on PON1 activity and CAAD status.Results. Six SNPs (four inPON1and one each inPON2/3) predicted PON1 arylesterase (AREase) activity, in addition to the four previously known functional SNPs. In total, the 10 SNPs explained 30.1% of AREase activity, 5% of which was attributable to the six identified predictive SNPs. We replicate rs854567 prediction of 2.3% of AREase variance, the effects of rs3917510, and aPON3haplotype that includes rs2375005. While AREase activity strongly predicted CAAD, none of the 10 SNPs predicting AREase predicted CAAD.Conclusions. This study identifies new genetic variants that predict additional PON1 AREase activity. Identification of SNPs associated with PON1 activity is required when evaluating the many phenotypes associated with genetic variation near PON1.

Download Full-text