rnase l inhibitor
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Viruses ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 174
Author(s):  
Takuto Nogimori ◽  
Koichi Ogami ◽  
Yuka Oishi ◽  
Ryoya Goda ◽  
Nao Hosoda ◽  
...  

The 2′-5′-oligoadenylate synthetase (OAS)/RNase L system protects hosts against pathogenic viruses through cleavage of the exogenous single-stranded RNA. In this system, an evolutionally conserved RNA quality control factor Dom34 (known as Pelota (Pelo) in higher eukaryotes) forms a surveillance complex with RNase L to recognize and eliminate the exogenous RNA in a manner dependent on translation. Here, we newly identified that ATP-binding cassette sub-family E member 1 (ABCE1), which is also known as RNase L inhibitor (RLI), is involved in the regulation of exogenous RNA decay. ABCE1 directly binds to form a complex with RNase L and accelerates RNase L dimer formation in the absence of 2′-5′ oligoadenylates (2-5A). Depletion of ABCE1 represses 2-5A-induced RNase L activation and stabilizes exogenous RNA to a level comparable to that seen in RNase L depletion. The increased half-life of the RNA by the single depletion of either protein is not significantly affected by the double depletion of both proteins, suggesting that RNase L and ABCE1 act together to eliminate exogenous RNA. Our results indicate that ABCE1 functions as a positive regulator of exogenous RNA decay rather than an inhibitor of RNase L.


2018 ◽  
Vol 38 (6) ◽  
Author(s):  
Peng Zhang ◽  
Xiao-Bing Chen ◽  
Bing-Qian Ding ◽  
Hong-Lin Liu ◽  
Tao He

The ATP binding cassette (ABC) E1 (ABCE1), a member of the ABC family, was originally described as the RNase L inhibitor. Through forming a heterodimer with RNase L, ABCE1 participates in the negative regulation of the 2-5A/RNase L system and thus mediates a wide range of biological functions. Recent evidence has shown the new roles of ABCE1 in tumorigenesis. However, there have been no investigations on the specific effect of ABCE1 on glioma. In the present study, we examined the expression pattern and possible role of ABCE1 in glioma. Our study demonstrated that ABCE1 was up-regulated in glioma tissues and cell lines. Down-regulation of ABCE1 inhibited temozolomide (TMZ) resistance of glioma cells in vitro and in vivo. In addition, we found that the PI3K/Akt/NF-κB pathway was involved in ABCE1-mediated chemoresistance of glioma cells. Taken together, our study suggested ABCE1 as a promising target for glioma chemotherapy.


EMBO Reports ◽  
2010 ◽  
Vol 11 (3) ◽  
pp. 214-219 ◽  
Author(s):  
Sohail Khoshnevis ◽  
Thomas Gross ◽  
Carmen Rotte ◽  
Claudia Baierlein ◽  
Ralf Ficner ◽  
...  

Plant Science ◽  
2004 ◽  
Vol 167 (6) ◽  
pp. 1283-1289 ◽  
Author(s):  
Birgit Otzen Petersen ◽  
Bodil Jørgensen ◽  
Merete Albrechtsen

2004 ◽  
Vol 59 (1) ◽  
Author(s):  
AntonioSergioKimus Braz ◽  
Jean Finnegan ◽  
Peter Waterhouse ◽  
Rog�rio Margis

2003 ◽  
pp. 183-198 ◽  
Author(s):  
Catherine Bisbal ◽  
Tamim Salehzada ◽  
Michelle Silhol ◽  
Camille Martinand ◽  
Florence Le Roy ◽  
...  
Keyword(s):  
Rnase L ◽  

DNA Sequence ◽  
2003 ◽  
Vol 14 (4) ◽  
pp. 295-301 ◽  
Author(s):  
Xi-ling Du ◽  
Dong Wang ◽  
Xiao-yin Qian ◽  
Li-zhi Jiang ◽  
Wei Chun ◽  
...  

2002 ◽  
Vol 277 (15) ◽  
pp. 13354
Author(s):  
Florence Le Roy ◽  
Catherine Bisbal ◽  
Michelle Silhol ◽  
Camille Martinand ◽  
Bernard Lebleu ◽  
...  

2001 ◽  
Vol 276 (51) ◽  
pp. 48473-48482 ◽  
Author(s):  
Florence Le Roy ◽  
Catherine Bisbal ◽  
Michelle Silhol ◽  
Camille Martinand ◽  
Bernard Lebleu ◽  
...  

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